2023
Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally
Bobba P, Weber C, Malhotra A, Bahtiyar M, Copel J, Taylor S, Ment L, Payabvash S. Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally. Scientific Reports 2023, 13: 21514. PMID: 38057452, PMCID: PMC10700578, DOI: 10.1038/s41598-023-48963-z.Peer-Reviewed Original Research
2022
NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone
Sunderji S, Peyvandi S, Jaeggi E, Szwast A, Ryan G, Tessier F, Siddiqui S, Cuneo B, Sheth S, Treadwell M, Frommelt M, Turan S, Copel J, Emery S, Rand L, Moon-Grady AJ, Network F. NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 9263-9270. PMID: 35014577, DOI: 10.1080/14767058.2022.2025536.Peer-Reviewed Original ResearchConceptsPositive pregnanciesPrimary outcomePregnancy complicationsPregnancy outcomesPremature deliverySecondary outcomesNorth American Fetal Therapy Network (NAFTNet) centersRo/SSA-positive pregnanciesRetrospective multi-center cohort studyAnti-Ro/SSAMulti-center cohort studyFetal heart blockOverall pregnancy complicationsBetter pregnancy outcomesPoor pregnancy outcomesUse of dexamethasoneTerms of efficacyHigh rateFetal dyadsMaternal comorbiditiesAntibody positivityExpectant managementMaternal diseaseNeonatal morbidityPreterm delivery
2019
Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFetal HeartHumansLungLung DiseasesPregnancyRetrospective StudiesSensitivity and SpecificityUltrasonography, PrenatalYoung AdultConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2014
Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth
Zuckerwise L, Nayeri U, Abdel-Razeq S, Copel J, Bahtiyar M. Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth. Journal Of Perinatology 2014, 35: 387-389. PMID: 25521562, DOI: 10.1038/jp.2014.223.Peer-Reviewed Original ResearchConceptsDoppler flow velocity waveformsFlow velocity waveformsDiscordant growthVelocity waveformsTwin gestationsSmall fetusesAbnormal umbilical artery Doppler flow velocity waveformsUmbilical artery Doppler flow velocity waveformsMonochorionic diamniotic twin gestationsMonochorionic diamniotic twin pregnanciesNeonatal intensive care unitDiamniotic twin gestationsMCDA twin pairsDiamniotic twin pregnanciesEnd-diastolic flowLow Apgar scoreBirth weight discordanceDiscordant fetal growthIntensive care unitTwin transfusion syndromeDoppler velocity waveformsT-testElectronic medical recordsTwin pairsStudent's t-test
2003
Delivery at 34 weeks is more costly than at 35 weeks in pregnancies with premature rupture of membranes
Magriples U, Crichton R, Ehrenkranz R, Copel J. Delivery at 34 weeks is more costly than at 35 weeks in pregnancies with premature rupture of membranes. The Journal Of Maternal-Fetal & Neonatal Medicine 2003, 14: 22-25. PMID: 14563087, DOI: 10.1080/jmf.14.1.22.25.Peer-Reviewed Original ResearchConceptsPremature ruptureIntensive care unit stayPreterm premature ruptureMother-infant pairsUnit stayMaternal demographicsNeonatal morbidityPreterm PROMSingleton gestationsNeonatal interventionsNeonatal lengthRetrospective studyProspective dataRelative riskDelay of deliveryWeeksDirect costsSignificant differencesPatientsSignificant increaseStayInfantsDeliveryCost of deliveryRupture
2000
Color Doppler imaging of placental masses: differential diagnosis and fetal outcome
Prapas N, Liang R, Hunter D, Copel J, Lu L, Pazkash V, Mari G. Color Doppler imaging of placental masses: differential diagnosis and fetal outcome. Ultrasound In Obstetrics And Gynecology 2000, 16: 559-563. PMID: 11169351, DOI: 10.1046/j.1469-0705.2000.00324.x.Peer-Reviewed Original ResearchConceptsCases of chorioangiomaPlacental massPlacental hemorrhagePremature laborDifferential diagnosisRapid tumor growthColor Doppler imagingColor flow mappingPlacental chorioangiomaFetal outcomesPerinatal outcomesNeonatal deathRetrospective studyDoppler examinationBlood flowChorioangiomaColor DopplerDoppler imagingTumor growthHemorrhageHalf year periodFlow mappingOnly caseDiagnosisSuch massesThe clinical significance of the irregular fetal heart rhythm
Copel J, Liang R, Demasio K, Ozeren S, Kleinman C. The clinical significance of the irregular fetal heart rhythm. American Journal Of Obstetrics And Gynecology 2000, 182: 813-819. PMID: 10764457, DOI: 10.1016/s0002-9378(00)70330-9.Peer-Reviewed Original ResearchMeSH KeywordsArrhythmias, CardiacEchocardiographyFemaleHeart Rate, FetalHemodynamicsHumansInfant, NewbornPregnancyRetrospective StudiesUltrasonography, PrenatalConceptsFetal heart rhythmSignificant arrhythmiasHeart rhythmFetal echocardiographyStructural heart diseaseRoutine prenatal careRetrospective reviewFetal echocardiogramPrenatal careHeart diseaseFetal arrhythmiasClinical significanceClinical practiceArrhythmiasAppropriate managementFetusesIrregular rhythmNormal rhythmDifferent fetusesEchocardiographyRhythmImportant proportionLittle informationEchocardiogramNeonates
1999
Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus
Saleeb S, Copel J, Friedman D, Buyon J. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus. Arthritis & Rheumatism 1999, 42: 2335-2345. PMID: 10555029, DOI: 10.1002/1529-0131(199911)42:11<2335::aid-anr12>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsCongenital heart blockSecond-degree blockThird-degree blockGroup B fetusesGroup BGroup AHeart blockAge 4 yearsNeonatal lupusPericardial effusionPleural effusionResearch RegistryFluorinated steroidsAutoantibody-associated congenital heart blockAnti-SSB/La antibodiesAnti-SSA/RoFluorinated glucocorticoidsNatural historyInitial echocardiographic evaluationDuration of pregnancyIntrauterine growth restrictionFirst-degree blockNumber of deathsComparison of treatmentsSteroid therapy
1998
Glycosylated Hemoglobin in Insulin-Dependent Diabetes Mellitus Related to Preeclampsia
Hsu C, Hong S, Nickless N, Copel J. Glycosylated Hemoglobin in Insulin-Dependent Diabetes Mellitus Related to Preeclampsia. American Journal Of Perinatology 1998, 15: 199-202. PMID: 9572378, DOI: 10.1055/s-2007-993926.Peer-Reviewed Original ResearchConceptsIDDM pregnant womenMean HbA1c valuesIncidence of preeclampsiaHbA1c valuesPregnant womenGestational periodExact testInsulin-dependent diabetes mellitusHigher mean HbA1cPathogenesis of preeclampsiaWeeks of gestationFisher's exact testDifferent gestational periodsNormal mean valueIDDM pregnanciesMean HbA1cDiabetes mellitusWeeks' gestationGlycosylated hemoglobinInsulin-DependentRetrospective studyTrophoblastic invasionMedical recordsPreeclampsiaHigh incidence
1996
Strategies for Reducing the Frequency of Preeclampsia in Pregnancies with Insulin-Dependent Diabetes Mellitus
Hsu C, Tan H, Hong S, Nickless N, Copel J. Strategies for Reducing the Frequency of Preeclampsia in Pregnancies with Insulin-Dependent Diabetes Mellitus. American Journal Of Perinatology 1996, 13: 265-268. PMID: 8863944, DOI: 10.1055/s-2007-994340.Peer-Reviewed Original ResearchConceptsFrequency of preeclampsiaIncidence of preeclampsiaGlycemic controlIDDM pregnanciesExact testPregnant insulin-dependent diabeticsYale-New Haven HospitalInsulin-dependent diabeticsOccurrence of preeclampsiaComplete medical recordsFisher's exact testChi-square testInsulin-DependentMedical recordsLower incidencePreeclampsiaGroup 2Group 1PregnancyGroup 3Group 4IncidenceEclampsiaMellitusDiabetics
1995
Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization
Mari G, Adrignolo A, Abuhamad A, Pirhonen J, Jones D, Ludomirsky A, Copel J. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound In Obstetrics And Gynecology 1995, 5: 400-405. PMID: 7552802, DOI: 10.1046/j.1469-0705.1995.05060400.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, HemolyticBlood Flow VelocityBlood Group AntigensCerebral ArteriesCordocentesisErythroblastosis, FetalFemaleFetal BloodGestational AgeHumansInfant, NewbornObserver VariationPregnancyProspective StudiesRetrospective StudiesRh IsoimmunizationROC CurveTransfusion ReactionUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal anemiaGroup AAnemic fetusesMiddle cerebral artery peak systolic velocity valuesMiddle cerebral artery peak velocityFetal middle cerebral artery peak systolic velocityPeak systolic velocity valuesSystolic velocity valuesPeak velocityNormal mean valueAnemia riskNon-invasive methodGroup B.Prospective fashionFetal hematocritGroup BDoppler ultrasoundGroup CNormal fetusesAnemiaFetusesNormal values
1994
Management outcome and follow-up of fetal tachycardia
van Engelen A, Weijtens O, Brenner J, Kleinman C, Copel J, Stoutenbeek P, Meijboom E. Management outcome and follow-up of fetal tachycardia. Journal Of The American College Of Cardiology 1994, 24: 1371-1375. PMID: 7930263, DOI: 10.1016/0735-1097(94)90122-8.Peer-Reviewed Original ResearchConceptsFetal tachycardiaMajority of patientsPharmacologic therapyFetal hydropsAtrial flutterSupraventricular tachycardiaVentricular tachycardiaPresence of hydropsSeries of patientsLife-threatening conditionSerious adverse effectsMonths of ageMaternal therapyProlonged therapyPostpartum managementRhythm controlAntiarrhythmic agentsMedian numberDrug treatmentTachycardiaM-modePatientsOptimal managementTherapyEmergency deliveryAntenatal diagnosis of coarctation of the aorta: A multicenter experience
Hornberger L, Sahn D, Kleinman C, Copel J, Silverman N. Antenatal diagnosis of coarctation of the aorta: A multicenter experience. Journal Of The American College Of Cardiology 1994, 23: 417-423. PMID: 8294696, DOI: 10.1016/0735-1097(94)90429-4.Peer-Reviewed Original ResearchConceptsTransverse archGestational ageSerial studiesDistal archAortic archDouble outlet right ventricleMembranous ventricular septal defectPrenatal studiesAssociated cardiac lesionsDiagnosis of coarctationDistal arch hypoplasiaDistal aortic archVentricular septal defectUnbalanced atrioventricular canalAbnormal aortic valvePresence of coarctationIsthmus hypoplasiaNoncardiac lesionsPrenatal echocardiogramEchocardiographic findingsArch hypoplasiaMulticenter experienceReversal of flowCardiac lesionsVentricle anatomy
1993
Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization.
Saade G, Moise K, Copel J, Belfort M, Carpenter R. Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization. Obstetrics And Gynecology 1993, 82: 987-91. PMID: 8233277.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, HemolyticFetal BloodHumansHydrops FetalisPlatelet CountRetrospective StudiesSeverity of Illness IndexConceptsRed cell alloimmunizationFetal platelet countPlatelet countNonhydropic fetusesBilirubin levelsReticulocyte countMaternal red cell alloimmunizationLow platelet countStudent's t-testFetal plateletsHydropic fetusesIntrauterine transfusionFetal anemiaGestational ageInitial transfusionAnemic fetusesHematopoietic stem cellsFetusesAlloimmunizationThrombocytopeniaTransfusionRegression analysisT-testAnemiaHydropic
1991
The antenatal diagnosis of congenital heart disease using fetal echocardiography: is color flow mapping necessary?
Copel J, Morotti R, Hobbins J, Kleinman C. The antenatal diagnosis of congenital heart disease using fetal echocardiography: is color flow mapping necessary? Obstetrics And Gynecology 1991, 78: 1-8. PMID: 2047049.Peer-Reviewed Original ResearchMeSH KeywordsEchocardiography, DopplerFemaleHeart Defects, CongenitalHumansPregnancyRetrospective StudiesUltrasonography, PrenatalConceptsColor flow mappingTricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome
Hornberger L, Sahn D, Kleinman C, Copel J, Reed K. Tricuspid valve disease with significant tricuspid insufficiency in the fetus: Diagnosis and outcome. Journal Of The American College Of Cardiology 1991, 17: 167-173. PMID: 1987222, DOI: 10.1016/0735-1097(91)90722-l.Peer-Reviewed Original ResearchConceptsTricuspid valve diseasePulmonary atresiaPulmonary stenosisEbstein's anomalyClinical courseValve diseaseUnguarded tricuspid valve orificeSevere congestive heart failureAssociated cardiac lesionsBenign neonatal courseComplex heart lesionsPulmonary outflow obstructionRight atrial dilationRight-sided cardiomegalySignificant tricuspid insufficiencySignificant tricuspid regurgitationCongestive heart failurePulmonary artery flowTricuspid valve dysplasiaTricuspid valve orificeTricuspid tissueNeonatal courseOutflow obstructionTricuspid insufficiencyTricuspid regurgitation
1985
Value of culdocentesis in the diagnosis of ectopic pregnancy.
Romero R, Copel J, Kadar N, Jeanty P, Decherney A, Hobbins J. Value of culdocentesis in the diagnosis of ectopic pregnancy. Obstetrics And Gynecology 1985, 65: 519-22. PMID: 3982726.Peer-Reviewed Original ResearchConceptsEctopic pregnancyPositive culdocentesisTubal ectopic pregnancyEvaluation of patientsTime of surgeryClinician suspicionEctopic gestationPeritoneal signsUnruptured tubeCuldocentesisAuthors' patientsPatientsPregnancyDiagnostic valueHemoperitoneumSuspicionDiagnosisThree-year periodOne-quarterThree-quartersSuch findingsSurgeryGestationWomen