2019
Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best
Santos-Sacchi J, Tan W. Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best. IScience 2019, 22: 392-399. PMID: 31812809, PMCID: PMC6911985, DOI: 10.1016/j.isci.2019.11.036.Peer-Reviewed Original Research
2011
Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's Organ
Song L, Santos-Sacchi J, Shera C, Olson E. Chloride Dependent Coupling of Molecular to Cellular Mechanics in the Outer Hair Cell of Corti's Organ. AIP Conference Proceedings 2011, 1403: 179-184. DOI: 10.1063/1.3658083.Peer-Reviewed Original ResearchCellular mechanicsConformational changesMotor protein prestinProtein prestinMolecular eventsLateral membranesOHC lateral membraneCellular expressionWhole cellsElectromotilityOuter Hair CellsPrestinHair cellsReceptor potentialNonlinear capacitanceMolecular conformational changesIntracellular chloride levelsCellsTight couplingOrgansOHC receptor potentialsExpressionMembraneNormal levelsVivoThe magnificent outer hair cell of Corti's organ
Santos-Sacchi J. The magnificent outer hair cell of Corti's organ. Otology Japan 2011, 9: 111-115. DOI: 10.11289/otoljpn1991.9.111.Peer-Reviewed Original Research
2008
Anion Control of Voltage Sensing by the Motor Protein Prestin in Outer Hair Cells
Rybalchenko V, Santos-Sacchi J. Anion Control of Voltage Sensing by the Motor Protein Prestin in Outer Hair Cells. Biophysical Journal 2008, 95: 4439-4447. PMID: 18658219, PMCID: PMC2567960, DOI: 10.1529/biophysj.108.134197.Peer-Reviewed Original ResearchConceptsOuter hair cellsHair cellsCochlear amplificationSLC26 anion transporter familyMotor protein prestinMammalian cochlear amplificationVoltage-sensor charge movementAuditory responsivenessCorti's organAnion transporter familyTransporter familyProtein prestinMolecular motorsCharge movementPrestinOrgansCellsComplicated roleVoltage sensing
2003
New tunes from Corti’s organ: the outer hair cell boogie rules
Santos-Sacchi J. New tunes from Corti’s organ: the outer hair cell boogie rules. Current Opinion In Neurobiology 2003, 13: 459-468. PMID: 12965294, DOI: 10.1016/s0959-4388(03)00100-4.Peer-Reviewed Original ResearchConceptsSpecial cell typesHair cellsOuter hair cell electromotilityHair cell electromotilityMolecular identificationCell typesMammalsMechanism of actionOuter hair cellsAdditional mechanismVertebratesCellsAmplificationMechanismKnockoutElectromotilityOrgansSuch amplificationCorti's organAcoustic stimuliRemarkable progress
2000
Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ
Blasits S, Maune S, Santos-Sacchi J. Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ. Pflügers Archiv - European Journal Of Physiology 2000, 440: 710-712. PMID: 11007311, DOI: 10.1007/s004240000355.Peer-Reviewed Original ResearchConceptsDeiters' cellsCorti's organNO/cGMP pathwayNitric oxide donor sodium nitroprussideWhole-cell voltage-clamp conditionsNO synthase inhibitorUncouple gap junctionsNormal sensory functionDonor sodium nitroprussideGap junctionsVoltage-clamp conditionsOtotoxic mechanismsMinutes of applicationCGMP pathwayGap junctional communicationSodium nitroprussideSynthase inhibitorCochlear homeostasisSensory functionElectrical uncouplingNitric oxideCGMP analogJunctional communicationOrgansCellsCell coupling in Corti's organ
Santos-Sacchi J. Cell coupling in Corti's organ. Brain Research Reviews 2000, 32: 167-171. PMID: 10751666, DOI: 10.1016/s0165-0173(99)00077-6.Peer-Reviewed Original Research
1994
Cell coupling in the supporting cells of Corti's organ: Sensitivity to intracellular H+ and Ca+2
Sato Y, Santos-Sacchi J. Cell coupling in the supporting cells of Corti's organ: Sensitivity to intracellular H+ and Ca+2. Hearing Research 1994, 80: 21-24. PMID: 7852199, DOI: 10.1016/0378-5955(94)90004-3.Peer-Reviewed Original Research
1991
Isolated supporting cells from the organ of Corti: Some whole cell electrical characteristics and estimates of gap junctional conductance
Santos-Sacchi J. Isolated supporting cells from the organ of Corti: Some whole cell electrical characteristics and estimates of gap junctional conductance. Hearing Research 1991, 52: 89-98. PMID: 2061216, DOI: 10.1016/0378-5955(91)90190-k.Peer-Reviewed Original ResearchConceptsInput resistanceWhole-cell voltage clamp studiesAverage input resistanceHensen's cellsOrgan of CortiVoltage-clamp studiesGuinea pig organJunctional resistanceClamp studiesCell levelPig organsSingle-cell levelGap junctional conductanceG omegaElectrical activityExternal TEACell couplingCortiJunctional conductanceCellsOrgansSensitive indicatorSmall groupCell values
1987
Electrical coupling differs in the in vitro and in vivo organ of Corti
Santos-Sacchi J. Electrical coupling differs in the in vitro and in vivo organ of Corti. Hearing Research 1987, 25: 227-232. PMID: 3558131, DOI: 10.1016/0378-5955(87)90094-3.Peer-Reviewed Original ResearchConceptsOrgan of CortiBony cochleaVivo preparationInner earLateral wallGuinea pig organAnesthetized animalsPig organsStria vascularisEndolymphatic potentialCortiReissner's membraneMedium 199Perfusion chamberCochleaVivo experimentsApical sideOrgansKCl electrodesM KCl electrodesElectrical couplingUnique microenvironmentCellsEarThird turn
1986
Dye coupling in the organ of Corti
Santos-Sacchi J. Dye coupling in the organ of Corti. Cell And Tissue Research 1986, 245: 525-529. PMID: 3757014, PMCID: PMC6042516, DOI: 10.1007/bf00218553.Peer-Reviewed Original Research
1985
The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti
Santos-Sacchi J. The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti. Hearing Research 1985, 19: 207-215. PMID: 3934121, DOI: 10.1016/0378-5955(85)90140-6.Peer-Reviewed Original Research
1984
A re-evaluation of cell coupling in the organ of Corti
Santos-Sacchi J. A re-evaluation of cell coupling in the organ of Corti. Hearing Research 1984, 14: 203-204. PMID: 6746433, DOI: 10.1016/0378-5955(84)90019-4.Peer-Reviewed Original Research
1983
Intercellular communication in the supporting cells of the organ of Corti
Santos-Sacchi J, Dallos P. Intercellular communication in the supporting cells of the organ of Corti. Hearing Research 1983, 9: 317-326. PMID: 6841286, DOI: 10.1016/0378-5955(83)90034-5.Peer-Reviewed Original Research
1982
Determination of cochlear receptor potential characteristics by pseudorandom noise
Dallos P, Santos-Sacchi J, Lutz W. Determination of cochlear receptor potential characteristics by pseudorandom noise. The Journal Of The Acoustical Society Of America 1982, 71: s17-s17. DOI: 10.1121/1.2019254.Peer-Reviewed Original Research