2004
On Membrane Motor Activity and Chloride Flux in the Outer Hair Cell: Lessons Learned from the Environmental Toxin Tributyltin
Song L, Seeger A, Santos-Sacchi J. On Membrane Motor Activity and Chloride Flux in the Outer Hair Cell: Lessons Learned from the Environmental Toxin Tributyltin. Biophysical Journal 2004, 88: 2350-2362. PMID: 15596517, PMCID: PMC1305283, DOI: 10.1529/biophysj.104.053579.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCell MovementCells, CulturedChlorineDose-Response Relationship, DrugGuinea PigsHair Cells, Auditory, OuterHazardous SubstancesMolecular Motor ProteinsTrialkyltin CompoundsConceptsLateral membranesCell’s mechanical activityOuter hair cellsMammalian cochlear amplifierHair cellsMembrane motorMarine mammalsIntact outer hair cellsPotent abilityFood chainNonselective conductanceCl(-) homeostasisPrestinNanomolar concentrationsExtracellular Cl- concentrationCl fluxMembraneCellsNew environmental threatsMammalsChloride effectTributyltinEnvironmental threatsHomeostasisNonlinear capacitance
1996
Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge
Kakehata S, Santos-Sacchi J. Effects of Salicylate and Lanthanides on Outer Hair Cell Motility and Associated Gating Charge. Journal Of Neuroscience 1996, 16: 4881-4889. PMID: 8756420, PMCID: PMC6579298, DOI: 10.1523/jneurosci.16-16-04881.1996.Peer-Reviewed Original ResearchConceptsOuter hair cellsEffects of salicylateConcentration-response curvesGuinea pig outer hair cellsOHC motilityAuditory frequency selectivityForm of salicylateHalf-maximal concentrationReversible tinnitusHearing lossDepolarized levelsHair cell motilityComparable groupsHair cellsOuter Hair Cell MotilityInner aspectOuter aspectSubsurface cisternaeTrypsin treatmentMotilityPressure changesHill coefficientSalicylatePresent experimentsVoltage-induced movement