2022
Postpartum cervical length as a predictor of subsequent preterm birth—novel insights on an old enigma
Lauterbach R, Bachar G, Ben-David C, Justman N, Siegler Y, Tzur L, Copel JA, Weiner Z, Beloosesky R, Ginsberg Y. Postpartum cervical length as a predictor of subsequent preterm birth—novel insights on an old enigma. American Journal Of Obstetrics And Gynecology 2022, 228: 461.e1-461.e8. PMID: 36265677, DOI: 10.1016/j.ajog.2022.10.012.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthSubsequent spontaneous preterm birthCervical lengthCervical length measurementPreterm birthPreterm birth groupGestational ageHours postpartumWeeks postpartumTerm groupBirth groupShort cervical lengthSubsequent preterm birthAdverse perinatal outcomesMaternal risk factorsProspective cohort studySingle tertiary centerGroup of patientsPhase 1Perinatal outcomesCohort studyTerm deliveryTertiary centerSubsequent pregnancyPostpartum period
2020
Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP. Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers. Journal Of The American College Of Cardiology 2020, 76: 292-302. PMID: 32674792, PMCID: PMC7394202, DOI: 10.1016/j.jacc.2020.05.045.Peer-Reviewed Original ResearchConceptsCongenital heart blockPrimary outcomeSecondary outcomesEndocardial fibroelastosisHeart blockRecurrence of CHBSSA/Ro-positive mothersAnti-SSA/RoMacrophage Toll-like receptorToll-like receptor antagonistsCutaneous neonatal lupusRo-positive mothersGestational weeks 10Toll-like receptorsFetal cardiac diseaseNeonatal lupusPositive mothersSecondary preventionSkin rashPrevious pregnancyTreat analysisClinical evidenceRecurrence rateReceptor antagonistOptimal approach
2009
Prospective Evaluation of Fetuses With Autoimmune-Associated Congenital Heart Block Followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study
Friedman DM, Kim MY, Copel JA, Llanos C, Davis C, Buyon JP. Prospective Evaluation of Fetuses With Autoimmune-Associated Congenital Heart Block Followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study. The American Journal Of Cardiology 2009, 103: 1102-1106. PMID: 19361597, PMCID: PMC2730772, DOI: 10.1016/j.amjcard.2008.12.027.Peer-Reviewed Original ResearchConceptsThird-degree blockSecond-degree blockCongenital heart blockFirst-degree blockDEX groupHeart blockAutoimmune-Associated Congenital Heart BlockEfficacy of dexamethasoneSteroid side effectsNormal sinus rhythmMedian ventricular ratesCardiac dysfunctionGestational ageVentricular rateNonrandomized studyProspective evaluationSinus rhythmGrowth restrictionPR intervalPacemaker useRare caseTherapeutic benefitSide effectsBirth ageDexamethasone
2008
Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester
2001
Ratio of nuchal thickness to humerus length for Down syndrome detection
Bahado-Singh R, Oz U, Hsu C, Deren O, Copel J, Mahoney M. Ratio of nuchal thickness to humerus length for Down syndrome detection. American Journal Of Obstetrics And Gynecology 2001, 184: 1284-1288. PMID: 11349203, DOI: 10.1067/mob.2001.113878.Peer-Reviewed Original ResearchConceptsDown syndrome riskHigh-risk groupMaternal ageSyndrome riskNuchal thicknessDown syndromeDown syndrome detectionStudy populationIndividual Down's syndrome riskMean gestational ageOverall study populationAge-related riskHumerus lengthSyndrome detectionDown syndrome casesDown's syndrome likelihood ratiosGestational ageProspective dataHealthy groupGross anomaliesNormal fetusesSyndrome casesBiparietal diameterAmniocentesis casesFetal populationCan Risk Factor Assessment Replace Universal Screening for Gonorrhea and Chlamydia in the Third Trimester?
Magriples U, Copel J. Can Risk Factor Assessment Replace Universal Screening for Gonorrhea and Chlamydia in the Third Trimester? American Journal Of Perinatology 2001, 18: 465-468. PMID: 11733863, DOI: 10.1055/s-2001-18790.Peer-Reviewed Original ResearchConceptsThird trimesterPrenatal careInitial negative testNegative initial screenRisk factor screeningThird-trimester testingUrban clinic populationFirst prenatal visitHistory of STDNegative predictive valueAbsence of RFRF screeningPrenatal visitChlamydia screeningGestational agePositive RFStudy criteriaClinic populationClinic settingUniversal screeningLower riskProspective analysisNegative testPredictive valueDrug use
2000
Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization
Mari G, Deter R, Carpenter R, Rahman F, Zimmerman R, Moise K, Dorman K, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel J, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell S. Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization. New England Journal Of Medicine 2000, 342: 9-14. PMID: 10620643, DOI: 10.1056/nejm200001063420102.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood Group IncompatibilityCordocentesisErythroblastosis, FetalErythrocytesFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornIsoantibodiesMiddle Cerebral ArteryPregnancyPregnancy Complications, HematologicProspective StudiesReference ValuesRh IsoimmunizationROC CurveSensitivity and SpecificityUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMaternal red cell alloimmunizationRed cell alloimmunizationMiddle cerebral arterySystolic blood flowCerebral arteryBlood flowSevere anemiaFetal anemiaDoppler ultrasonographyNormal fetusesHemoglobin concentrationFetal middle cerebral arteryPeak velocityFetal hemoglobin concentrationAbsence of hydropsPeak systolic velocityGestational ageModerate anemiaSystolic velocityHemoglobin valuesMild anemiaInvasive techniquesAlloimmunizationAnemiaArtery
1999
Assessment of Doppler velocimetry of the fetal umbilical artery by multigate spectral Doppler scanning and traditional pulsed Doppler ultrasonography plus color flow mapping.
Prapas N, Mari G, Liang R, Copel J. Assessment of Doppler velocimetry of the fetal umbilical artery by multigate spectral Doppler scanning and traditional pulsed Doppler ultrasonography plus color flow mapping. Journal Of Ultrasound In Medicine 1999, 18: 831-835. PMID: 10591448, DOI: 10.7863/jum.1999.18.12.831.Peer-Reviewed Original ResearchGestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk
Bahado‐Singh R, Oz U, Kovanci E, Deren O, Feather M, Hsu C, Copel J, Mahoney M. Gestational age standardized nuchal thickness values for estimating mid‐trimester Down's syndrome risk. The Journal Of Maternal-Fetal Medicine 1999, 8: 37-43. PMID: 10090488, DOI: 10.1002/(sici)1520-6661(199903/04)8:2<37::aid-mfm1>3.0.co;2-p.Peer-Reviewed Original ResearchThrombomodulin: A New Marker for Placental Abruption
Magriples U, Chan D, Bruzek D, Copel J, Hsu C. Thrombomodulin: A New Marker for Placental Abruption. Thrombosis And Haemostasis 1999, 81: 32-34. PMID: 9974370, DOI: 10.1055/s-0037-1614413.Peer-Reviewed Original ResearchMeSH KeywordsAbruptio PlacentaeBiomarkersCohort StudiesEndothelium, VascularFemaleHumansPregnancyProspective StudiesThrombomodulinConceptsPlacental abruptionAcute placental abruptionAbnormal coagulation profileProspective cohort studyEndothelial cell damageCohort studyCoagulation profilePathologic evidencePregnant womenKleihauer-BetkeAbruptionGroup 2Group 1Placental syncytiotrophoblastClinical diagnosisThrombomodulinCell damageSpecific markersNew markersPatientsMarkersDeliverySyncytiotrophoblastDiagnosisWomenA high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome risk
1998
An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers
Bahado-Singh R, Deren O, Oz U, Tan A, Hunter D, Copel J, Mahoney M. An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. American Journal Of Obstetrics And Gynecology 1998, 179: 514-519. PMID: 9731862, DOI: 10.1016/s0002-9378(98)70388-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisCounselingDown SyndromeFemaleHumansLikelihood FunctionsMaternal AgePregnancyProspective StudiesUltrasonography, PrenatalConceptsHyperechoic fetal bowelMaternal ageDown syndromeFetal bowelUltrasonographic parametersScreen-positive rateSignificant independent predictorsAge-related riskDown syndrome riskIndividual oddsLikelihood ratioPositive predictive valueHypoplastic fifth digitDigit hypoplasiaWeeks' gestationIndependent predictorsNormal medianIndividual Down syndrome oddsSingleton fetusesSyndrome riskUltrasonographic markersSerum screeningGenetic amniocentesisHigh riskNuchal thickeningCan Risk Factor Screening Predict Hepatitis C Antibody Reactivity?
Magriples U, Bernstein P, Snyder E, Copel J. Can Risk Factor Screening Predict Hepatitis C Antibody Reactivity? American Journal Of Perinatology 1998, 15: 395-398. PMID: 9722062, DOI: 10.1055/s-2007-993964.Peer-Reviewed Original ResearchConceptsHepatitis C virusPercent of womenRisk factorsEnzyme-linked immunoadsorbent assaySecond-generation testingHistory of hepatitisIntravenous drug useNegative predictive valueHCV exposureRF screeningConsecutive patientsProspective studyC virusLower riskAntibody reactivityPredictive valueDrug useImmunoadsorbent assayWomenPatientsScreeningAssaysPercentHepatitisPrevalenceSubtle ultrasonographic anomalies: Do they improve the Down syndrome detection rate?
Deren O, Mahoney M, Copel J, Bahado-Singh R. Subtle ultrasonographic anomalies: Do they improve the Down syndrome detection rate? American Journal Of Obstetrics And Gynecology 1998, 178: 441-445. PMID: 9539505, DOI: 10.1016/s0002-9378(98)70417-x.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAnthropometryCerebral VentriclesDown SyndromeFemaleFingersHumansIntestinesKidney PelvisPredictive Value of TestsPregnancyPregnancy Trimester, SecondProspective StudiesStatistics as TopicUltrasonography, Doppler, ColorUltrasonography, Doppler, TranscranialUltrasonography, Prenatal
1997
Circulating Thrombomodulin Levels and Clinical Correlates in Pregnant Diabetics
Magriples U, Hsu C, Chan D, Nickless N, Copel J. Circulating Thrombomodulin Levels and Clinical Correlates in Pregnant Diabetics. American Journal Of Perinatology 1997, 14: 605-608. PMID: 9605246, DOI: 10.1055/s-2008-1040762.Peer-Reviewed Original ResearchConceptsDuration of diabetesPregnant diabeticsClinical correlatesGroup 1Prospective cohort studyInsulin-dependent diabetesWeeks of gestationGestational diabetesCohort studyDiabetic pregnanciesSerum creatinineRenal diseaseThrombomodulin levelsEndothelial damageWhite classificationUnderwent determinationTM levelsDiabetesHbA1cDiabeticsThrombomodulinShort-term controlSignificant differencesDurationCorrelates
1996
Risk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results
Bahado-Singh R, Tan A, Deren O, Hunter D, Copel J, Mahoney M. Risk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results. American Journal Of Obstetrics And Gynecology 1996, 175: 824-829. PMID: 8885729, DOI: 10.1016/s0002-9378(96)80006-8.Peer-Reviewed Original ResearchAdrenal artery velocity waveforms in the appropriate and small‐for‐gestational‐age fetus
Mari G, Uerpairojkit B, Abuhamad A, Copel J. Adrenal artery velocity waveforms in the appropriate and small‐for‐gestational‐age fetus. Ultrasound In Obstetrics And Gynecology 1996, 8: 82-86. PMID: 8883308, DOI: 10.1046/j.1469-0705.1996.08020082.x.Peer-Reviewed Original ResearchConceptsGestational age fetusesArtery pulsatility indexFlow velocity waveformsPulsatility indexVelocity waveformsAdrenal arteryFetal heart rate decelerationsHeart rate decelerationsPreterm deliveryCesarean sectionGestational ageDoppler ultrasonographyAdrenal glandBlood flowHigh incidenceNormal fetusesFetusesRate decelerationConfidence intervalsSuccess rateArteryUltrasonographyGestationIncidence
1995
Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results
Bahado-Singh R, Goldstein I, Uerpairojkit B, Copel J, Mahoney M, Baumgarten A. Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results. American Journal Of Obstetrics And Gynecology 1995, 173: 1106-1110. PMID: 7485301, DOI: 10.1016/0002-9378(95)91334-3.Peer-Reviewed Original ResearchConceptsAbnormal triple-screen resultsTriple-screen resultsNuchal thicknessDown syndromeHuman chorionic gonadotropin levelsNuchal thickness measurementChorionic gonadotropin levelsReceiver operator characteristic curveNumber of amniocentesesReceiver operator characteristic plotsRisk thresholdMidtrimester pregnancyGonadotropin levelsWeeks' gestationMaternal ageConsecutive fetusesUnconjugated estriolSerum screeningEuploid fetusesAlpha-fetoproteinSyndromeTrisomy 21Screen resultsRisk estimatesFetusesSingle umbilical artery: Does it matter which artery is missing?
Abuhamad A, Shaffer W, Mari G, Copel J, Hobbins J, Evans A. Single umbilical artery: Does it matter which artery is missing? American Journal Of Obstetrics And Gynecology 1995, 173: 728-732. PMID: 7573234, DOI: 10.1016/0002-9378(95)90331-3.Peer-Reviewed Original ResearchConceptsSingle umbilical arteryGestational age fetusesUmbilical arteryLeft arteryCongenital anomaliesRight arteryIsolated single umbilical arteryComplex fetal anomaliesLeft umbilical arteryComplex congenital anomaliesProspective studyIsolated findingFetal anomaliesArteryCytogenetic abnormalitiesComplex anomaliesFetusesPregnancyPrevious reportsAbsenceAbnormalitiesIncidenceSonogramsDiagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization
Mari G, Adrignolo A, Abuhamad A, Pirhonen J, Jones D, Ludomirsky A, Copel J. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound In Obstetrics And Gynecology 1995, 5: 400-405. PMID: 7552802, DOI: 10.1046/j.1469-0705.1995.05060400.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, HemolyticBlood Flow VelocityBlood Group AntigensCerebral ArteriesCordocentesisErythroblastosis, FetalFemaleFetal BloodGestational AgeHumansInfant, NewbornObserver VariationPregnancyProspective StudiesRetrospective StudiesRh IsoimmunizationROC CurveTransfusion ReactionUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal anemiaGroup AAnemic fetusesMiddle cerebral artery peak systolic velocity valuesMiddle cerebral artery peak velocityFetal middle cerebral artery peak systolic velocityPeak systolic velocity valuesSystolic velocity valuesPeak velocityNormal mean valueAnemia riskNon-invasive methodGroup B.Prospective fashionFetal hematocritGroup BDoppler ultrasoundGroup CNormal fetusesAnemiaFetusesNormal values