1999
A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome risk
1998
New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age
Bahado-Singh R, Oz A, Kovanci E, Deren O, Copel J, Baumgarten A, Mahoney J. New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age. American Journal Of Obstetrics And Gynecology 1998, 179: 1627-1631. PMID: 9855608, DOI: 10.1016/s0002-9378(98)70036-5.Peer-Reviewed Original ResearchConceptsHumerus length measurementsSerum markersDown syndromeMaternal ageTriple screenHumerus lengthMultiple stepwise logistic regression analysisTriple-marker serum screeningSerum analytesStepwise logistic regression analysisScreening algorithmHigh-risk populationFetal Down syndromeMultiple serum markersDown syndrome screeningHuman chorionic gonadotropinLogistic regression analysisNew screening algorithmDown's syndrome screening efficiencyPrenatal Down syndrome screeningDown syndrome detectionFalse positive rateSerum screenSingleton fetusesUnconjugated estriol
1996
Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening
Rotmensch S, Liberati M, Kardana A, Copel J, Ben-Rafael Z, Cole L. Nicked free β-subunit of human chorionic gonadotropin: A potential new marker for Down syndrome screening. American Journal Of Obstetrics And Gynecology 1996, 174: 609-611. PMID: 8623792, DOI: 10.1016/s0002-9378(96)70435-0.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinDown syndrome screeningChorionic gonadotropinSyndrome pregnanciesSyndrome screeningFree beta subunitMaternal serum levelsDown syndrome pregnanciesPotential new markerFree β-subunitSerum levelsNormal controlsSensitive markerImmunoenzymometric assaySerum specimensDown syndromeGonadotropinMean levelsNew markersPreliminary dataMedianPregnancyCase levelMarkersΒ-subunit
1985
The effect of different human chorionic gonadotropin assay sensitivity on screening for ectopic pregnancy
Romero R, Kadar N, Copel J, Jeanty P, DeCherney A, Hobbins J. The effect of different human chorionic gonadotropin assay sensitivity on screening for ectopic pregnancy. American Journal Of Obstetrics And Gynecology 1985, 153: 72-74. PMID: 4037000, DOI: 10.1016/0002-9378(85)90593-9.Peer-Reviewed Original ResearchDiagnosis of ectopic pregnancy: value of the discriminatory human chorionic gonadotropin zone.
Romero R, Kadar N, Jeanty P, Copel J, Chervenak F, DeCherney A, Hobbins J. Diagnosis of ectopic pregnancy: value of the discriminatory human chorionic gonadotropin zone. Obstetrics And Gynecology 1985, 66: 357-60. PMID: 3895079.Peer-Reviewed Original ResearchConceptsIntrauterine gestational sacEctopic pregnancyHuman chorionic gonadotropinGestational sacPredictive valueSerum hCG determinationsPercent of patientsPelvic ultrasound examinationMIU/mLNegative predictive valuePositive predictive valueHCG levelsIntrauterine gestationSerum levelsProspective studyMIU/Spontaneous abortionUltrasound examinationHCG concentrationsChorionic gonadotropinHCG determinationsPregnancyPatientsSacGestation