1995
Successful in utero therapy of fetal heart block
Copel J, Buyon J, Kleinman C. Successful in utero therapy of fetal heart block. American Journal Of Obstetrics And Gynecology 1995, 173: 1384-1390. PMID: 7503173, DOI: 10.1016/0002-9378(95)90621-5.Peer-Reviewed Original ResearchConceptsComplete heart blockFetal heart blockHeart blockAntibody levelsCongenital complete heart blockHeart block patientsMaternal antibody levelsPositive antibody screenSimilar antibody levelsSecond-degree blockDegree of blockCardiac conduction systemFetal cardiac conduction systemConcurrent myocarditisGlucocorticoid therapyMaternal autoantibodiesBlock patientsMaternal antibodiesAntibody screenUtero therapyCord samplesCardiac contractilityRapid resolutionB antibodiesCardiac conduction
1988
The reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia
Grannum P, Copel J, Moya F, Scioscia A, Robert J, Winn H, Coster B, Burdine C, Hobbins J. The reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia. American Journal Of Obstetrics And Gynecology 1988, 158: 914-919. PMID: 3284364, DOI: 10.1016/0002-9378(88)90094-4.Peer-Reviewed Original ResearchConceptsGm/dlIntrauterine intravascular transfusionIntravascular transfusionHematocrit levelsSurvival rateSevere respiratory distress syndromeReversal of hydropsOverall survival rateRespiratory distress syndromeTime of referralIntravascular intrauterine transfusionSevere erythroblastosis fetalisTotal proteinIntrauterine transfusionNeonatal morbidityErythroblastosis fetalisHydropic fetusesDistress syndromeFetal anemiaExchange transfusionNeonatal deathIntraperitoneal transfusionSevere erythroblastosisNewborn periodIntravascular treatment
1985
Fetal atrioventricular valve insufficiency associated with nonimmune hydrops: a two-dimensional echocardiographic and pulsed Doppler ultrasound study.
Silverman N, Kleinman C, Rudolph A, Copel J, Weinstein E, Enderlein M, Golbus M. Fetal atrioventricular valve insufficiency associated with nonimmune hydrops: a two-dimensional echocardiographic and pulsed Doppler ultrasound study. Circulation 1985, 72: 825-832. PMID: 3896564, DOI: 10.1161/01.cir.72.4.825.Peer-Reviewed Original ResearchConceptsAtrioventricular valve insufficiencyStructural heart diseaseNonimmune hydropsValve insufficiencyHeart diseaseLow colloid oncotic pressureFetal cardiac failureAtrioventricular valve regurgitationEarly neonatal periodColloid oncotic pressureCardiac ultrasound examinationDoppler ultrasound studiesM-mode echocardiographyEarly postnatal periodVenous hypertensionHydropic fetusesValve regurgitationCardiac failureSupraventricular tachyarrhythmiasNeonatal periodPoor prognosisEleven fetusesMode echocardiographyUltrasound examinationDoppler ultrasoundIn utero diagnosis and treatment of fetal supraventricular tachycardia.
Kleinman C, Copel J, Weinstein E, Santulli T, Hobbins J. In utero diagnosis and treatment of fetal supraventricular tachycardia. Seminars In Perinatology 1985, 9: 113-29. PMID: 4035386.Peer-Reviewed Original ResearchTreatment of fetal supraventricular tachyarrhythmias
Kleinman C, Copel J, Weinstein E, Santulli T, Hobbins J. Treatment of fetal supraventricular tachyarrhythmias. Journal Of Clinical Ultrasound 1985, 13: 265-273. PMID: 3923049, DOI: 10.1002/jcu.1870130406.Peer-Reviewed Original ResearchConceptsNormal sinus rhythmSupraventricular tachyarrhythmiasSinus rhythmAtrial flutterFetal supraventricular tachyarrhythmiaTime of diagnosisYale-New Haven Medical CenterSevere fetal hydropsAntiarrhythmic therapyElectrical cardioversionMaternal administrationDoppler echocardiographyAtrial fibrillationFetal hydropsAntiarrhythmic agentsElectrophysiologic mechanismsSupraventricular tachycardiaMedical CenterSuccessful therapyCardiac rhythmM-modeFetusesTreatment programTachyarrhythmiasFibrillation