2021
State dependent effects on the frequency response of prestin’s real and imaginary components of nonlinear capacitance
Santos-Sacchi J, Navaratnam D, Tan WJT. State dependent effects on the frequency response of prestin’s real and imaginary components of nonlinear capacitance. Scientific Reports 2021, 11: 16149. PMID: 34373481, PMCID: PMC8352928, DOI: 10.1038/s41598-021-95121-4.Peer-Reviewed Original Research
2019
Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti
Bai JP, Navaratnam D, Santos-Sacchi J. Prestin kinetics and corresponding frequency dependence augment during early development of the outer hair cell within the mouse organ of Corti. Scientific Reports 2019, 9: 16460. PMID: 31712635, PMCID: PMC6848539, DOI: 10.1038/s41598-019-52965-1.Peer-Reviewed Original ResearchConceptsOuter hair cellsPostnatal dayVoltage-sensor charge movementAltricial animalsPostnatal developmentCochlear placeElectrical correlatesHair cellsMouse organsCochlear amplificationEarly developmentAuditory frequencyPrestin activityAuditory capabilitiesCellsCharge movementHigh frequencyResponse increasesPrestin functionMiceActivityMonthsCourse
2018
The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin
Santos-Sacchi J, Tan W. The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin. Journal Of Neuroscience 2018, 38: 5495-5506. PMID: 29899032, PMCID: PMC6001036, DOI: 10.1523/jneurosci.0425-18.2018.Peer-Reviewed Original ResearchConceptsFrequency responseVoltage excitationNonlinear capacitanceFlat frequency responseLow-pass behaviorInterrogation frequencyMechanical responsePiezoelectric couplingCutoff frequencyLow-pass characteristicsLow passElectrical signatureLimiting timeOrders of magnitudeAmplification gainCochlear amplificationKHzΜsMembrane protein prestinVoltageKineticsCapacitanceDamage resultsPhase correspondsElectrical
2016
Chloride Anions Regulate Kinetics but Not Voltage-Sensor Q max of the Solute Carrier SLC26a5
Santos-Sacchi J, Song L. Chloride Anions Regulate Kinetics but Not Voltage-Sensor Q max of the Solute Carrier SLC26a5. Biophysical Journal 2016, 110: 2551-2561. PMID: 27276272, PMCID: PMC4906268, DOI: 10.1016/j.bpj.2016.05.002.Peer-Reviewed Original Research
2013
IR Laser-Induced Perturbations of the Voltage-Dependent Solute Carrier Protein SLC26a5
Okunade O, Santos-Sacchi J. IR Laser-Induced Perturbations of the Voltage-Dependent Solute Carrier Protein SLC26a5. Biophysical Journal 2013, 105: 1822-1828. PMID: 24138858, PMCID: PMC3797594, DOI: 10.1016/j.bpj.2013.09.008.Peer-Reviewed Original ResearchDisparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5
Song L, Santos-Sacchi J. Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3883-3888. PMID: 23431177, PMCID: PMC3593883, DOI: 10.1073/pnas.1218341110.Peer-Reviewed Original Research
2009
Fast Electromechanical Amplification in the Lateral Membrane of the Outer Hair Cell
Santos-Sacchi J, Navarrete E, Song L. Fast Electromechanical Amplification in the Lateral Membrane of the Outer Hair Cell. Biophysical Journal 2009, 96: 739-747. PMID: 19167318, PMCID: PMC2716482, DOI: 10.1016/j.bpj.2008.10.015.Peer-Reviewed Original Research
1995
Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge
Kakehata S, Santos-Sacchi J. Membrane tension directly shifts voltage dependence of outer hair cell motility and associated gating charge. Biophysical Journal 1995, 68: 2190-2197. PMID: 7612863, PMCID: PMC1282124, DOI: 10.1016/s0006-3495(95)80401-7.Peer-Reviewed Original ResearchConceptsIntracellular turgor pressureCortical cytoskeletal networkIntracellular pressureOuter hair cellsCytoskeletal networkCell motilityMammalian basilar membraneCytoskeletal elementsTurgor pressureOHC motorMembrane tensionCell collapseMechanical vibrationNonlinear capacitanceVoltage-dependent capacitanceHair cell motilityGating chargeHair cellsCell configurationCapacitanceMembrane stressOuter hair cell motilityWhole-cell voltage-clamp configurationMotility
1993
Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear
Santos-Sacchi J. Voltage-dependent ionic conductances of type I spiral ganglion cells from the guinea pig inner ear. Journal Of Neuroscience 1993, 13: 3599-3611. PMID: 8393487, PMCID: PMC6576533, DOI: 10.1523/jneurosci.13-08-03599.1993.Peer-Reviewed Original ResearchConceptsType I spiral ganglion cellsSpiral ganglion cellsOutward K currentsGuinea pig inner earGanglion cellsK currentsSpiral ganglion cell somataTTX-sensitive Na currentsInner earGanglion cell somataSpontaneous spike activityWhole-cell voltage clampNa currentIntrinsic membrane propertiesInner hair cellsSingle-unit studiesSingle-unit activityHalf-maximal amplitudeAfferent innervationCochlear nucleusIntrinsic electrical propertiesVoltage-dependent ionic conductancesCell somataExtracellular ionic environmentSpike activity
1992
On the frequency limit and phase of outer hair cell motility: effects of the membrane filter
Santos-Sacchi J. On the frequency limit and phase of outer hair cell motility: effects of the membrane filter. Journal Of Neuroscience 1992, 12: 1906-1916. PMID: 1578277, PMCID: PMC6575887, DOI: 10.1523/jneurosci.12-05-01906.1992.Peer-Reviewed Original Research