Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium
Frucht CS, Uduman M, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium. Journal Of The Association For Research In Otolaryngology 2011, 12: 423-435. PMID: 21399991, PMCID: PMC3123449, DOI: 10.1007/s10162-011-0259-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalcium ChannelsChickensCyclic AMP-Dependent Protein KinasesGene Expression ProfilingGene Expression Regulation, DevelopmentalHair Cells, AuditoryLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMicroRNAsModels, AnimalOrgan of CortiProtein Kinase CSodium ChannelsConceptsGene expression gradientsAuditory epitheliumKinases protein kinase CChicken auditory epitheliumExpression gradientsAvian auditory epitheliumBasilar papillaFold-change cutoffActivity of kinasesIon channel genesProtein kinase CChicken basilar papillaGene setsGenetic basisEnrichment analysisExpression patternsGene expressionGeneSpring softwareChannel genesMechanism of inductionKinase CGenesMicroarray dataDifferential activityQuantitative PCRMicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium
Frucht CS, Santos-Sacchi J, Navaratnam DS. MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium. Neuroscience Letters 2011, 493: 44-48. PMID: 21316421, PMCID: PMC3065390, DOI: 10.1016/j.neulet.2011.02.017.Peer-Reviewed Original ResearchConceptsHair cell regenerationHair cell deathAuditory epitheliumChicken auditory epitheliumCell deathNon-mammalian vertebratesAvian auditory epitheliumCell regenerationHair cellsBasilar papillaNew hair cellsChicken basilar papillaAvian counterpartsOtotoxic injuryCaspase-3MiRNACellsMiR181aKey roleExplantsProliferationRegenerationBrdU-positive cellsVertebratesMammals