1997
Involvement of endothelial PECAM-1/CD31 in angiogenesis.
DeLisser H, Christofidou-Solomidou M, Strieter R, Burdick M, Robinson C, Wexler R, Kerr J, Garlanda C, Merwin J, Madri J, Albelda S. Involvement of endothelial PECAM-1/CD31 in angiogenesis. American Journal Of Pathology 1997, 151: 671-7. PMID: 9284815, PMCID: PMC1857836.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme InhibitorsAnimalsAntibodies, MonoclonalCells, CulturedCollagenCorneaDrug CombinationsEndotheliumFibroblast Growth Factor 2HumansLamininMiceMice, Inbred C57BLNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1ProteoglycansRatsRats, Sprague-DawleyTransforming Growth Factor betaConceptsCell-cell adhesion moleculesEndothelial cell-cell adhesion moleculesBasic fibroblast growth factorRat capillary endothelial cellsPECAM-1Adhesion moleculesHuman PECAM-1Murine PECAM-1Endothelial cellsFibroblast growth factorAdhesion receptorsProcess of angiogenesisPECAM-1/CD31Tube formationAdhesive interactionsVessel growthGrowth factorCapillary endothelial cellsPolyclonal antibodiesRat corneal neovascularizationAngiogenesisCorneal neovascularizationCellsMurine modelMonoclonal antibodies
1992
Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.
Merwin J, Lynch M, Madri J, Pastan I, Siegall C. Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells. Cancer Research 1992, 52: 4995-5001. PMID: 1381275.Peer-Reviewed Original ResearchMeSH KeywordsADP Ribose TransferasesAmino Acid SequenceAnimalsBacterial ToxinsCell MovementCell SurvivalCells, CulturedEndothelium, VascularExotoxinsFibroblast Growth Factor 1In Vitro TechniquesMolecular Sequence DataNeovascularization, PathologicRatsRats, Inbred StrainsReceptors, Cell SurfaceReceptors, Fibroblast Growth FactorRecombinant Fusion ProteinsVirulence FactorsConceptsGrowth factor beta 1Endothelial cellsChimeric toxinBeta 1Inhibitory effectDose-dependent toxic effectAnti-angiogenic agentsMicrovascular endothelial cellsAcidic fibroblast growth factorFibroblast growth factorSignificant inhibitory effectMicrovascular endotheliumAntiangiogenic effectsPseudomonas exotoxinTumor cell linesAntimigratory effectsGrowth factorAngiogenic responseProtein synthesisCell linesFGF receptorsToxic effectsCell deathEndotheliumCell viability analysis