2024
Case Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi
Dos Santos N, da Silva Bastos A, Araújo J, Pontual J, Medeiros J, Vinetz J, da Silva Araujo M. Case Report: Plasmodium vivax Sporozoite Melanization in the Midgut and Salivary Gland of the Malaria Vector Anopheles darlingi. American Journal Of Tropical Medicine And Hygiene 2024, 110: 444-447. PMID: 38350139, PMCID: PMC10919193, DOI: 10.4269/ajtmh.23-0349.Peer-Reviewed Original ResearchResponses to P. vivaxPlasmodium falciparum parasitesPrimary malaria vectorPlasmodium vivaxVector Anopheles darlingiFalciparum parasitesMalaria parasitesMalaria vector Anopheles darlingiPlasmodium parasitesSalivary glandsMalaria vectorsPlasmodiumAnopheline mosquitoesAnopheles darlingiMalariaDarlingiVivaxSalivaryGland
2023
Natural Infection of Nyssorhynchus darlingi and Nyssorhynchus benarrochi B with Plasmodium during the Dry Season in the Understudied Low-Transmission Setting of Datem del Marañon Province, Amazonian Peru
Conn J, Bickersmith S, Saavedra M, Morales J, Alava F, Rodriguez G, del Aguila Morante C, Tong C, Alvarez-Antonio C, Huanahui J, Vinetz J, Gamboa D. Natural Infection of Nyssorhynchus darlingi and Nyssorhynchus benarrochi B with Plasmodium during the Dry Season in the Understudied Low-Transmission Setting of Datem del Marañon Province, Amazonian Peru. American Journal Of Tropical Medicine And Hygiene 2023, 109: 288-295. PMID: 37364858, PMCID: PMC10397451, DOI: 10.4269/ajtmh.23-0058.Peer-Reviewed Original ResearchConceptsLow transmission settingsAnnual parasite indexEntomological inoculation rateHuman biting rateHuman landing catchesMinistry of HealthMalaria hotspotsInfective bitesPlasmodium vivaxMalaria transmissionLanding catchesPlasmodium falciparumMalaria researchNatural infectionInoculation rateNyssorhynchus darlingiBiting rateRiverine villagesParasite indexBiteVector control unitsDarlingiLoreto DepartmentInfectionVivaxTransmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
Andrade A, Santos N, Bastos A, Pontual J, Araújo J, Silva A, Martinez L, Lima A, Aguiar A, Teles C, Medeiros J, Pereira D, Vinetz J, Gazzinelli R, Araújo M. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLOS Neglected Tropical Diseases 2023, 17: e0011425. PMID: 37327209, PMCID: PMC10310017, DOI: 10.1371/journal.pntd.0011425.Peer-Reviewed Original ResearchConceptsDensity of gametocytesTransmission-blocking efficacyPlasmodium vivax malariaTransmission-blocking activityImportant infectious diseasesOne-doseVivax malariaP. vivaxMosquito infectionPlasmodium vivaxTreatment groupsPatient's bloodGametocyte productionMalaria transmissionInfectious diseasesGenus PlasmodiumMalariaTreatmentChloroquinePrimaquineVivaxBloodDirect membraneBiological characteristicsMosquitoes
2022
Malaria transmission structure in the Peruvian Amazon through antibody signatures to Plasmodium vivax
Rosado J, Carrasco-Escobar G, Nolasco O, Garro K, Rodriguez-Ferruci H, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Nekkab N, White MT, Mueller I, Gamboa D. Malaria transmission structure in the Peruvian Amazon through antibody signatures to Plasmodium vivax. PLOS Neglected Tropical Diseases 2022, 16: e0010415. PMID: 35533146, PMCID: PMC9119515, DOI: 10.1371/journal.pntd.0010415.Peer-Reviewed Original ResearchConceptsSerological exposure markersP. vivaxMalaria transmissionAntibody levelsRecent exposureRoutine malaria surveillanceHigher antibody levelsCross-sectional surveyLight microscopySeropositive casesAntibody signaturesPast infectionRisk factorsPrevalence surveyHigher oddsMalaria surveillanceExposure markersElimination effortsSignificant associationSocio-DemographicEpidemiological analysisSerological surveillanceParticular epidemiologyLocal transmissionVivax
2018
Asymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination
Martin TCS, Vinetz JM. Asymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination. Malaria Journal 2018, 17: 89. PMID: 29466991, PMCID: PMC5822557, DOI: 10.1186/s12936-018-2243-3.Peer-Reviewed Original ResearchConceptsTransmission-blocking vaccinesPlasmodium vivax parasitaemiaLow transmission settingsControl of transmissionVivax parasitaemiaChloroquine resistanceAsymptomatic carriageMalaria eliminationNew therapiesPlasmodium vivaxImportant causeCarrier stateImmunological interactionsVaccineOnward infectionInfectionParasite transmissionEradication effortsMosquitoesMorbidityParasitaemiaTherapyMortalityDiagnosisVivax
2016
Epidemiology of Plasmodium vivax Malaria in Peru
Rosas-Aguirre A, Gamboa D, Manrique P, Conn JE, Moreno M, Lescano AG, Sanchez JF, Rodriguez H, Silva H, Llanos-Cuentas A, Vinetz JM. Epidemiology of Plasmodium vivax Malaria in Peru. American Journal Of Tropical Medicine And Hygiene 2016, 95: 133-144. PMID: 27799639, PMCID: PMC5201219, DOI: 10.4269/ajtmh.16-0268.Peer-Reviewed Original ResearchConceptsMalaria transmissionP. vivaxMalaria controlPlasmodium falciparum malaria casesMicroscopy-confirmed casesP. vivax malaria transmissionFalciparum malaria casesPlasmodium vivax malariaVivax malaria transmissionPublic health problemGlucose-6-phosphate dehydrogenase deficiencyFuture malaria controlImplementation of surveillanceCombination therapyVivax malariaClinical trialsMalaria casesPlasmodium vivaxElimination effortsHealth problemsP. falciparumMosquito transmissionDehydrogenase deficiencyVivaxOngoing surveillance activities
2006
314 EXPERIMENTAL INFECTION OF ANOPHELES DARLINGI MOSQUITOES BY PLASMODIUM VIVAX FROM NATURALLY INFECTED PATIENTS IN THE PERUVIAN AMAZON.
Bharti A, Chuquiyauri R, Segura E, Lopez V, Stancil J, Llanos A, Vinetz J. 314 EXPERIMENTAL INFECTION OF ANOPHELES DARLINGI MOSQUITOES BY PLASMODIUM VIVAX FROM NATURALLY INFECTED PATIENTS IN THE PERUVIAN AMAZON. Journal Of Investigative Medicine 2006, 54: s134. DOI: 10.2310/6650.2005.x0004.313.Peer-Reviewed Original ResearchP. vivaxPlasmodium vivaxP. vivax infectionIncidence of malariaLife-threatening diseaseTransmission of infectionOocyst loadMembrane feeding techniqueSymptomatic patientsArtificial membrane feeding techniqueVivax malariaVivax infectionInterventional methodsPatientsInfected mosquitoesExperimental infectionDarlingi mosquitoesMosquito midgutVivaxAlternative interventionsInfectionMicroscopic examinationCurrent control measuresInfected midgutsMalariaExperimental Infection of Anopheles Darlingi Mosquitoes by Plasmodium Vivax From Naturally Infected Patients in the Peruvian Amazon
Bharti A, Chuquiyauri R, Segura E, Lopez V, Stancil J, Llanos A, Vinetz J. Experimental Infection of Anopheles Darlingi Mosquitoes by Plasmodium Vivax From Naturally Infected Patients in the Peruvian Amazon. Journal Of Investigative Medicine 2006, 54: 134-134. DOI: 10.1177/108155890605401s197.Peer-Reviewed Original Research