2020
Nonsteroidal Anti-inflammatory Drugs vs Cognitive Behavioral Therapy for Arthritis Pain
Fraenkel L, Buta E, Suter L, Dubreuil M, Levy C, Najem C, Brennan M, Corn B, Kerns R, Goulet J. Nonsteroidal Anti-inflammatory Drugs vs Cognitive Behavioral Therapy for Arthritis Pain. JAMA Internal Medicine 2020, 180: 1194-1202. PMID: 32702101, PMCID: PMC7372512, DOI: 10.1001/jamainternmed.2020.2821.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsWOMAC pain scorePain scoresAnti-inflammatory drugsGlobal ImpressionKnee osteoarthritisMeloxicam groupMcMaster Universities Osteoarthritis Index (WOMAC) pain scoreCurrent nonsteroidal anti-inflammatory drugsLong-term clinical benefitMean differencePain score differenceParticipant global impressionWOMAC disability scoresKnee osteoarthritis painLower extremity disabilityPrimary outcome measureSignificant differencesCognitive behavioral therapy programCognitive behavioral therapyBehavioral therapy programBaseline painOsteoarthritis painTreat basisDisability scores
2017
Discontinuing a non-steroidal anti-inflammatory drug (NSAID) in patients with knee osteoarthritis: Design and protocol of a placebo-controlled, noninferiority, randomized withdrawal trial
Goulet JL, Buta E, Brennan M, Heapy A, Fraenkel L. Discontinuing a non-steroidal anti-inflammatory drug (NSAID) in patients with knee osteoarthritis: Design and protocol of a placebo-controlled, noninferiority, randomized withdrawal trial. Contemporary Clinical Trials 2017, 65: 1-7. PMID: 29198731, DOI: 10.1016/j.cct.2017.11.020.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAge FactorsAgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalDisability EvaluationDouble-Blind MethodEquivalence Trials as TopicFemaleHumansMaleMeloxicamMiddle AgedOsteoarthritis, KneePain MeasurementPatient Education as TopicResearch DesignSeverity of Illness IndexSex FactorsSocial SupportYoung AdultConceptsNon-steroidal anti-inflammatory drugsUse of NSAIDsOA knee painKnee painKnee osteoarthritisAnti-inflammatory drugsWithdrawal trialCurrent non-steroidal anti-inflammatory drugsKnee OA painPainful knee osteoarthritisClasses of medicationsLower extremity disabilityTwo-week runFirst clinical trialVA healthcare systemOA painEligible subjectsSecondary outcomesPrimary outcomeGlobal ImpressionNSAID toxicityNoninferiority marginClinical trialsExtremity disabilityCommon cause