2000
Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease
Bahado-Singh R, Oz U, Deren O, Kovanchi E, Hsu C, Copel J, Mari G. Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease. American Journal Of Obstetrics And Gynecology 2000, 182: 1222-1226. PMID: 10819862, DOI: 10.1016/s0002-9378(00)70189-x.Peer-Reviewed Original ResearchConceptsDoppler peak systolic velocityPeak systolic velocitySevere anemiaSystolic velocityPrior transfusionsGestational ageHemoglobin deficitStudy groupSplenic artery peak systolic velocityMean peak systolic velocityPeak systolic velocity valuesMean gestational ageOverall study groupSevere fetal anemiaCord blood specimensSystolic velocity valuesNonhydropic fetusesMean hemoglobinRhesus diseaseFetal anemiaFetal hydropsStudy populationBlood specimensNormal fetusesFirst such reportNoninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization
Mari G, Deter R, Carpenter R, Rahman F, Zimmerman R, Moise K, Dorman K, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel J, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell S. Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization. New England Journal Of Medicine 2000, 342: 9-14. PMID: 10620643, DOI: 10.1056/nejm200001063420102.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood Group IncompatibilityCordocentesisErythroblastosis, FetalErythrocytesFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornIsoantibodiesMiddle Cerebral ArteryPregnancyPregnancy Complications, HematologicProspective StudiesReference ValuesRh IsoimmunizationROC CurveSensitivity and SpecificityUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMaternal red cell alloimmunizationRed cell alloimmunizationMiddle cerebral arterySystolic blood flowCerebral arteryBlood flowSevere anemiaFetal anemiaDoppler ultrasonographyNormal fetusesHemoglobin concentrationFetal middle cerebral arteryPeak velocityFetal hemoglobin concentrationAbsence of hydropsPeak systolic velocityGestational ageModerate anemiaSystolic velocityHemoglobin valuesMild anemiaInvasive techniquesAlloimmunizationAnemiaArtery
1999
A new splenic artery Doppler velocimetric index for prediction of severe fetal anemia associated with Rh alloimmunization
Bahado-Singh R, Oz U, Deren O, Pirhonen J, Kovanci E, Copel J, Onderoglu L. A new splenic artery Doppler velocimetric index for prediction of severe fetal anemia associated with Rh alloimmunization. American Journal Of Obstetrics And Gynecology 1999, 180: 49-54. PMID: 9914577, DOI: 10.1016/s0002-9378(99)70148-1.Peer-Reviewed Original ResearchConceptsMain splenic arterySevere fetal anemiaSevere anemiaHemoglobin deficitFetal anemiaSplenic arteryGestational ageDoppler velocimetric indicesDevelopment of hydropsNew Doppler indexVelocimetric indicesCase patientsDoppler indicesRh alloimmunizationRh sensitizationHealthy fetusesAnemiaFalse positive rateNoninvasive predictionDiastolic phaseAnemia detectionDoppler velocimetrySignificant correlationArteryCordocentesis
1997
Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization
Mari G, Rahman F, Olofsson P, Ozcan T, Copel J. Increase of fetal hematocrit decreases the middle cerebral artery peak systolic velocity in pregnancies complicated by rhesus alloimmunization. The Journal Of Maternal-Fetal Medicine 1997, 6: 206-208. PMID: 9260116, DOI: 10.1002/(sici)1520-6661(199707/08)6:4<206::aid-mfm3>3.0.co;2-n.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal hematocritTime of studyIntrauterine transfusionRed blood cellsFetal anemiaRhesus alloimmunizationGestational ageRh alloimmunizationDoppler ultrasoundBlood cellsHematocritAlloimmunizationPregnancyT-testP-valueDoppler measurementsStatistical comparisonTransfusionAnemiaDiagnosisIncrease of Fetal Hematocrit Decreases the Middle Cerebral Artery Peak Systolic Velocity in Pregnancies Complicated by Rhesus Alloimmunization
Mari G, Rahman F, Olofsson P, Ozcan T, Copel J. Increase of Fetal Hematocrit Decreases the Middle Cerebral Artery Peak Systolic Velocity in Pregnancies Complicated by Rhesus Alloimmunization. The Journal Of Maternal-Fetal Medicine 1997, 6: 206-208. DOI: 10.3109/14767059709161986.Peer-Reviewed Original ResearchMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal hematocritTime of studyIntrauterine transfusionRed blood cellsFetal anemiaRhesus alloimmunizationGestational ageRh alloimmunizationDoppler ultrasoundBlood cellsHematocritAlloimmunizationPregnancyT-testP-valueDoppler measurementsStatistical comparisonTransfusionAnemiaDiagnosis
1995
Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization
Mari G, Adrignolo A, Abuhamad A, Pirhonen J, Jones D, Ludomirsky A, Copel J. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound In Obstetrics And Gynecology 1995, 5: 400-405. PMID: 7552802, DOI: 10.1046/j.1469-0705.1995.05060400.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, HemolyticBlood Flow VelocityBlood Group AntigensCerebral ArteriesCordocentesisErythroblastosis, FetalFemaleFetal BloodGestational AgeHumansInfant, NewbornObserver VariationPregnancyProspective StudiesRetrospective StudiesRh IsoimmunizationROC CurveTransfusion ReactionUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal anemiaGroup AAnemic fetusesMiddle cerebral artery peak systolic velocity valuesMiddle cerebral artery peak velocityFetal middle cerebral artery peak systolic velocityPeak systolic velocity valuesSystolic velocity valuesPeak velocityNormal mean valueAnemia riskNon-invasive methodGroup B.Prospective fashionFetal hematocritGroup BDoppler ultrasoundGroup CNormal fetusesAnemiaFetusesNormal valuesThe predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization
Moise K, Perkins J, Sosler S, Brown S, Saade G, Carpenter R, Thorp J, Ludomirski A, Wilkins I, Grannum P, Copel J. The predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization. American Journal Of Obstetrics And Gynecology 1995, 172: 1003-1009. PMID: 7892839, DOI: 10.1016/0002-9378(95)90034-9.Peer-Reviewed Original ResearchConceptsRed blood cell alloimmunizationFetal anemiaMarsh scoreReceiver operator characteristic curveCoombs titersRed blood cell antibodiesMaternal antibody titersGroups of fetusesMaternal serum testingCharacteristic curveMaternal serum testsMaternal titersCell antibodiesAntigen statusGestational agePregnant womenAntibody titersSerum testingSerum testFetal hematocritInvasive testingFetal bloodKruskal-Wallis testAnemiaFetal disease
1993
Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization.
Saade G, Moise K, Copel J, Belfort M, Carpenter R. Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization. Obstetrics And Gynecology 1993, 82: 987-91. PMID: 8233277.Peer-Reviewed Original ResearchConceptsRed cell alloimmunizationFetal platelet countPlatelet countNonhydropic fetusesBilirubin levelsReticulocyte countMaternal red cell alloimmunizationLow platelet countStudent's t-testFetal plateletsHydropic fetusesIntrauterine transfusionFetal anemiaGestational ageInitial transfusionAnemic fetusesHematopoietic stem cellsFetusesAlloimmunizationThrombocytopeniaTransfusionRegression analysisT-testAnemiaHydropic
1988
Diagnostic fetal umbilical blood sampling in the management of isoimmunization
Reece E, Copel J, Scioscia A, Grannum P, DeGennaro N, Hobbins J. Diagnostic fetal umbilical blood sampling in the management of isoimmunization. American Journal Of Obstetrics And Gynecology 1988, 159: 1057-1062. PMID: 3142263, DOI: 10.1016/0002-9378(88)90412-7.Peer-Reviewed Original ResearchConceptsAntigen-positive fetusesFetal hemolytic diseaseFetal umbilical bloodManagement of isoimmunizationEarlier gestational ageMultiple invasive proceduresIsoimmunized pregnanciesFetal anemiaAntigen statusGestational ageUmbilical bloodHemolytic diseaseFetal bloodInvasive proceduresCurrent managementFetusesPreliminary reportPregnancyIsoimmunizationDiseaseManagement protocolDiagnosisBloodLittle riskTreatmentThe reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia
Grannum P, Copel J, Moya F, Scioscia A, Robert J, Winn H, Coster B, Burdine C, Hobbins J. The reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia. American Journal Of Obstetrics And Gynecology 1988, 158: 914-919. PMID: 3284364, DOI: 10.1016/0002-9378(88)90094-4.Peer-Reviewed Original ResearchConceptsGm/dlIntrauterine intravascular transfusionIntravascular transfusionHematocrit levelsSurvival rateSevere respiratory distress syndromeReversal of hydropsOverall survival rateRespiratory distress syndromeTime of referralIntravascular intrauterine transfusionSevere erythroblastosis fetalisTotal proteinIntrauterine transfusionNeonatal morbidityErythroblastosis fetalisHydropic fetusesDistress syndromeFetal anemiaExchange transfusionNeonatal deathIntraperitoneal transfusionSevere erythroblastosisNewborn periodIntravascular treatment