2023
Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress
Tan W, Santos-Sacchi J, Tonello J, Shanker A, Ivanova A. Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress. Antioxidants 2023, 12: 1225. PMID: 37371955, PMCID: PMC10294946, DOI: 10.3390/antiox12061225.Peer-Reviewed Original ResearchPharmacological modulationKO miceMitochondrial metabolismComparative gene expression analysisMetabolic pathwaysOxidative stressCritical biological processesHearing-related genesDrug-specific responsesPremature hearing lossGene expression analysisAdrenal axisHearing lossImmune responseMitochondrial morphologyMotor proteinsExpression analysisVoltage-gated channelsBiological processesMTOR pathwayNormal hearingPronounced upregulationMolecular pathwaysMitochondrial activityEnergy sensing
2010
Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of Proliferation
Frucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of Proliferation. PLOS ONE 2010, 5: e11502. PMID: 20634979, PMCID: PMC2901389, DOI: 10.1371/journal.pone.0011502.Peer-Reviewed Original ResearchConceptsNew hair cellsAuditory epitheliumChicken auditory epitheliumHair cellsInner ear developmentHair cell regenerationGene expression analysisAuditory hair cellsEar developmentExpression analysisMyosin VIEnrichment analysisCycle controlGene expressionMolecular eventsSingle microRNAMediator of proliferationRelevant pathwaysFunctional experimentsPost-hatch chicksRegenerating tissueMammalsGenesBrdU incorporationCell regeneration