2017
Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility
Santos-Sacchi J, Navaratnam D, Raphael R, Oliver D. Prestin: Molecular Mechanisms Underlying Outer Hair Cell Electromotility. Springer Handbook Of Auditory Research 2017, 62: 113-145. DOI: 10.1007/978-3-319-52073-5_5.Peer-Reviewed Original ResearchOuter hair cellsMammalian inner earOuter Hair Cell ElectromotilityHair cell electromotilitySLC26 familyMolecular mechanismsMembrane lipidsConformational changesMechanical feedback mechanismMolecular motorsTension sensitivityPrestinHair cellsVoltage-sensor charge movementAnion transportersReceptor potentialProteinMolecular conformational changesInner earStructural determinationIntracellular chlorideCharge movementTraffickingFeedback mechanismMechanism
2011
Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's Organ
Song L, Santos-Sacchi J, Shera C, Olson E. Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's Organ. AIP Conference Proceedings 2011, 1403: 179-184. DOI: 10.1063/1.3658083.Peer-Reviewed Original ResearchCellular mechanicsConformational changesMotor protein prestinProtein prestinMolecular eventsLateral membranesOHC lateral membraneCellular expressionWhole cellsElectromotilityOuter Hair CellsPrestinHair cellsReceptor potentialNonlinear capacitanceMolecular conformational changesIntracellular chloride levelsCellsTight couplingOrgansOHC receptor potentialsExpressionMembraneNormal levelsVivo
1989
Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti
Santos-Sacchi J. Asymmetry in voltage-dependent movements of isolated outer hair cells from the organ of Corti. Journal Of Neuroscience 1989, 9: 2954-2962. PMID: 2769373, PMCID: PMC6569687, DOI: 10.1523/jneurosci.09-08-02954.1989.Peer-Reviewed Original ResearchConceptsOuter hair cellsWhole-cell voltage-clamp techniqueHair cellsNormal resting potentialsOrgan of CortiVoltage-clamp techniqueCell shorteningAcoustic stimulationReceptor potentialResting potentialsResponse magnitudeOHC movementsReported productionStimulationHyperpolarizationComparable levelsNeural tuningCell length changesDepolarizationLength changesCellsBasilar membraneVoltage stimulation
1982
Intracellular Recordings from Cochlear Outer Hair Cells
Dallos P, Santos-Sacchi J, Flock Å. Intracellular Recordings from Cochlear Outer Hair Cells. Science 1982, 218: 582-584. PMID: 7123260, DOI: 10.1126/science.7123260.Peer-Reviewed Original Research