2001
Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion*
Xie B, Zhao J, Kitagawa M, Durbin J, Madri J, Guan J, Fu X. Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion*. Journal Of Biological Chemistry 2001, 276: 19512-19523. PMID: 11278462, DOI: 10.1074/jbc.m009063200.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell AdhesionCell LineCell MovementDNA-Binding ProteinsDose-Response Relationship, DrugEnzyme ActivationFibroblastsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGene DeletionGlutathione TransferaseHumansIntegrinsMicroscopy, FluorescenceMutagenesis, Site-DirectedMutationPhosphorylationPlasmidsPrecipitin TestsProtein BindingProtein Structure, TertiaryProtein-Tyrosine KinasesSignal TransductionSTAT1 Transcription FactorSTAT3 Transcription FactorTime FactorsTrans-ActivatorsTransfectionConceptsFocal adhesion kinaseCell adhesionCell migrationFAK-deficient cellsIntegrin/focal adhesion kinaseC-terminal deletionsAdhesion kinaseTerminal domainFAK localizationTranscription pathwayFocal contactsSignal transducerSTAT1PathwayRecent studiesAdhesionMigrationCellsKinaseIntegrinsSTAT3DeletionActivatorFirst timeActivation
2000
Distinct roles for matrix metalloproteinase-2 and α4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis
Graesser D, Mahooti S, Madri J. Distinct roles for matrix metalloproteinase-2 and α4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis. Journal Of Neuroimmunology 2000, 109: 121-131. PMID: 10996214, DOI: 10.1016/s0165-5728(00)00275-7.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-2Auto-reactive T cellsExpression of alpha4T cellsMetalloproteinase-2Human multiple sclerosisExperimental autoimmune encephalomyelitisT cell extravasationMMP-2 inductionCentral nervous systemAutoimmune encephalomyelitisMultiple sclerosisAutoimmune diseasesBrain parenchymaNervous systemΑ4 integrinAlpha4 integrinsCell extravasationIndependent roleEAEAlpha4Basement membrane matrixInductionDistinct rolesIntegrins
1998
The synergistic activity of αvβ3 integrin and pdgf receptor increases cell migration
Woodard A, García-Cardeña G, Leong M, Madri J, Sessa W, Languino L. The synergistic activity of αvβ3 integrin and pdgf receptor increases cell migration. Journal Of Cell Science 1998, 111: 469-478. PMID: 9443896, DOI: 10.1242/jcs.111.4.469.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsAntigens, CDBecaplerminCell AdhesionCell DivisionCell MovementCells, CulturedEndothelium, VascularHumansIntegrin alphaVLamininMiceOligopeptidesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-sisRatsReceptor, Platelet-Derived Growth Factor betaReceptors, Platelet-Derived Growth FactorReceptors, VitronectinVitronectinConceptsMicrovascular endothelial cellsGrowth factor receptorGrowth factorEndothelial cellsFactor receptorCell migrationSynergistic activityPlatelet-derived growth factor receptorRat microvascular endothelial cellsAlphavbeta3 integrinGrowth factor-BBNIH 3T3 cellsTissue infiltrationFactor-BBNeovessel formationDifferent antibodiesPlateletsΑvβ3 integrinReceptorsAlphavbeta3Beta1 integrinCell's abilityIntegrinsCellsNovel pathway
1990
Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events.
Basson C, Knowles W, Bell L, Albelda S, Castronovo V, Liotta L, Madri J. Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. Journal Of Cell Biology 1990, 110: 789-801. PMID: 2407741, PMCID: PMC2116027, DOI: 10.1083/jcb.110.3.789.Peer-Reviewed Original ResearchConceptsMatrix-binding proteinsBeta 1 integrinLow-affinity integrinsRGD-dependent receptorExtracellular matrix-binding proteinsIntegrin beta 1Integrin subclassesBeta 1Beta 3Endothelial cell integrinsPeptide inhibitionBAECFibrinogenBAEC migrationCell integrinsLamininPerinuclear vesiclesIntegrinsAlpha subunitMatrix proteinsAdhesive eventsFibronectinPeptides