1996
Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening
Rotmensch S, Liberati M, Kardana A, Copel J, Ben-Rafael Z, Cole L. Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening. American Journal Of Obstetrics And Gynecology 1996, 174: 609-611. PMID: 8623792, DOI: 10.1016/s0002-9378(96)70435-0.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinDown syndrome screeningChorionic gonadotropinSyndrome pregnanciesSyndrome screeningFree beta subunitMaternal serum levelsDown syndrome pregnanciesPotential new markerFree β-subunitSerum levelsNormal controlsSensitive markerImmunoenzymometric assaySerum specimensDown syndromeGonadotropinMean levelsNew markersPreliminary dataMedianPregnancyCase levelMarkersΒ-subunit
1995
Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension.
Hsu C, Copel J, Hong S, Chan D. Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension. Obstetrics And Gynecology 1995, 86: 897-9. PMID: 7501335, DOI: 10.1016/0029-7844(95)00326-m.Peer-Reviewed Original ResearchConceptsChronic hypertensionGestational hypertensionThrombomodulin levelsSerum thrombomodulin levelsSoluble thrombomodulin antigenNormotensive control groupTwo-site enzyme-linked immunosorbentLevels of thrombomodulinNormotensive pregnant womenEnzyme-linked immunosorbentACOG criteriaHypertensive disordersSerum levelsThird trimesterNormotensive controlsPregnant womenHypertensionPreeclampsiaThrombomodulin antigenControl groupThrombomodulinWomenSignificant differencesMeaningful markersTrimester
1994
Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block.
Buyon J, Waltuck J, Caldwell K, Crawford B, Slade S, Copel J, Chan E. Relationship between maternal and neonatal levels of antibodies to 48 kDa SSB(La), 52 kDa SSA(Ro), and 60 kDa SSA(Ro) in pregnancies complicated by congenital heart block. The Journal Of Rheumatology 1994, 21: 1943-50. PMID: 7837164.Peer-Reviewed Original ResearchConceptsCongenital heart blockAnti-60Heart blockCirculation of neonatesRatios of maternalUmbilical cord levelsTotal IgG levelsMean ratioAnti-52Neonatal circulationCord levelIgG levelsMaternal antibodiesSerum levelsNeonatal levelsUnaffected pregnanciesControl groupPregnancyFetal tissuesSelective depletionAntibodiesAutoantibodiesIndirect evidenceGroupNeonates
1985
Diagnosis of ectopic pregnancy: value of the discriminatory human chorionic gonadotropin zone.
Romero R, Kadar N, Jeanty P, Copel J, Chervenak F, DeCherney A, Hobbins J. Diagnosis of ectopic pregnancy: value of the discriminatory human chorionic gonadotropin zone. Obstetrics And Gynecology 1985, 66: 357-60. PMID: 3895079.Peer-Reviewed Original ResearchConceptsIntrauterine gestational sacEctopic pregnancyHuman chorionic gonadotropinGestational sacPredictive valueSerum hCG determinationsPercent of patientsPelvic ultrasound examinationMIU/mLNegative predictive valuePositive predictive valueHCG levelsIntrauterine gestationSerum levelsProspective studyMIU/Spontaneous abortionUltrasound examinationHCG concentrationsChorionic gonadotropinHCG determinationsPregnancyPatientsSacGestation