2015
Cell–extracellular matrix interactions in oral tumorigenesis: Roles of podoplanin and CD44 and modulation of Hippo pathway
Tsuneki M, Madri J, Saku T. Cell–extracellular matrix interactions in oral tumorigenesis: Roles of podoplanin and CD44 and modulation of Hippo pathway. Journal Of Oral Biosciences 2015, 57: 45-53. DOI: 10.1016/j.job.2015.02.004.Peer-Reviewed Original ResearchCell-extracellular matrix interactionsHippo pathwayExtracellular matrixDynamic reciprocal interactionsMatrix interactionsCell surfaceHyaluronan-rich extracellular matrixMultifunctional transmembrane proteinBasolateral cell surfaceVascular endothelialEndothelial cell survivalAdhesion moleculesStromal cellsVascular endothelial cell survivalTransmembrane proteinMurine hemangioendothelioma cellsTumor cellsSquamous cell carcinoma cellsOral squamous cell carcinoma cellsCell survivalContact inhibitionVE-cadherinTissue architectureTumor survivalIntercellular spaces
1999
Extracellular Matrix-Driven Matrix Metalloproteinase Production in Endothelial Cells Implications for Angiogenesis
Haas T, Madri J. Extracellular Matrix-Driven Matrix Metalloproteinase Production in Endothelial Cells Implications for Angiogenesis. Trends In Cardiovascular Medicine 1999, 9: 70-77. PMID: 10578520, DOI: 10.1016/s1050-1738(99)00014-6.Peer-Reviewed Original ResearchConceptsInterstitial matrix moleculesCell-extracellular matrix interactionsBasement membrane matrixMatrix metalloproteinasesTranscriptional activationBlood vessel growthMatrix interactionsNew blood vessel growthMatrix moleculesCell surfaceExtracellular matrixMT1-MMPAdjacent cellsCell interactionsMatrix metalloproteinase productionCurrent understandingVessel growthParticular matrix metalloproteinasesEndothelial cell interactionsPotential roleAngiogenesisMetalloproteinase productionBasement membraneMMP-2Signaling
1998
Platelet endothelial cell adhesion molecule-1 expression modulates endothelial cell migration in vitro.
Kim C, Wang T, Madri J. Platelet endothelial cell adhesion molecule-1 expression modulates endothelial cell migration in vitro. Laboratory Investigation 1998, 78: 583-90. PMID: 9605183.Peer-Reviewed Original ResearchConceptsWild-type PECAM-1Endothelial cell migrationEndogenous PECAM-1Cell migrationCell-extracellular matrix interactionsMatrix interactionsTyrosine phosphorylation stateMurine conceptusCell-cell adhesionC-myc epitopeIntegrin-extracellular matrix interactionsCell-cell interactionsPECAM-1Endothelial cellsDynamic dephosphorylationCytoskeletal reorganizationEmbryonic vasculogenesisPhosphorylation stateMigratory stateMigration rateRetroviral transductionCultured endothelial cellsEndothelial cell adhesion molecule-1 expressionEndothelial cell adhesion molecule-1Y686Three-dimensional Type I Collagen Lattices Induce Coordinate Expression of Matrix Metalloproteinases MT1-MMP and MMP-2 in Microvascular Endothelial Cells*
Haas T, Davis S, Madri J. Three-dimensional Type I Collagen Lattices Induce Coordinate Expression of Matrix Metalloproteinases MT1-MMP and MMP-2 in Microvascular Endothelial Cells*. Journal Of Biological Chemistry 1998, 273: 3604-3610. PMID: 9452488, DOI: 10.1074/jbc.273.6.3604.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCollagenDrug CombinationsEndothelium, VascularEnzyme ActivationEnzyme InhibitorsGelatinasesLamininMatrix Metalloproteinase 2Matrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesNeovascularization, PhysiologicProtein ConformationProteoglycansRatsRats, Sprague-DawleyRNA, MessengerSignal TransductionTissue Inhibitor of Metalloproteinase-2ConceptsMT1-MMPTwo-dimensional cultureEndothelial cellsThree-dimensional collagen matrixEndothelial cell organizationEndothelial cell angiogenesisEndothelial cell migrationCell organizationCoordinate expressionPutative activatorMT1-MMP activationMMP-2Matrix metalloproteinasesCell migrationFunctional roleMatrix interactionsMatrix remodelingCollagen matrixCell angiogenesisEndothelial cell networksMMP-2 proteinProtein