2023
Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Chen G, Banini B, Do A, Gunderson C, Zaman S, Lim J. Exercise Does Not Independently Improve Histological Outcomes in Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. Genes 2023, 14: 1811. PMID: 37761951, PMCID: PMC10531443, DOI: 10.3390/genes14091811.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseBiopsy-proven non-alcoholic fatty liver diseaseEffects of exerciseFatty liver diseaseHistological outcomesLiver histologyLiver diseaseClinical trialsHistological endpointsSystematic reviewSignificant histopathological improvementNAFLD activity scoreImpact of exerciseIndependent effectsRandom-effects modelSystematic literature searchHistopathological improvementExercise interventionActivity scoreClinical endpointsPooled estimatesMeta-AnalysisTotal participantsLiterature searchComparison group
2022
The Independent Effect of Exercise on Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review
Chen G, Banini B, Do A, Lim J. The Independent Effect of Exercise on Biopsy-Proven Non-Alcoholic Fatty Liver Disease: A Systematic Review. Clinical And Molecular Hepatology 2022, 29: s319-s332. PMID: 36517000, PMCID: PMC10029942, DOI: 10.3350/cmh.2022.0366.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseBiopsy-proven non-alcoholic fatty liver diseaseNon-invasive testsFatty liver diseaseHepatic steatosisLiver fibrosisLiver diseaseHistological endpointsIndependent effectsSystematic reviewNon-randomized interventional studyMagnetic resonance imaging-based techniquesAdditional large RCTsChronic liver diseaseSignificant histological improvementEffects of exerciseClinical outcome endpointsSystematic literature searchHistological improvementExercise interventionHepatocyte ballooningOriginal research studiesLarge RCTsOutcome endpointsInterventional study
2016
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries
Kwo PY, Cohen SM, Lim JK. ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries. The American Journal Of Gastroenterology 2016, 112: 18. PMID: 27995906, DOI: 10.1038/ajg.2016.517.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAlkaline PhosphataseAlpha 1-Antitrypsin DeficiencyAspartate AminotransferasesBilirubinBiopsyChemical and Drug Induced Liver InjuryCholestasisHemochromatosisHepatitis, AutoimmuneHepatitis, Viral, HumanHepatolenticular DegenerationHumansLiverLiver DiseasesLiver Diseases, AlcoholicNon-alcoholic Fatty Liver DiseaseConceptsAbnormal liver chemistriesLiver chemistriesAlkaline phosphatase levelsAlanine aminotransferaseHepatocellular diseaseAspartate aminotransferaseALT levelsDisproportionate elevationHepatocellular injuryLiver diseasePhosphatase levelsElevated total serum bilirubin (TSB) levelsIU/Conjugated bilirubinNonalcoholic fatty liver diseaseTotal serum bilirubin levelsAlpha-1 antitrypsin deficiencyElevated conjugated bilirubinSerum conjugated bilirubinTotal bilirubin elevationLiver-related mortalityElevated alanine aminotransferasePrimary sclerosing cholangitisViral hepatitis AAlcoholic liver disease