2000
Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization
Mari G, Deter R, Carpenter R, Rahman F, Zimmerman R, Moise K, Dorman K, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel J, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell S. Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization. New England Journal Of Medicine 2000, 342: 9-14. PMID: 10620643, DOI: 10.1056/nejm200001063420102.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood Group IncompatibilityCordocentesisErythroblastosis, FetalErythrocytesFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornIsoantibodiesMiddle Cerebral ArteryPregnancyPregnancy Complications, HematologicProspective StudiesReference ValuesRh IsoimmunizationROC CurveSensitivity and SpecificityUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMaternal red cell alloimmunizationRed cell alloimmunizationMiddle cerebral arterySystolic blood flowCerebral arteryBlood flowSevere anemiaFetal anemiaDoppler ultrasonographyNormal fetusesHemoglobin concentrationFetal middle cerebral arteryPeak velocityFetal hemoglobin concentrationAbsence of hydropsPeak systolic velocityGestational ageModerate anemiaSystolic velocityHemoglobin valuesMild anemiaInvasive techniquesAlloimmunizationAnemiaArtery
1995
Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization
Mari G, Adrignolo A, Abuhamad A, Pirhonen J, Jones D, Ludomirsky A, Copel J. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound In Obstetrics And Gynecology 1995, 5: 400-405. PMID: 7552802, DOI: 10.1046/j.1469-0705.1995.05060400.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, HemolyticBlood Flow VelocityBlood Group AntigensCerebral ArteriesCordocentesisErythroblastosis, FetalFemaleFetal BloodGestational AgeHumansInfant, NewbornObserver VariationPregnancyProspective StudiesRetrospective StudiesRh IsoimmunizationROC CurveTransfusion ReactionUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal anemiaGroup AAnemic fetusesMiddle cerebral artery peak systolic velocity valuesMiddle cerebral artery peak velocityFetal middle cerebral artery peak systolic velocityPeak systolic velocity valuesSystolic velocity valuesPeak velocityNormal mean valueAnemia riskNon-invasive methodGroup B.Prospective fashionFetal hematocritGroup BDoppler ultrasoundGroup CNormal fetusesAnemiaFetusesNormal valuesThe predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization
Moise K, Perkins J, Sosler S, Brown S, Saade G, Carpenter R, Thorp J, Ludomirski A, Wilkins I, Grannum P, Copel J. The predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization. American Journal Of Obstetrics And Gynecology 1995, 172: 1003-1009. PMID: 7892839, DOI: 10.1016/0002-9378(95)90034-9.Peer-Reviewed Original ResearchConceptsRed blood cell alloimmunizationFetal anemiaMarsh scoreReceiver operator characteristic curveCoombs titersRed blood cell antibodiesMaternal antibody titersGroups of fetusesMaternal serum testingCharacteristic curveMaternal serum testsMaternal titersCell antibodiesAntigen statusGestational agePregnant womenAntibody titersSerum testingSerum testFetal hematocritInvasive testingFetal bloodKruskal-Wallis testAnemiaFetal disease
1989
Pulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy
Copel J, Grannum P, Green J, Belanger K, Hobbins J. Pulsed Doppler flow-velocity waveforms in the prediction of fetal hematocrit of the severely isoimmunized pregnancy. American Journal Of Obstetrics And Gynecology 1989, 161: 341-344. PMID: 2504040, DOI: 10.1016/0002-9378(89)90516-4.Peer-Reviewed Original ResearchFetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion
Copel J, Grannum P, Green J, Belanger K, Hanna N, Jaffe C, Hobbins J, Kleinman C. Fetal cardiac output in the isoimmunized pregnancy: A pulsed Doppler-echocardiographic study of patients undergoing intravascular intrauterine transfusion. American Journal Of Obstetrics And Gynecology 1989, 161: 361-365. PMID: 2504042, DOI: 10.1016/0002-9378(89)90520-6.Peer-Reviewed Original ResearchConceptsCardiac outputAnemic fetusesIsoimmunized pregnanciesCombined ventricular outputDoppler echocardiographic studyFetal cardiac outputHigh output stateHigh cardiac outputIntravascular intrauterine transfusionSevere isoimmunizationCardiac indexIntrauterine transfusionIntravascular transfusionWeeks' gestationVentricular outputDoppler assessmentAge-specific normsControl fetusesHydrops fetalisControl groupMechanisms of developmentFetusesUnaffected fetusesTransfusionPregnancy
1988
Diagnostic fetal umbilical blood sampling in the management of isoimmunization
Reece E, Copel J, Scioscia A, Grannum P, DeGennaro N, Hobbins J. Diagnostic fetal umbilical blood sampling in the management of isoimmunization. American Journal Of Obstetrics And Gynecology 1988, 159: 1057-1062. PMID: 3142263, DOI: 10.1016/0002-9378(88)90412-7.Peer-Reviewed Original ResearchConceptsAntigen-positive fetusesFetal hemolytic diseaseFetal umbilical bloodManagement of isoimmunizationEarlier gestational ageMultiple invasive proceduresIsoimmunized pregnanciesFetal anemiaAntigen statusGestational ageUmbilical bloodHemolytic diseaseFetal bloodInvasive proceduresCurrent managementFetusesPreliminary reportPregnancyIsoimmunizationDiseaseManagement protocolDiagnosisBloodLittle riskTreatmentPrevention of Rh isoimmunization and treatment of the compromised fetus.
Grannum P, Copel J. Prevention of Rh isoimmunization and treatment of the compromised fetus. Seminars In Perinatology 1988, 12: 324-35. PMID: 3146812.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBlood Transfusion, IntrauterineErythroblastosis, FetalFemaleFetal DeathHumansHydrops FetalisInfant, NewbornPregnancyRh IsoimmunizationConceptsFetal liver functionIntrauterine intravascular transfusionReversal of hydropsCorrection of anemiaWeeks of gestationSevere erythroblastosis fetalisNeonatal exchange transfusionProblems of prematurityNeonatal morbidityErythroblastosis fetalisIntravascular transfusionRh isoimmunizationExchange transfusionLiver functionFetal vasculatureIntravascular treatmentSevere diseaseTreatment teamPrompt correctionCentral veinTreatment centersTransfusionDifficult procedureTreatmentIsoimmunizationPulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis
Copel J, Grannum P, Belanger K, Green J, Hobbins J. Pulsed Doppler flow-velocity waveforms before and after intrauterine intravascular transfusion for severe erythroblastosis fetalis. American Journal Of Obstetrics And Gynecology 1988, 158: 768-774. PMID: 2966585, DOI: 10.1016/0002-9378(88)90070-1.Peer-Reviewed Original ResearchConceptsLate transfusionDoppler flow velocity waveformsIntrauterine intravascular transfusionFlow velocity waveformsSevere erythroblastosis fetalisFirst transfusionIntrauterine transfusionSubsequent transfusionsErythroblastosis fetalisIntravascular transfusionIsoimmunized pregnanciesDoppler studiesMaternal circulationDoppler ultrasoundTransfusionNormal fetusesHematocrit changesLack of changeHematocritDoppler parametersFetusesRapid volumeHydropsPregnancyFetalisThe reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia
Grannum P, Copel J, Moya F, Scioscia A, Robert J, Winn H, Coster B, Burdine C, Hobbins J. The reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia. American Journal Of Obstetrics And Gynecology 1988, 158: 914-919. PMID: 3284364, DOI: 10.1016/0002-9378(88)90094-4.Peer-Reviewed Original ResearchConceptsGm/dlIntrauterine intravascular transfusionIntravascular transfusionHematocrit levelsSurvival rateSevere respiratory distress syndromeReversal of hydropsOverall survival rateRespiratory distress syndromeTime of referralIntravascular intrauterine transfusionSevere erythroblastosis fetalisTotal proteinIntrauterine transfusionNeonatal morbidityErythroblastosis fetalisHydropic fetusesDistress syndromeFetal anemiaExchange transfusionNeonatal deathIntraperitoneal transfusionSevere erythroblastosisNewborn periodIntravascular treatment
1986
In Utero Exchange Transfusion by Direct Intravascular Injection in Severe Erythroblastosis Fetalis
Grannum P, Copel J, Plaxe S, Scioscia A, Hobbins J. In Utero Exchange Transfusion by Direct Intravascular Injection in Severe Erythroblastosis Fetalis. New England Journal Of Medicine 1986, 314: 1431-1434. PMID: 3702951, DOI: 10.1056/nejm198605293142207.Peer-Reviewed Original Research