2011
Brain regional angiogenic potential at the neurovascular unit during normal aging
Murugesan N, Demarest TG, Madri JA, Pachter JS. Brain regional angiogenic potential at the neurovascular unit during normal aging. Neurobiology Of Aging 2011, 33: 1004.e1-1004.e16. PMID: 22019053, PMCID: PMC3266473, DOI: 10.1016/j.neurobiolaging.2011.09.022.Peer-Reviewed Original ResearchConceptsNeurovascular unitPhysical exerciseNormal agingPolymerase chain reactionAngiogenesis-associated genesDiscrete brain regionsRegion-dependent wayReal-time polymerase chain reactionWeak angiogenic responseRegion-dependent mannerQuantitative real-time polymerase chain reactionCerebral angiogenesisAged brainAged miceLaser capture microdissectionTherapeutic benefitAge-related trendsBrain regionsAngiogenic capacityAngiogenic responseAngiogenic potentialChain reactionCapture microdissectionBrainHypoxia
2002
Disrupted synaptic development in the hypoxic newborn brain
Curristin SM, Cao A, Stewart WB, Zhang H, Madri JA, Morrow JS, Ment LR. Disrupted synaptic development in the hypoxic newborn brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 15729-15734. PMID: 12438650, PMCID: PMC137784, DOI: 10.1073/pnas.232568799.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisAtmosphere Exposure ChambersBrain Damage, ChronicCell DifferentiationCytoskeletonDisease Models, AnimalDNA, ComplementaryEndothelial Growth FactorsGene Expression ProfilingHypoxiaHypoxia-Inducible Factor 1, alpha SubunitHypoxia, BrainIntercellular Signaling Peptides and ProteinsLymphokinesMembrane ProteinsMiceMice, Inbred C57BLMicrotubulesNerve Tissue ProteinsOligodendrogliaOligonucleotide Array Sequence AnalysisStress, PhysiologicalSynapsesSynaptic TransmissionTranscription FactorsTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsPostnatal hypoxiaCerebral maturationGlial maturationNewborn brainSynaptic maturationPresynaptic functionPostsynaptic functionSublethal hypoxiaSynaptic developmentHealth crisisHypoxiaCognitive disabilitiesBrainMaturation programMaturationDysynchronyNeuropathologyInfantsNeurotransmissionCohortProtein assaysMiceHypoxic