2019
Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior.
Deak J, Gizer I, Otto J, Bizon C, Wilhelmsen K. Effects of Common and Rare Chromosome 4 GABAergic Gene Variation on Alcohol Use and Antisocial Behavior. Journal Of Studies On Alcohol And Drugs 2019, 80: 585-593. PMID: 31790348, PMCID: PMC6900988, DOI: 10.15288/jsad.2019.80.585.Peer-Reviewed Original ResearchConceptsVariant associationsCommon variant associationsRare variant association testsRare variant signalsGene-based analysisRare variant associationsMolecular genetic studiesSingle variant analysisIntergenic regionRare variationAlcohol use disorderTop associationsSequencing dataVariant contributionsGenetic studiesAlcoholism (COGA) sampleGenetic sequencing dataReceptor geneUse disordersVariant signalsGene variationTypes of variationConfer riskStrong associationSignificant association
2017
A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use
Otto J, Gizer I, Deak J, Fleming K, Bartholow B. A cis‐eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcohol Clinical And Experimental Research 2017, 41: 929-938. PMID: 28273335, PMCID: PMC5404990, DOI: 10.1111/acer.13369.Peer-Reviewed Original ResearchConceptsBiphasic Alcohol Effects ScaleAlcohol useAlcohol use phenotypesSubjective responsesΜ-opioid receptor geneConsistent significant associationsEffects of alcoholHeroin dependenceSignificant associationPast monthEffects ScaleFunctional polymorphismsAlcohol challengeObserved associationsLow levels