2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settings
2005
Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden
Segura ER, Ganoza CA, Campos K, Ricaldi JN, Torres S, Silva H, Céspedes MJ, Matthias MA, Swancutt MA, Liñán R, Gotuzzo E, Guerra H, Gilman RH, Vinetz JM, Consortium P. Clinical Spectrum of Pulmonary Involvement in Leptospirosis in a Region of Endemicity, with Quantification of Leptospiral Burden. Clinical Infectious Diseases 2005, 40: 343-351. PMID: 15668855, PMCID: PMC2366057, DOI: 10.1086/427110.Peer-Reviewed Original ResearchConceptsPulmonary involvementFebrile patientsAcute respiratory distress syndromeMost fatal casesSevere pulmonary manifestationsRespiratory distress syndromePopulation-based studyEvidence of exposureDiagnosis of leptospirosisRegions of endemicityPulmonary complicationsMultiorgan failurePulmonary manifestationsPresumptive treatmentDistress syndromePulmonary hemorrhageSerologic testingIgM antibodiesClinical spectrumPulmonary casesFatal casesQuantitative real-time PCRReal-time PCRAntileptospiral antibodiesLeptospiral burden