2023
Screening, Diagnosis, and Staging of Non-Alcoholic Fatty Liver Disease (NAFLD): Application of Society Guidelines to Clinical Practice
Ilagan-Ying Y, Banini B, Do A, Lam R, Lim J. Screening, Diagnosis, and Staging of Non-Alcoholic Fatty Liver Disease (NAFLD): Application of Society Guidelines to Clinical Practice. Current Gastroenterology Reports 2023, 25: 213-224. PMID: 37768417, DOI: 10.1007/s11894-023-00883-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNon-alcoholic fatty liver diseaseNon-invasive testsFatty liver diseaseLiver diseaseCommon chronic liver diseaseNonalcoholic fatty liver diseaseCurrent expert guidelinesHigh-risk patientsChronic liver diseaseSteatotic liver diseaseClinical practice implicationsHepatic decompensationLiver biopsySociety guidelinesSpecialty referralsNovel therapiesExpert guidelinesLiver cancerDisease awarenessObesity epidemicSerum indicesClinical practiceScreening toolDiseaseDiagnosis
2022
The Independent Effect of Exercise on Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review
Chen G, Banini B, Do A, Lim J. The Independent Effect of Exercise on Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review. Clinical And Molecular Hepatology 2022, 29: s319-s332. PMID: 36517000, PMCID: PMC10029942, DOI: 10.3350/cmh.2022.0366.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseBiopsy-proven non-alcoholic fatty liver diseaseNon-invasive testsFatty liver diseaseHepatic steatosisLiver fibrosisLiver diseaseHistological endpointsIndependent effectsSystematic reviewNon-randomized interventional studyMagnetic resonance imaging-based techniquesAdditional large RCTsChronic liver diseaseSignificant histological improvementEffects of exerciseClinical outcome endpointsSystematic literature searchHistological improvementExercise interventionHepatocyte ballooningOriginal research studiesLarge RCTsOutcome endpointsInterventional study
2020
Abnormal Liver Tests in COVID‐19: A Retrospective Observational Cohort Study of 1,827 Patients in a Major U.S. Hospital Network
Hundt MA, Deng Y, Ciarleglio MM, Nathanson MH, Lim JK. Abnormal Liver Tests in COVID‐19: A Retrospective Observational Cohort Study of 1,827 Patients in a Major U.S. Hospital Network. Hepatology 2020, 72: 1169-1176. PMID: 32725890, PMCID: PMC9258788, DOI: 10.1002/hep.31487.Peer-Reviewed Original ResearchConceptsAbnormal liver testsLiver testsCohort studyClinical outcomesCOVID-19Yale New Haven Health SystemCoronavirus-19 disease (COVID-19) pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virusRetrospective observational cohort studyAcute respiratory distress syndromeRetrospective cohort studyLiver test abnormalitiesObservational cohort studySevere COVID-19Liver transaminase elevationsRespiratory distress syndromeBody mass indexPoor clinical outcomeCoronavirus 2 virusCOVID-19 treatmentNonpulmonary manifestationsPeak hospitalizationsICU admissionMultiorgan failureTransaminase elevationAGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19
Sultan S, Altayar O, Siddique SM, Davitkov P, Feuerstein JD, Lim JK, Falck-Ytter Y, El-Serag HB, . AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19. Gastroenterology 2020, 159: 320-334.e27. PMID: 32407808, PMCID: PMC7212965, DOI: 10.1053/j.gastro.2020.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingGastroenterologyGastrointestinal DiseasesGastrointestinal TractHumansLiverLiver DiseasesLiver Function TestsPandemicsPneumonia, ViralPractice Guidelines as TopicPrevalenceReferral and ConsultationSARS-CoV-2Societies, MedicalUnited StatesConceptsNausea/vomitingPooled prevalence estimatesAbdominal painLiver manifestationsGI symptomsLiver abnormalitiesCOVID-19Prevalence estimatesPractice statementsGI symptom questionnaireLiver enzyme abnormalitiesCertainty of evidencePrevalence of diarrheaCoronavirus disease 2019Best practice statementsSystematic literature searchStudy selection processFixed-effects modelNausea/Gastrointestinal symptomsLiver functionUnique patientsGRADE frameworkSubgroup analysisSymptom questionnaire
2016
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries
Kwo PY, Cohen SM, Lim JK. ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. The American Journal Of Gastroenterology 2016, 112: 18. PMID: 27995906, DOI: 10.1038/ajg.2016.517.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAlkaline PhosphataseAlpha 1-Antitrypsin DeficiencyAspartate AminotransferasesBilirubinBiopsyChemical and Drug Induced Liver InjuryCholestasisHemochromatosisHepatitis, AutoimmuneHepatitis, Viral, HumanHepatolenticular DegenerationHumansLiverLiver DiseasesLiver Diseases, AlcoholicNon-alcoholic Fatty Liver DiseaseConceptsAbnormal liver chemistriesLiver chemistriesAlkaline phosphatase levelsAlanine aminotransferaseHepatocellular diseaseAspartate aminotransferaseALT levelsDisproportionate elevationHepatocellular injuryLiver diseasePhosphatase levelsElevated total serum bilirubin (TSB) levelsIU/Conjugated bilirubinNonalcoholic fatty liver diseaseTotal serum bilirubin levelsAlpha-1 antitrypsin deficiencyElevated conjugated bilirubinSerum conjugated bilirubinTotal bilirubin elevationLiver-related mortalityElevated alanine aminotransferasePrimary sclerosing cholangitisViral hepatitis AAlcoholic liver disease