2022
NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone
Sunderji S, Peyvandi S, Jaeggi E, Szwast A, Ryan G, Tessier F, Siddiqui S, Cuneo B, Sheth S, Treadwell M, Frommelt M, Turan S, Copel J, Emery S, Rand L, Moon-Grady AJ, Network F. NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 9263-9270. PMID: 35014577, DOI: 10.1080/14767058.2022.2025536.Peer-Reviewed Original ResearchConceptsPositive pregnanciesPrimary outcomePregnancy complicationsPregnancy outcomesPremature deliverySecondary outcomesNorth American Fetal Therapy Network (NAFTNet) centersRo/SSA-positive pregnanciesRetrospective multi-center cohort studyAnti-Ro/SSAMulti-center cohort studyFetal heart blockOverall pregnancy complicationsBetter pregnancy outcomesPoor pregnancy outcomesUse of dexamethasoneTerms of efficacyHigh rateFetal dyadsMaternal comorbiditiesAntibody positivityExpectant managementMaternal diseaseNeonatal morbidityPreterm delivery
2020
Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers
Tollenaar L, Slaghekke F, Lewi L, Ville Y, Lanna M, Weingertner A, Ryan G, Arévalo S, Khalil A, Brock C, Klaritsch P, Hecher K, Gardener G, Bevilacqua E, Kostyukov K, Bahtiyar M, Kilby M, Tiblad E, Oepkes D, Lopriore E, Middeldorp J, Haak M, Klumper F, Akkermans J, Delagrange H, Pandya V, Faiola S, Favre R, Hobson S, Rodo C, Thilaganathan B, Papanna R, Greimel P, de Sousa M, Carlin A, Gladkova K, Copel J. Treatment and outcome of 370 cases with spontaneous or post‐laser twin anemia–polycythemia sequence managed in 17 fetal therapy centers. Ultrasound In Obstetrics And Gynecology 2020, 56: 378-387. PMID: 32291846, PMCID: PMC7497010, DOI: 10.1002/uog.22042.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequenceFetal therapy centersMonochorionic twin pregnanciesPost-laser twin anemia-polycythemia sequenceExpectant management groupSevere neonatal morbidityIntrauterine transfusionExpectant managementPerinatal mortalitySelective feticideTwin pregnanciesLaser surgeryNeonatal morbidityDelivery groupIUT groupDiagnosis of TAPSMiddle cerebral artery peak systolic velocityFetal middle cerebral artery peak systolic velocityBirth intervalLaser surgery groupProlongation of pregnancyTherapy CenterPeak systolic velocityLarge international cohortMedian diagnosis
2019
Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester
1999
Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus
Saleeb S, Copel J, Friedman D, Buyon J. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus. Arthritis & Rheumatism 1999, 42: 2335-2345. PMID: 10555029, DOI: 10.1002/1529-0131(199911)42:11<2335::aid-anr12>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsCongenital heart blockSecond-degree blockThird-degree blockGroup B fetusesGroup BGroup AHeart blockAge 4 yearsNeonatal lupusPericardial effusionPleural effusionResearch RegistryFluorinated steroidsAutoantibody-associated congenital heart blockAnti-SSB/La antibodiesAnti-SSA/RoFluorinated glucocorticoidsNatural historyInitial echocardiographic evaluationDuration of pregnancyIntrauterine growth restrictionFirst-degree blockNumber of deathsComparison of treatmentsSteroid therapyThrombomodulin: A New Marker for Placental Abruption
Magriples U, Chan D, Bruzek D, Copel J, Hsu C. Thrombomodulin: A New Marker for Placental Abruption. Thrombosis And Haemostasis 1999, 81: 32-34. PMID: 9974370, DOI: 10.1055/s-0037-1614413.Peer-Reviewed Original ResearchMeSH KeywordsAbruptio PlacentaeBiomarkersCohort StudiesEndothelium, VascularFemaleHumansPregnancyProspective StudiesThrombomodulinConceptsPlacental abruptionAcute placental abruptionAbnormal coagulation profileProspective cohort studyEndothelial cell damageCohort studyCoagulation profilePathologic evidencePregnant womenKleihauer-BetkeAbruptionGroup 2Group 1Placental syncytiotrophoblastClinical diagnosisThrombomodulinCell damageSpecific markersNew markersPatientsMarkersDeliverySyncytiotrophoblastDiagnosisWomen
1998
Elevated amniotic fluid nitric oxide metabolites and interleukin-6 in intra-amniotic infection.
Hsu C, Meaddough E, Hong S, Aversa K, Lu L, Copel J. Elevated amniotic fluid nitric oxide metabolites and interleukin-6 in intra-amniotic infection. Reproductive Sciences 1998, 5: 21-4. PMID: 9501294, DOI: 10.1016/s1071-5576(97)00099-3.Peer-Reviewed Original ResearchConceptsAmniotic fluid nitric oxide metabolitesIntra-amniotic infectionNitric oxide metabolitesLeukocyte esterase activityIL-6Oxide metabolitesLeukocyte countInterleukin-6Glucose levelsRank correlation testAmniotic fluid creatinine levelsAmniotic fluid glucose levelAmniotic fluid IL-6Positive amniotic fluid cultureGram stainIL-6 levelsInterleukin-6 concentrationsIL-6 concentrationsAmniotic fluid leukocyte countsUseful clinical markerMann-Whitney U testEnzyme-linked immunosorbentAmniotic fluid cultureCreatinine levelsGestational age