Clinical manifestations of lyme disease
Steere A, Bartenhagen N, Craft J, Hutchinson G, Newman J, Pachner A, Rahn D, Sigal L, Taylor E, Malawista S. Clinical manifestations of lyme disease. International Journal Of Medical Microbiology 1986, 263: 201-205. PMID: 3554839, DOI: 10.1016/s0176-6724(86)80123-7.Peer-Reviewed Original ResearchConceptsMigratory musculoskeletal painErythema chronicum migransLyme diseaseMusculoskeletal painClinical manifestationsUnique skin lesionNon-productive coughDifferent clinical manifestationsFrank arthritisMononeuritis multiplexAcute myopericarditisCardiac involvementCranial neuritisSkin involvementUrticarial rashSore throatNeurologic abnormalitiesPeriorbital edemaAV blockDisease onsetSecondary lesionsSkin lesionsPatientsDiseaseLesionsAntigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.
Craft JE, Fischer DK, Shimamoto GT, Steere AC. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. Journal Of Clinical Investigation 1986, 78: 934-939. PMID: 3531237, PMCID: PMC423723, DOI: 10.1172/jci112683.Peer-Reviewed Original ResearchConceptsIgG responsesIgM responseEarly diseaseLyme diseaseImmunoglobulin M responseImmunoglobulin G responseBorrelia burgdorferiSpirochetal antigensG responsesIgG antibodiesProlonged illnessPatientsM responseIllnessDiseaseAntigenB. burgdorferiMonthsLimited responseIgMBurgdorferiSuch responsesResponseArthritisYears