2016
Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices
Calle EA, Hill RC, Leiby KL, Le AV, Gard AL, Madri JA, Hansen KC, Niklason LE. Targeted proteomics effectively quantifies differences between native lung and detergent-decellularized lung extracellular matrices. Acta Biomaterialia 2016, 46: 91-100. PMID: 27693690, PMCID: PMC5451113, DOI: 10.1016/j.actbio.2016.09.043.Peer-Reviewed Original ResearchConceptsExtracellular matrixLung extracellular matrixMatrix proteinsECM-associated proteinsCell-matrix interactionsProtein extraction methodsWhole organ regenerationRegenerative medicineOrganotypic cell culturesQuantitative proteomicsAcellular extracellular matrixECM proteinsOrgan regenerationCell adhesionProteomicsProtein analysisQuantitative biochemical dataProteinPotent substrateXenogeneic extracellular matrixTargeted proteomicsCell nuclear antigenBiochemical dataImportant glycoproteinCell cultures
2004
MMP‐2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP‐9 expression and activity
Esparza J, Kruse M, Lee J, Michaud M, Madri JA. MMP‐2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP‐9 expression and activity. The FASEB Journal 2004, 18: 1682-1691. PMID: 15522913, DOI: 10.1096/fj.04-2445com.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetAnimalsBasement MembraneBlood-Brain BarrierBrainCD3 ComplexCell MovementEncephalomyelitis, Autoimmune, ExperimentalEnzyme ActivationGene Expression Regulation, EnzymologicMatrix Metalloproteinase 14Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesMiceMice, KnockoutT-Lymphocyte SubsetsT-LymphocytesConceptsMMP-2 KO miceExperimental autoimmune encephalomyelitisMMP-9 expressionAutoimmune encephalomyelitisEarly onsetWT miceKO miceMMP-9Bone marrowSevere experimental autoimmune encephalomyelitisMMP-2 null miceSimilar early onsetWT bone marrowClinical disease scoresMMP-2-deficient miceKO bone marrowMatrix metalloproteinase-2MT1-MMP expressionEndothelial cell monolayersSevere diseaseDisease scoreMetalloproteinase-2Collagen type IVMMP-2Matrix metalloproteinase
1992
Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan.
Hayashi K, Madri J, Yurchenco P. Endothelial cells interact with the core protein of basement membrane perlecan through beta 1 and beta 3 integrins: an adhesion modulated by glycosaminoglycan. Journal Of Cell Biology 1992, 119: 945-959. PMID: 1385448, PMCID: PMC2289694, DOI: 10.1083/jcb.119.4.945.Peer-Reviewed Original ResearchCollagens facilitate epithelial migration in restitution of native guinea pig intestinal epithelium
Moore R, Madri J, Carlson S, Madara J. Collagens facilitate epithelial migration in restitution of native guinea pig intestinal epithelium. Gastroenterology 1992, 102: 119-130. PMID: 1727745, DOI: 10.1016/0016-5085(92)91791-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBasement MembraneBinding Sites, AntibodyCell MovementCollagenGuinea PigsIntestinal MucosaMaleMicrovilliWound Healing
1989
Dispase, a Neutral Protease From Bacillus Polymyxa, Is a Powerful Fibronectinase and Type IV Collagenase
Stenn K, Link R, Moellmann G, Madri J, Kuklinska E. Dispase, a Neutral Protease From Bacillus Polymyxa, Is a Powerful Fibronectinase and Type IV Collagenase. Journal Of Investigative Dermatology 1989, 93: 287-290. PMID: 2546994, DOI: 10.1111/1523-1747.ep12277593.Peer-Reviewed Original Research
1988
Reconstitution of Structure and Cell Function in Human Skin Grafts Derived from Cryopreserved Allogeneic Dermis and Autologous Cultured Keratinocytes
Langdon R, Cuono C, Birchall N, Madri J, Kuklinska E, McGuire J, Moellmann G. Reconstitution of Structure and Cell Function in Human Skin Grafts Derived from Cryopreserved Allogeneic Dermis and Autologous Cultured Keratinocytes. Journal Of Investigative Dermatology 1988, 91: 478-485. PMID: 2459265, DOI: 10.1111/1523-1747.ep12476623.Peer-Reviewed Original ResearchConceptsAllogeneic dermisAutologous cultured keratinocytesPresence of lymphocytesHuman skin graftsKeratinocyte culturesAutologous cultured epidermisBasement membrane zoneSkin graftsAutologous keratinocyte cultureDay 29Type IV collagenAutologous keratinocytesBurn woundsMembrane zoneGraftCadaveric skinCell functionCultured keratinocytesDermisHistologic qualityEpidermal cell culturesNormal patternAntibodiesDonor siteCryopreserved skin
1987
Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.
Tite J, Foellmer H, Madri J, Janeway C. Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen. The Journal Of Immunology 1987, 139: 2892-8. PMID: 3117879, DOI: 10.4049/jimmunol.139.9.2892.Peer-Reviewed Original ResearchConceptsT cell proliferative responsesCell proliferative responsesAntibody responseIr gene controlProliferative responseT cellsHigher antibody responseClass II MHCMHC congenic miceMajor histocompatibility complexImmunologic responsivenessResponder parentF1 miceII MHCDifferent MHC genotypesImmune responseType IV collagenCongenic miceMiceHistocompatibility complexIV collagenDifferential activationAntigenBasement membrane collagenMHC genotypeDependence on pH of polarized sorting of secreted proteins
Caplan M, Stow J, Newman A, Madri J, Anderson H, Farquhar M, Palade G, Jamieson J. Dependence on pH of polarized sorting of secreted proteins. Nature 1987, 329: 632-635. PMID: 2821405, DOI: 10.1038/329632a0.Peer-Reviewed Original ResearchConceptsSecretory proteinsMDCK cellsDifferent protein compositionsBasolateral cell surfacePolarized sortingMembrane proteinsBasolateral domainDefault pathwayPlasma membraneAcidic intracellular compartmentsIntracellular compartmentsProtein compositionMembrane componentsCell surfaceBasement membrane componentsProteinSecrete lamininDistinct setsRenal tubule cellsEpithelial cellsActive sortingBasolateral compartmentCellsSecretory productsSpecific regionsAortic endothelial cell proteoheparan sulfate. II. Modulation by extracellular matrix.
Keller R, Pratt B, Furthmayr H, Madri J. Aortic endothelial cell proteoheparan sulfate. II. Modulation by extracellular matrix. American Journal Of Pathology 1987, 128: 299-306. PMID: 2956886, PMCID: PMC1899612.Peer-Reviewed Original ResearchConceptsExtracellular matrixPlasma membraneHS IProteoheparan sulfate speciesSulfate biosynthesisEndothelial cellsHS IIIHS IICell polarityMajor cell typesExtracellular matrix componentsPolarized secretionBovine aortic endothelial cellsOrgan cultureTissue culture plasticSubcellular matrixBiosynthetic phenotypeMedium of cellsDifferentiated phenotypeCell typesMatrix moleculesVascular endothelial cellsAortic endothelial cellsProteoheparan sulfateSpeciesThe Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue
Buchanan M, Richardson M, Haas T, Hirsh J, Madri J. The Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue. Thrombosis And Haemostasis 1987, 58: 698-704. PMID: 3672420, DOI: 10.1055/s-0038-1645958.Peer-Reviewed Original ResearchConceptsEndothelial cellsPlatelet accumulationAir perfusionBalloon catheter injuryBasement membraneRabbit carotid arteryCatheter strippingCatheter injuryPerfusion injuryHuman endothelial cellsPlatelet reactivityInteraction of plateletsCarotid arteryElectron microscopic examinationVascular endotheliumTransmission electron microscopic examinationPlatelet adhesionCollagen type IInjuryOne hourConflicting resultsMicroscopic examinationSubendotheliumBasement membrane componentsVivo
1986
Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components.
Form D, Pratt B, Madri J. Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components. Laboratory Investigation 1986, 55: 521-30. PMID: 2430138.Peer-Reviewed Original ResearchA Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*
INGBER D, MADRI J, FOLKMAN J. A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*. Endocrinology 1986, 119: 1768-1775. PMID: 2428602, DOI: 10.1210/endo-119-4-1768.Peer-Reviewed Original ResearchRepopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro A novel system for type II pneumocyte culture
Lwebuga-Mukasa J, Ingbar D, Madri J. Repopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro A novel system for type II pneumocyte culture. Experimental Cell Research 1986, 162: 423-435. PMID: 3510880, DOI: 10.1016/0014-4827(86)90347-2.Peer-Reviewed Original ResearchBasement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.
Ingber DE, Madri JA, Jamieson JD. Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. American Journal Of Pathology 1986, 122: 129-39. PMID: 3942197, PMCID: PMC1888129.Peer-Reviewed Original ResearchConceptsDistinct membrane domainsEpithelial cell-cell interactionsCell shape changesCell-cell interactionsAcinar tumor cellsMembrane domainsTumor cellsBasement membranePolarized distributionSpatial organizersGolgi complexProtein synthesisIndividual cellsCell surfaceLipid dropletsIntracellular actinPancreatic acinar carcinomaJunctional complexesEpithelial tumor cellsCell contactCytoskeletal alterationsAmniotic basement membraneEpithelial orientationIntact basement membraneZymogen granules
1985
Neoplastic disorganization of pancreatic epithelial cell-cell relations. Role of basement membrane.
Ingber D, Madri J, Jamieson J. Neoplastic disorganization of pancreatic epithelial cell-cell relations. Role of basement membrane. American Journal Of Pathology 1985, 121: 248-60. PMID: 4061565, PMCID: PMC1888057.Peer-Reviewed Original Research
1984
An acellular human amnionic membrane model for in vitro culture of type ii pneumocytes: The role of the basement membrane in cell morphology and function
Lwebuga‐Mukasa J, Thulin G, Madri J, Barrett C, Warshaw J. An acellular human amnionic membrane model for in vitro culture of type ii pneumocytes: The role of the basement membrane in cell morphology and function. Journal Of Cellular Physiology 1984, 121: 215-225. PMID: 6548224, DOI: 10.1002/jcp.1041210127.Peer-Reviewed Original Research
1983
Capillary endothelial cell cultures: phenotypic modulation by matrix components.
Madri J, Williams S. Capillary endothelial cell cultures: phenotypic modulation by matrix components. Journal Of Cell Biology 1983, 97: 153-165. PMID: 6190818, PMCID: PMC2112496, DOI: 10.1083/jcb.97.1.153.Peer-Reviewed Original ResearchUltrastructural morphology and domain structure of a unique collagenous component of basement membranes.
Madri J, Foellmer H, Furthmayr H. Ultrastructural morphology and domain structure of a unique collagenous component of basement membranes. Biochemistry 1983, 22: 2797-804. PMID: 6409144, DOI: 10.1021/bi00281a005.Peer-Reviewed Original ResearchMethods in laboratory investigation. Monoclonal antibodies to type IV collagen: probes for the study of structure and function of basement membranes.
Foellmer H, Madri J, Furthmayr H. Methods in laboratory investigation. Monoclonal antibodies to type IV collagen: probes for the study of structure and function of basement membranes. Laboratory Investigation 1983, 48: 639-49. PMID: 6682465.Peer-Reviewed Original Research
1982
Rotary Shadowing of Connective Tissue Macromolecules
Furthmayr H, Madri J. Rotary Shadowing of Connective Tissue Macromolecules. Collagen And Related Research 1982, 2: 349-363. PMID: 7128049, DOI: 10.1016/s0174-173x(82)80025-3.Peer-Reviewed Original Research