Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress
Tan W, Santos-Sacchi J, Tonello J, Shanker A, Ivanova A. Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress. Antioxidants 2023, 12: 1225. PMID: 37371955, PMCID: PMC10294946, DOI: 10.3390/antiox12061225.Peer-Reviewed Original ResearchPharmacological modulationKO miceMitochondrial metabolismComparative gene expression analysisMetabolic pathwaysOxidative stressCritical biological processesHearing-related genesDrug-specific responsesPremature hearing lossGene expression analysisAdrenal axisHearing lossImmune responseMitochondrial morphologyMotor proteinsExpression analysisVoltage-gated channelsBiological processesMTOR pathwayNormal hearingPronounced upregulationMolecular pathwaysMitochondrial activityEnergy sensing