Longitudinal analysis of the lung microbiota of cynomolgous macaques during long-term SHIV infection
Morris A, Paulson J, Talukder H, Tipton L, Kling H, Cui L, Fitch A, Pop M, Norris K, Ghedin E. Longitudinal analysis of the lung microbiota of cynomolgous macaques during long-term SHIV infection. Microbiome 2016, 4: 38. PMID: 27391224, PMCID: PMC4939015, DOI: 10.1186/s40168-016-0183-0.Peer-Reviewed Original ResearchConceptsDevelopment of obstructive lung diseaseObstructive lung diseaseNon-human primate modelLung microbiomeSHIV infectionLung microbiotaRibosomal RNALung diseasePrimate modelNon-obstructive groupSHIV-infected animalsResponse to immunosuppressionBronchoalveolar lavage fluid samplesCynomolgous macaquesDevelopment of obstructive diseaseLavage fluid samplesMultiple other speciesSIV-HIVOral anaerobesOral bacteriaTropheryma whippleiObstructive diseaseCommunity compositionBacterial communitiesDisease onsetIndividual-specific changes in the human gut microbiota after challenge with enterotoxigenic Escherichia coli and subsequent ciprofloxacin treatment
Pop M, Paulson J, Chakraborty S, Astrovskaya I, Lindsay B, Li S, Bravo H, Harro C, Parkhill J, Walker A, Walker R, Sack D, Stine O. Individual-specific changes in the human gut microbiota after challenge with enterotoxigenic Escherichia coli and subsequent ciprofloxacin treatment. BMC Genomics 2016, 17: 440. PMID: 27277524, PMCID: PMC4898365, DOI: 10.1186/s12864-016-2777-0.Peer-Reviewed Original ResearchConceptsGene sequencesBackgroundEnterotoxigenic Escherichia coliHuman gut microbiotaRRNA gene sequencesEnterotoxigenic Escherichia coliHuman intestinal microbiotaFecal E. coliCiprofloxacin treatmentETEC infectionETEC diarrheaRibosomal RNAGut microbiotaFecal microbiotaIntestinal microbiotaE. coliMicrobiotaMonthly follow-up visitsCompared to variationsETECFollow-up visitQuantitative PCRHuman challenge studiesCiprofloxacinQuantitative culturesSequence