2013
Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5
Song L, Santos-Sacchi J. Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3883-3888. PMID: 23431177, PMCID: PMC3593883, DOI: 10.1073/pnas.1218341110.Peer-Reviewed Original Research
2006
En block C-terminal charge cluster reversals in prestin (SLC26A5): Effects on voltage-dependent electromechanical activity
Bai JP, Navaratnam D, Samaranayake H, Santos-Sacchi J. En block C-terminal charge cluster reversals in prestin (SLC26A5): Effects on voltage-dependent electromechanical activity. Neuroscience Letters 2006, 404: 270-275. PMID: 16839688, DOI: 10.1016/j.neulet.2006.05.062.Peer-Reviewed Original Research
2001
Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane
Takahashi S, Santos-Sacchi J. Non-uniform mapping of stress-induced, motility-related charge movement in the outer hair cell plasma membrane. Pflügers Archiv - European Journal Of Physiology 2001, 441: 506-513. PMID: 11212214, DOI: 10.1007/s004240000455.Peer-Reviewed Original ResearchConceptsCell plasma membranePlasma membraneLateral membranesOuter hair cell plasma membraneVoltage-dependent motilityMammalian cochlear amplifierOuter hair cell electromotilityMembrane microdomainsGating currentsHair cell electromotilityTurgor pressureOHC motorMolecular motorsElectromotile responseMembraneMotilityCytoskeletonCharge movementBell-shaped distributionMicrodomainsElectromotilityNon-uniform mappingPronase treatmentCochlear amplifierPronase
1999
Auditory collusion and a coupled couple of outer hair cells
Zhao H, Santos-Sacchi J. Auditory collusion and a coupled couple of outer hair cells. Nature 1999, 399: 359-362. PMID: 10360573, DOI: 10.1038/20686.Peer-Reviewed Original Research
1993
Harmonics of outer hair cell motility
Santos-Sacchi J. Harmonics of outer hair cell motility. Biophysical Journal 1993, 65: 2217-2227. PMID: 8298045, PMCID: PMC1225953, DOI: 10.1016/s0006-3495(93)81247-5.Peer-Reviewed Original ResearchMapping the distribution of the outer hair cell motility voltage sensor by electrical amputation
Huang G, Santos-Sacchi J. Mapping the distribution of the outer hair cell motility voltage sensor by electrical amputation. Biophysical Journal 1993, 65: 2228-2236. PMID: 8298046, PMCID: PMC1225954, DOI: 10.1016/s0006-3495(93)81248-7.Peer-Reviewed Original Research
1989
Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti
Santos-Sacchi J. Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti. Journal Of Neuroscience 1989, 9: 2954-2962. PMID: 2769373, PMCID: PMC6569687, DOI: 10.1523/jneurosci.09-08-02954.1989.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaCell MovementCell SeparationElectric ConductivityElectrophysiologyGuinea PigsHair Cells, AuditoryOrgan of CortiConceptsOuter hair cellsWhole-cell voltage-clamp techniqueHair cellsNormal resting potentialsOrgan of CortiVoltage-clamp techniqueCell shorteningAcoustic stimulationReceptor potentialResting potentialsResponse magnitudeOHC movementsReported productionStimulationHyperpolarizationComparable levelsNeural tuningCell length changesDepolarizationLength changesCellsBasilar membraneVoltage stimulation