2022
Spatial profiling of chromatin accessibility in mouse and human tissues
Deng Y, Bartosovic M, Ma S, Zhang D, Kukanja P, Xiao Y, Su G, Liu Y, Qin X, Rosoklija GB, Dwork AJ, Mann JJ, Xu ML, Halene S, Craft JE, Leong KW, Boldrini M, Castelo-Branco G, Fan R. Spatial profiling of chromatin accessibility in mouse and human tissues. Nature 2022, 609: 375-383. PMID: 35978191, PMCID: PMC9452302, DOI: 10.1038/s41586-022-05094-1.Peer-Reviewed Original ResearchConceptsChromatin accessibilityATAC-seqSpecific epigenetic landscapesChromatin accessibility profilingCell fate decisionsEpigenetic informationEpigenetic landscapeGenome scaleFate decisionsAccessible genomeCell identityEpigenetic underpinningsNext-generation sequencingGene regulatorsCell statesMouse embryosSpatial biologySpatial transcriptomicsCell typesCellular levelImmune cell typesDistinct organizationHuman tissuesProfilingSpatial profiling
1987
Patterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus
Hardin J, Craft J. Patterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus. Rheumatic Disease Clinics Of North America 1987, 13: 37-46. PMID: 3306823, DOI: 10.1016/s0889-857x(21)00820-6.Peer-Reviewed Original ResearchConceptsAnti-Ro antibodiesAnti-DNA antibodiesAnti-Sm antibodiesAutoimmune responseAnti-U1 RNP antibodiesB lymphocyte hyperactivityPatterns of autoimmunitySystemic lupus erythematosusRo particleAnti-U1 RNPAnti-La antibodiesB lymphocyte clonesLupus erythematosusRNP antibodiesImmune regulationImmune responseH2B antibodiesAntibodiesAnti-histone H1Different antibodiesNucleoproteinResponseGeneral defectErythematosusAutoantibodies