2022
Impact of prenatally diagnosed congenital heart defects on outcomes and management
Wong J, Kohari K, Bahtiyar MO, Copel J. Impact of prenatally diagnosed congenital heart defects on outcomes and management. Journal Of Clinical Ultrasound 2022, 50: 646-654. PMID: 35543387, DOI: 10.1002/jcu.23219.Peer-Reviewed Original ResearchConceptsCongenital heart defectsComplex congenital heart defectEarly fetal echocardiographyImproved survival ratesPrenatal detection rateGood psychosocial supportFetal echocardiogramFetal echocardiographyPatient educationCardiology specialistsHigh riskHeart defectsSurvival rateCongenital heartPsychosocial supportEarly detectionPrenatal identificationPrenatal detectionDelivery planningDetection rateUltrasound technologyImportant contributorEchocardiogramEchocardiographyNeonates
2013
ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart
International Society of Ultrasound in Obstetrics and Gynecology, Carvalho J, Allan L, Chaoui R, Copel J, DeVore G, Hecher K, Lee W, Munoz H, Paladini D, Tutschek B, Yagel S. ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart. Ultrasound In Obstetrics And Gynecology 2013, 41: 348-359. PMID: 23460196, DOI: 10.1002/uog.12403.Commentaries, Editorials and Letters
2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester
2004
Indications for Fetal Echocardiography
Small M, Copel J. Indications for Fetal Echocardiography. Pediatric Cardiology 2004, 25: 210-222. PMID: 15360114, DOI: 10.1007/s00246-003-0587-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2000
The clinical significance of the irregular fetal heart rhythm
Copel J, Liang R, Demasio K, Ozeren S, Kleinman C. The clinical significance of the irregular fetal heart rhythm. American Journal Of Obstetrics And Gynecology 2000, 182: 813-819. PMID: 10764457, DOI: 10.1016/s0002-9378(00)70330-9.Peer-Reviewed Original ResearchConceptsFetal heart rhythmSignificant arrhythmiasHeart rhythmFetal echocardiographyStructural heart diseaseRoutine prenatal careRetrospective reviewFetal echocardiogramPrenatal careHeart diseaseFetal arrhythmiasClinical significanceClinical practiceArrhythmiasAppropriate managementFetusesIrregular rhythmNormal rhythmDifferent fetusesEchocardiographyRhythmImportant proportionLittle informationEchocardiogramNeonates
1995
Successful in utero therapy of fetal heart block
Copel J, Buyon J, Kleinman C. Successful in utero therapy of fetal heart block. American Journal Of Obstetrics And Gynecology 1995, 173: 1384-1390. PMID: 7503173, DOI: 10.1016/0002-9378(95)90621-5.Peer-Reviewed Original ResearchConceptsComplete heart blockFetal heart blockHeart blockAntibody levelsCongenital complete heart blockHeart block patientsMaternal antibody levelsPositive antibody screenSimilar antibody levelsSecond-degree blockDegree of blockCardiac conduction systemFetal cardiac conduction systemConcurrent myocarditisGlucocorticoid therapyMaternal autoantibodiesBlock patientsMaternal antibodiesAntibody screenUtero therapyCord samplesCardiac contractilityRapid resolutionB antibodiesCardiac conductionIn Utero identification and therapy of congenital heart block
Buyon J, Waltuck J, Kleinman C, Copel J. In Utero identification and therapy of congenital heart block. Lupus 1995, 4: 116-121. PMID: 7795614, DOI: 10.1177/096120339500400207.Peer-Reviewed Original ResearchMeSH KeywordsDexamethasoneEchocardiographyFemaleHeart BlockHumansPrednisonePregnancyPrenatal DiagnosisConceptsCongenital heart blockWeeks of gestationHeart blockFluorinated steroidsDegree blockEarly third trimesterSecond-degree blockThird-degree blockDegree of blockDisease activityChart reviewPericardial effusionPrimary physicianThird trimesterSinus rhythmUtero identificationGestational periodPrenatal therapyFetal vulnerabilityPregnancyTiming of identificationTherapyMid secondWeeksPrednisone
1994
Management outcome and follow-up of fetal tachycardia
van Engelen A, Weijtens O, Brenner J, Kleinman C, Copel J, Stoutenbeek P, Meijboom E. Management outcome and follow-up of fetal tachycardia. Journal Of The American College Of Cardiology 1994, 24: 1371-1375. PMID: 7930263, DOI: 10.1016/0735-1097(94)90122-8.Peer-Reviewed Original ResearchConceptsFetal tachycardiaMajority of patientsPharmacologic therapyFetal hydropsAtrial flutterSupraventricular tachycardiaVentricular tachycardiaPresence of hydropsSeries of patientsLife-threatening conditionSerious adverse effectsMonths of ageMaternal therapyProlonged therapyPostpartum managementRhythm controlAntiarrhythmic agentsMedian numberDrug treatmentTachycardiaM-modePatientsOptimal managementTherapyEmergency deliveryAntenatal diagnosis of coarctation of the aorta: A multicenter experience
Hornberger L, Sahn D, Kleinman C, Copel J, Silverman N. Antenatal diagnosis of coarctation of the aorta: A multicenter experience. Journal Of The American College Of Cardiology 1994, 23: 417-423. PMID: 8294696, DOI: 10.1016/0735-1097(94)90429-4.Peer-Reviewed Original ResearchConceptsTransverse archGestational ageSerial studiesDistal archAortic archDouble outlet right ventricleMembranous ventricular septal defectPrenatal studiesAssociated cardiac lesionsDiagnosis of coarctationDistal arch hypoplasiaDistal aortic archVentricular septal defectUnbalanced atrioventricular canalAbnormal aortic valvePresence of coarctationIsthmus hypoplasiaNoncardiac lesionsPrenatal echocardiogramEchocardiographic findingsArch hypoplasiaMulticenter experienceReversal of flowCardiac lesionsVentricle anatomy
1991
Congenital Heart Disease and Fetal Thoracoabdominal Anomalies: Associations in Utero and the Importance of Cytogenetic Analysis
Fogel M, Copel J, Cullen M, Hobbins J, Kleinman C. Congenital Heart Disease and Fetal Thoracoabdominal Anomalies: Associations in Utero and the Importance of Cytogenetic Analysis. American Journal Of Perinatology 1991, 8: 411-416. PMID: 1839950, DOI: 10.1055/s-2007-999427.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePosterior diaphragmatic herniaDuodenal atresiaHeart diseaseExtracardiac malformationsDiaphragmatic herniaFetal echocardiographyNormal cardiac structureFetal echocardiogramMost fetusesPrenatal evaluationAbnormal karyotypeCardiac structureCytogenetic abnormalitiesFetusesAtresiaOmphaloceleNormal karyotypeAbnormalitiesDiseaseEchocardiographyGastroschisisHerniaPrenatal diagnosisMalformationsCardiac growth in fetuses of diabetic mothers with good metabolic control
Weber H, Copel J, Reece E, Green J, Kleinman C. Cardiac growth in fetuses of diabetic mothers with good metabolic control. The Journal Of Pediatrics 1991, 118: 103-107. PMID: 1986073, DOI: 10.1016/s0022-3476(05)81858-x.Peer-Reviewed Original ResearchConceptsGood metabolic controlVentricular diastolic dimensionDiabetic mothersDiastolic dimensionVentricular free wallFree wall ratioMetabolic controlNormal fetusesCardiac growthFetal weightGestational periodCardiac hypertrophyFree wallLeft ventricular diastolic dimensionRight ventricular diastolic dimensionRight ventricular free wallM-mode echocardiographic measurementsSimilar gestational ageStrict metabolic controlDaily glucose profilesM-mode measurementsGestational ageEchocardiographic measurementsInterventricular septumGlucose profilesTricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome
Hornberger L, Sahn D, Kleinman C, Copel J, Reed K. Tricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome. Journal Of The American College Of Cardiology 1991, 17: 167-173. PMID: 1987222, DOI: 10.1016/0735-1097(91)90722-l.Peer-Reviewed Original ResearchConceptsTricuspid valve diseasePulmonary atresiaPulmonary stenosisEbstein's anomalyClinical courseValve diseaseUnguarded tricuspid valve orificeSevere congestive heart failureAssociated cardiac lesionsBenign neonatal courseComplex heart lesionsPulmonary outflow obstructionRight atrial dilationRight-sided cardiomegalySignificant tricuspid insufficiencySignificant tricuspid regurgitationCongestive heart failurePulmonary artery flowTricuspid valve dysplasiaTricuspid valve orificeTricuspid tissueNeonatal courseOutflow obstructionTricuspid insufficiencyTricuspid regurgitation
1988
The frequency of aneuploidy in prenatally diagnosed congenital heart disease: An indication for fetal karyotyping
Copel J, Cullen M, Green J, Mahoney M, Hobbins J, Kleinman C. The frequency of aneuploidy in prenatally diagnosed congenital heart disease: An indication for fetal karyotyping. American Journal Of Obstetrics And Gynecology 1988, 158: 409-413. PMID: 3341415, DOI: 10.1016/0002-9378(88)90166-4.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyEchocardiographyFemaleFetal DiseasesHeart Defects, CongenitalHumansKaryotypingPregnancyPrenatal DiagnosisRisk FactorsConceptsCongenital heart diseaseHeart diseaseFetal heart diseaseFrequency of aneuploidyNeonatal careCardiac anomaliesFetal echocardiogramPediatric literatureFetal karyotypingParental counselingFetal bloodNonviable fetusClinic dataCase identificationChromosomal abnormalitiesFetusesDiseaseAbnormal chromosomesChromosome analysisEchocardiogramInfantsUteroWorkupAbnormalitiesAmniocentesisDevelopment of a benign intrapericardial tumor between 20 and 40 weeks of gestation
Weber H, Kleinman C, Hellenbrand W, Kopf G, Copel J. Development of a benign intrapericardial tumor between 20 and 40 weeks of gestation. Pediatric Cardiology 1988, 9: 153-156. PMID: 3186538, DOI: 10.1007/bf02080556.Peer-Reviewed Case Reports and Technical Notes
1987
Combined echocardiographic and Doppler assessment of fetal congenital atrioventricular block
KLEINMAN C, COPEL J, HOBBINS J. Combined echocardiographic and Doppler assessment of fetal congenital atrioventricular block. BJOG An International Journal Of Obstetrics & Gynaecology 1987, 94: 967-974. PMID: 3689729, DOI: 10.1111/j.1471-0528.1987.tb02271.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultEchocardiographyFemaleFetal DiseasesFetal MonitoringHeart BlockHeart Rate, FetalHumansInfant, NewbornPregnancyConceptsHeart blockFetal echocardiographyThird-degree heart blockElective caesarean deliveryFetal heart rate monitoringDegree heart blockCongenital atrioventricular blockAtrial activityCaesarean deliveryCaesarean sectionCephalopelvic disproportionFetal bradycardiaAtrioventricular blockDoppler assessmentLate decelerationsAtrial rateHeart rate monitoringVagal toneHeart rate monitorEchocardiographyVariable degreesRate monitoringRate monitorBradycardiaPatientsFetal echocardiographic screening for congenital heart disease: The importance of the four-chamber view
Copel J, Pilu G, Green J, Hobbins J, Kleinman C. Fetal echocardiographic screening for congenital heart disease: The importance of the four-chamber view. American Journal Of Obstetrics And Gynecology 1987, 157: 648-655. PMID: 3631166, DOI: 10.1016/s0002-9378(87)80022-4.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseFour-chamber viewHeart diseasePredictive valueRoutine obstetric ultrasound examinationFetal echocardiographic screeningObstetric ultrasound examinationNegative predictive valuePositive predictive valueObstetrical sonographersEchocardiographic screeningUltrasound examinationDiseaseUseful screenAbnormal heartFetusesHeartScreening methodPregnancyAbnormalities
1986
Congenital heart disease and extracardiac anomalies: Associations and indications for fetal echocardiography
Copel J, Pilu G, Kleinman C. Congenital heart disease and extracardiac anomalies: Associations and indications for fetal echocardiography. American Journal Of Obstetrics And Gynecology 1986, 154: 1121-1132. PMID: 2939723, DOI: 10.1016/0002-9378(86)90773-8.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal MusclesAbnormalities, Drug-InducedAbnormalities, MultipleCentral Nervous SystemChromosome AberrationsChromosome DisordersCongenital AbnormalitiesDigestive System AbnormalitiesEchocardiographyFemaleFetal HeartHeart Defects, CongenitalHumansInfant, NewbornPhenylketonuriasPregnancyPregnancy ComplicationsPregnancy in DiabeticsPrenatal DiagnosisRespiratory System AbnormalitiesUrogenital AbnormalitiesConceptsCongenital heart diseaseHeart diseaseExtracardiac anomaliesFetal echocardiographyCardiac evaluationMaternal diabetesNeonatal managementDiaphragmatic herniaDuodenal atresiaPediatric literatureRenal dysplasiaCorpus callosumDifferential diagnosisEsophageal atresiaMeckel-Gruber syndromeReported associationsEchocardiographyPrenatal identificationSystemic defectsDiseaseAtresiaCoexistent defectsAssociationIndicationsDiabetesThe impact of fetal echocardiography on perinatal outcome
Copel J, Kleinman C. The impact of fetal echocardiography on perinatal outcome. Ultrasound In Medicine & Biology 1986, 12: 327-335. PMID: 3716006, DOI: 10.1016/0301-5629(86)90342-x.Peer-Reviewed Original ResearchMeSH KeywordsArrhythmias, CardiacDiseases in TwinsEchocardiographyFemaleHeart Defects, CongenitalHumansPregnancyPrenatal DiagnosisConceptsCongenital heart diseaseExtracardiac anomaliesFetal echocardiographyStructural cardiac diseaseFour-chamber viewPerinatal outcomesNonimmune hydropsFetal echocardiogramHeart diseaseAbdominal circumferenceRhythm abnormalitiesCardiac diseaseHigh incidencePrenatal evaluationCardiac structureOne-year periodFetusesEchocardiographyAbnormalitiesDiseaseFamily membersLarge groupGravidaeEchocardiogramHydrops
1985
Fetal atrioventricular valve insufficiency associated with nonimmune hydrops: a two-dimensional echocardiographic and pulsed Doppler ultrasound study.
Silverman N, Kleinman C, Rudolph A, Copel J, Weinstein E, Enderlein M, Golbus M. Fetal atrioventricular valve insufficiency associated with nonimmune hydrops: a two-dimensional echocardiographic and pulsed Doppler ultrasound study. Circulation 1985, 72: 825-832. PMID: 3896564, DOI: 10.1161/01.cir.72.4.825.Peer-Reviewed Original ResearchConceptsAtrioventricular valve insufficiencyStructural heart diseaseNonimmune hydropsValve insufficiencyHeart diseaseLow colloid oncotic pressureFetal cardiac failureAtrioventricular valve regurgitationEarly neonatal periodColloid oncotic pressureCardiac ultrasound examinationDoppler ultrasound studiesM-mode echocardiographyEarly postnatal periodVenous hypertensionHydropic fetusesValve regurgitationCardiac failureSupraventricular tachyarrhythmiasNeonatal periodPoor prognosisEleven fetusesMode echocardiographyUltrasound examinationDoppler ultrasoundIn utero diagnosis and treatment of fetal supraventricular tachycardia.
Kleinman C, Copel J, Weinstein E, Santulli T, Hobbins J. In utero diagnosis and treatment of fetal supraventricular tachycardia. Seminars In Perinatology 1985, 9: 113-29. PMID: 4035386.Peer-Reviewed Original Research