2019
Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice
El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK. Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice. Journal Of Neuroscience 2019, 39: 4797-4813. PMID: 30936239, PMCID: PMC6561694, DOI: 10.1523/jneurosci.0839-18.2019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysAuditory PerceptionBrain StemCochlear NucleusElectrophysiological PhenomenaEvoked Potentials, Auditory, Brain StemFemaleFragile X Mental Retardation ProteinFragile X SyndromeHydantoinsIn Vitro TechniquesMaleMiceMice, KnockoutPatch-Clamp TechniquesPyridinesShaw Potassium ChannelsConceptsAuditory brainstem responseWild-type animalsRepetitive firingABR wave ICurrent-clamp recordingsAuditory brainstem nucleiVoltage-clamp recordingsHigh-frequency firingSingle action potentialFragile X syndromeTrapezoid bodyBrainstem nucleiBrainstem responseMedial nucleusAuditory brainstemAuditory nerveWave IWave IVAction potentialsSensory stimuliKv3.1 channelsCentral processingMental retardation proteinHigh sound levelsMice
2015
An Electrical Inspection of the Subsurface Cisternae of the Outer Hair Cell
Song L, Santos-Sacchi J. An Electrical Inspection of the Subsurface Cisternae of the Outer Hair Cell. Biophysical Journal 2015, 108: 568-577. PMID: 25650924, PMCID: PMC4317539, DOI: 10.1016/j.bpj.2014.12.010.Peer-Reviewed Original ResearchAnimalsElectrodesElectrophysiological PhenomenaGuinea PigsHair Cells, Auditory, OuterModels, BiologicalPatch-Clamp TechniquesTime Factors
2013
Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5
Song L, Santos-Sacchi J. Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3883-3888. PMID: 23431177, PMCID: PMC3593883, DOI: 10.1073/pnas.1218341110.Peer-Reviewed Original ResearchPatch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish
Ricci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J. Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish. Journal Of Neuroscience 2013, 33: 3131-3134. PMID: 23407967, PMCID: PMC3684625, DOI: 10.1523/jneurosci.4265-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsElectrophysiological PhenomenaFemaleFunctional LateralityGap JunctionsHair Cells, AuditoryLarvaLateral Line SystemMaleNeuronsPatch-Clamp TechniquesPotassium ChannelsSynaptic VesiclesZebrafishConceptsHair cellsSynaptic vesicle releaseNeuromast hair cellsLiving zebrafishBiological discoveryIonic channel activityZebrafishVesicle releaseChannel activityPhysiological activityLateral lineJunctional couplingCellsDetailed understandingPatch-clamp recordingsVestibular peripheryFishNeuromastsActivityDiscoveryFirst recording