2022
A Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996–2020)
Smith A, Breazeale S, Goulet JL, Vlahov D, Justice AC, Womack JA. A Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996–2020). AIDS And Behavior 2022, 26: 2559-2573. PMID: 35107660, DOI: 10.1007/s10461-022-03591-y.Peer-Reviewed Original ResearchConceptsRisk factorsHIV-specific risk factorsInjection drug useHIV-1 RNACause of morbidityShare risk factorsPrevious suicide attemptsQuantitative study designHIV diagnosisPeer-reviewed journalsHIV infectionEligible studiesInclusion criteriaPsychiatric illnessElevated riskGeneral populationAlcohol misuseElectronic databasesDrug useSystematic reviewSuicide attemptsStudy designInitial searchSearch termsHIV
2020
Are we missing opioid-related deaths among people with HIV?
Becker WC, Gordon KS, Edelman EJ, Goulet JL, Kerns RD, Marshall BDL, Fiellin DA, Justice AC, Tate JP. Are we missing opioid-related deaths among people with HIV? Drug And Alcohol Dependence 2020, 212: 108003. PMID: 32417360, PMCID: PMC9580216, DOI: 10.1016/j.drugalcdep.2020.108003.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyOpioid useOverdose deathsLife-limiting conditionsUnnatural deathsGreater oddsAging Cohort StudyVACS IndexOpioid exposureCohort studyHIV infectionHIV statusRisk factorsOdds ratioDeath filesIndex causeHIVDisease severityDeathDecedentsIllicit useDifferential misclassificationOddsCauseOpioids
2019
Depression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study
So‐Armah K, Gupta S, Kundu S, Stewart J, Goulet J, Butt A, Sico J, Marconi, Crystal S, Rodriguez‐Barradas M, Budoff M, Gibert C, Chang C, Bedimo R, Freiberg. Depression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study. HIV Medicine 2019, 20: 317-329. PMID: 30924577, PMCID: PMC6459698, DOI: 10.1111/hiv.12726.Peer-Reviewed Original ResearchConceptsHIV infectionMajor depressive disorderHIV statusDepressive symptomsMedian followCause mortalityDepressive disorderMortality riskVeterans Aging Cohort Study (VACS) dataDeath rateMajor depressive disorder diagnosisFirst clinic visitCause mortality riskPHQ-9 scoresNinth Revision codesPatient Health QuestionnaireDepressive disorder diagnosisPHQ-9 dataCohort study dataContribution of depressionDepression definitionsClinic visitsCohort studyComorbid conditionsEligible participants
2016
Depression and HIV Infection Are Associated With Higher Risks of All-Cause Mortality in US Veterans: A Cohort Study
Gupta S, So-Armah K, Stewart J, Chang J, Goulet J, Freiberg M. Depression and HIV Infection Are Associated With Higher Risks of All-Cause Mortality in US Veterans: A Cohort Study. Open Forum Infectious Diseases 2016, 3: 2179. DOI: 10.1093/ofid/ofw172.1727.Peer-Reviewed Original ResearchHepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection
Tetrault JM, Tate JP, Edelman EJ, Gordon AJ, Re V, Lim JK, Rimland D, Goulet J, Crystal S, Gaither JR, Gibert CL, Rodriguez-Barradas MC, Fiellin LE, Bryant K, Justice AC, Fiellin DA. Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection. Journal Of Substance Use And Addiction Treatment 2016, 68: 62-67. PMID: 27431048, PMCID: PMC4976086, DOI: 10.1016/j.jsat.2016.06.002.Peer-Reviewed Original ResearchConceptsLiver enzyme elevationAlcohol use disorderUninfected patientsHepatotoxic medicationsHCV infectionUse disordersComposite endpointLiver injuryHIV/HCV co-infected patientsHCV co-infected patientsHIV/HCV statusPre-existing liver injuryCo-infected patientsCohort of HIVHepatitis C infectionHIV/HCVOpioid use disorderRisk of hepatotoxicityHCV statusHepatic safetyMedian ALTC infectionChart reviewEnzyme elevationHIV infection
2015
THE ASSOCIATION BETWEEN HIV STATUS AND HOMELESSNESS AMONG VETERANS IN CARE
Ghose T, Gordon A, Metraux S, Mattocks K, Goulet J, Rodriguez‐Barradas M, Day N, Blackstock O, Justice A. THE ASSOCIATION BETWEEN HIV STATUS AND HOMELESSNESS AMONG VETERANS IN CARE. Journal Of Community Psychology 2015, 43: 189-198. DOI: 10.1002/jcop.21673.Peer-Reviewed Original ResearchVeterans Affairs Health Care SystemVeterans Aging Cohort StudyHIV-negative veteransSubstance useAging Cohort StudyAfrican American substance usersGeneral veteran populationHIV-positive statusHazardous alcohol useHealth care systemCohort studyHIV infectionHIV-positiveHIV statusHigh riskVeteran populationWomen veteransHIVAlcohol useCare systemSubstance usersHomelessness riskLast monthVeteransHomelessness prevalence
2012
Receipt of Opioid Analgesics by HIV-Infected and Uninfected Patients
Edelman EJ, Gordon K, Becker WC, Goulet JL, Skanderson M, Gaither JR, Brennan Braden J, Gordon AJ, Kerns RD, Justice AC, Fiellin DA. Receipt of Opioid Analgesics by HIV-Infected and Uninfected Patients. Journal Of General Internal Medicine 2012, 28: 82-90. PMID: 22895747, PMCID: PMC3539026, DOI: 10.1007/s11606-012-2189-z.Peer-Reviewed Original ResearchConceptsLong-term opioidsHigh-dose opioidsUninfected patientsOpioid receiptHIV statusPain diagnosisHIV infectionVeterans Aging Cohort StudyVeterans Health Administration (VHA) careDaily morphine equivalent doseAcute pain diagnosisDays of opioidsMorphine equivalent doseAging Cohort StudyDesignCross-sectional analysisChronic pain diagnosesICD-9 codesVulnerable patient populationAverage daily doseMorphine equivalentsOpioid prescriptionsCohort studyDaily doseOpioid analgesicsPain managementHIV as an independent risk factor for incident lung cancer
Sigel K, Wisnivesky J, Gordon K, Dubrow R, Justice A, Brown ST, Goulet J, Butt AA, Crystal S, Rimland D, Rodriguez-Barradas M, Gibert C, Park LS, Crothers K. HIV as an independent risk factor for incident lung cancer. AIDS 2012, 26: 1017-1025. PMID: 22382152, PMCID: PMC3580210, DOI: 10.1097/qad.0b013e328352d1ad.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosIndependent risk factorUninfected patientsLung cancerSimilar HIVHIV infectionSurveillance biasRisk factorsIncidence rateVeterans Aging Cohort Study Virtual CohortVeterans Affairs Central Cancer RegistryChronic obstructive pulmonary diseaseIncident lung cancerObstructive pulmonary diseaseCentral Cancer RegistryLung cancer stageSimilar stage distributionRace/ethnicityExcess smokingMultivariable adjustmentAnalytic cohortPulmonary diseaseBacterial pneumoniaCancer RegistryPotential confounders
2011
Alcohol consumption and depressive symptoms over time: A longitudinal study of patients with and without HIV infection
Sullivan LE, Goulet JL, Justice AC, Fiellin DA. Alcohol consumption and depressive symptoms over time: A longitudinal study of patients with and without HIV infection. Drug And Alcohol Dependence 2011, 117: 158-163. PMID: 21345624, PMCID: PMC3113463, DOI: 10.1016/j.drugalcdep.2011.01.014.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyNon-hazardous drinkersDepressive symptomsAlcohol consumptionAlcohol abuseCohort studyHIV infectionBinge drinkersBinge drinkingNon-hazardous drinkingAging Cohort StudyPatient Health QuestionnaireUnhealthy alcohol consumptionCurrent alcohol useHIV statusHealth QuestionnaireTime-varying outcomeHazardous drinkersPatientsHIVHazardous drinkingAlcohol dependenceSymptomsAlcohol useSimilar alterationsIncreased Risk of Fragility Fractures among HIV Infected Compared to Uninfected Male Veterans
Womack JA, Goulet JL, Gibert C, Brandt C, Chang CC, Gulanski B, Fraenkel L, Mattocks K, Rimland D, Rodriguez-Barradas MC, Tate J, Yin MT, Justice AC, . Increased Risk of Fragility Fractures among HIV Infected Compared to Uninfected Male Veterans. PLOS ONE 2011, 6: e17217. PMID: 21359191, PMCID: PMC3040233, DOI: 10.1371/journal.pone.0017217.Peer-Reviewed Original ResearchConceptsBody mass indexHIV infectionUninfected menFragility fracturesFracture riskRisk factorsMale veteransVeterans Aging Cohort Study Virtual CohortCurrent protease inhibitor useFragility fracture risk factorsMedian body mass indexHIV-specific factorsAdjusted hazard ratioProtease inhibitor useFracture risk factorsFragility fracture riskIncident hipHazard ratioInhibitor useUnadjusted riskHIV statusMass indexAlcohol abuseHIVUpper armAssociation of Age and Comorbidity with Physical Function in HIV-Infected and Uninfected Patients: Results from the Veterans Aging Cohort Study
Oursler KK, Goulet JL, Crystal S, Justice AC, Crothers K, Butt AA, Rodriguez-Barradas MC, Favors K, Leaf D, Katzel LI, Sorkin JD. Association of Age and Comorbidity with Physical Function in HIV-Infected and Uninfected Patients: Results from the Veterans Aging Cohort Study. AIDS Patient Care And STDs 2011, 25: 13-20. PMID: 21214375, PMCID: PMC3030913, DOI: 10.1089/apc.2010.0242.Peer-Reviewed Original ResearchConceptsChronic pulmonary diseaseAge-associated comorbiditiesPhysical functionUninfected patientsPulmonary diseaseUninfected subjectsSelf-reported physical functionVeterans Aging Cohort StudyAging of HIVHIV care guidelinesVeterans Aging CohortHIV clinical careAging Cohort StudyAssociation of ageCross-sectional analysisOlder HIVCohort studyHIV infectionHIV statusCare guidelinesPoor functionCardiovascular diseaseClinical carePhysical subscaleHIV
2010
HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era
Crothers K, Huang L, Goulet JL, Goetz MB, Brown ST, Rodriguez-Barradas MC, Oursler KK, Rimland D, Gibert CL, Butt AA, Justice AC. HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era. American Journal Of Respiratory And Critical Care Medicine 2010, 183: 388-395. PMID: 20851926, PMCID: PMC3266024, DOI: 10.1164/rccm.201006-0836oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCombination antiretroviral therapy eraAntiretroviral therapy eraPulmonary diseaseTherapy eraPulmonary infectionHIV infectionVeterans Aging Cohort Study Virtual CohortIncident chronic obstructive pulmonary diseaseLower HIV RNA levelsVirtual cohortVeterans Affairs Healthcare SystemAssociation of HIVMost pulmonary diseasesHIV RNA levelsRates of asthmaIncidence rate ratiosSelf-reported smokingLarge Health SurveyPulmonary hypertensionUninfected patientsComorbid diseasesOpportunistic pneumoniaBacterial pneumonia
2009
The Association Between the Receipt of Lipid Lowering Therapy and HIV Status Among Veterans Who Met NCEP/ATP III Criteria for the Receipt of Lipid Lowering Medication
Freiberg MS, Leaf DA, Goulet JL, Goetz MB, Oursler KK, Gibert CL, Rodriguez-Barradas MC, Butt AA, Justice AC. The Association Between the Receipt of Lipid Lowering Therapy and HIV Status Among Veterans Who Met NCEP/ATP III Criteria for the Receipt of Lipid Lowering Medication. Journal Of General Internal Medicine 2009, 24: 334-340. PMID: 19127386, PMCID: PMC2642578, DOI: 10.1007/s11606-008-0891-7.Peer-Reviewed Original ResearchConceptsNCEP/ATP III criteriaATP III criteriaHIV viral loadViral loadAdult Treatment Panel guidelinesHigher HIV viral loadFive-site studyLipid lowering medicationsVeterans Aging CohortHIV infection statusLipid-Lowering TherapyProspective observational cohortCross-sectional analysisHIV-HCVLowering therapiesModifiable mediatorsObservational cohortResultsThe prevalenceHIV infectionHIV statusPharmacy dataCardiovascular diseasePanel guidelinesMAIN OUTCOMELow prevalence
2008
Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study
Rodriguez-Barradas MC, Goulet J, Brown S, Goetz MB, Rimland D, Simberkoff MS, Crothers K, Justice AC. Impact of Pneumococcal Vaccination on the Incidence of Pneumonia by HIV Infection Status among Patients Enrolled in the Veterans Aging Cohort 5-Site Study. Clinical Infectious Diseases 2008, 46: 1093-1100. PMID: 18444830, PMCID: PMC3115628, DOI: 10.1086/529201.Peer-Reviewed Original ResearchConceptsPneumococcal polysaccharide vaccineVeterans Aging CohortPPV vaccinationIncidence of pneumoniaAging CohortCox proportional hazards regression methodsLow CD4 cell countsProportional hazards regression methodsCD4 cell countHIV infection statusRisk of pneumoniaLower hemoglobin levelsBenefits of vaccinationHuman immunodeficiency virusOngoing prospective studyElectronic medical recordsPneumococcal vaccinationPneumonia eventsUnvaccinated patientsCurrent smokingPneumococcal diseasePolysaccharide vaccineVaccination statusHIV infectionRetrospective review
2007
Do Patterns of Comorbidity Vary by HIV Status, Age, and HIV Severity?
Goulet JL, Fultz SL, Rimland D, Butt A, Gibert C, Rodriguez-Barradas M, Bryant K, Justice AC. Do Patterns of Comorbidity Vary by HIV Status, Age, and HIV Severity? Clinical Infectious Diseases 2007, 45: 1593-1601. PMID: 18190322, PMCID: PMC3687553, DOI: 10.1086/523577.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCD4 cell countPatterns of comorbidityHIV infectionHIV statusCell countHIV severityOlder human immunodeficiency virusPrimary care guidelinesClinical Modification codesCells/Pulmonary diseaseComorbid conditionsMultivariable analysisViral loadCare guidelinesImmunodeficiency virusComorbiditiesInternational ClassificationMultimorbidityInfectionPresence of conditionsVeteransAgeDisease
2006
Veterans Aging Cohort Study (VACS)
Justice AC, Dombrowski E, Conigliaro J, Fultz SL, Gibson D, Madenwald T, Goulet J, Simberkoff M, Butt AA, Rimland D, Rodriguez-Barradas MC, Gibert CL, Oursler KA, Brown S, Leaf DA, Goetz MB, Bryant K. Veterans Aging Cohort Study (VACS). Medical Care 2006, 44: s13-s24. PMID: 16849964, PMCID: PMC3049942, DOI: 10.1097/01.mlr.0000223741.02074.66.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHuman immunodeficiency virusAging Cohort StudyCohort studyHIV infectionGeneral medical clinicMultisite observational studyElectronic medical record systemRace/ethnicityUninfected patientsBaseline characteristicsMedical record systemTarget enrollmentImmunodeficiency virusObservational studyNational VAMedical clinicsInfectious diseasesDisease controlTelephone interviewsStudy designAlcohol useEnrollment targetsCareVeterans
2000
Psychiatric comorbidity and the long-term care of people with aids
Goulet J, Molde S, Constantino S, Gaughan D, Selwyn P. Psychiatric comorbidity and the long-term care of people with aids. Journal Of Urban Health 2000, 77: 213-221. PMID: 10856002, PMCID: PMC3456122, DOI: 10.1007/bf02390532.Peer-Reviewed Original ResearchConceptsPsychiatric disordersLong-term careHuman immunodeficiency virus (HIV) disease severityBaseline clinical evaluationFurther therapeutic improvementsResultsForty-five patientsLong-term care facilitiesSystematic chart reviewComorbid psychiatric disordersNumber of patientsHealth service plannersChronic psychiatric disorderPersistent psychiatric disordersCost of careVirus disease severityHIV careChart reviewClinical characteristicsHIV diseaseDisease courseHIV infectionImmunodeficiency syndromePsychiatric comorbidityAdmission characteristicsClinical evaluation