Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation.
Fatenejad S, Peng SL, Disorbo O, Craft J. Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation. The Journal Of Immunology 1998, 161: 6427-32. PMID: 9834135, DOI: 10.4049/jimmunol.161.11.6427.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisAutoimmune DiseasesCell LineClonal DeletionColumbidaeCytochrome c GroupDown-RegulationFas ReceptorGene Rearrangement, alpha-Chain T-Cell Antigen ReceptorImmune ToleranceLupus NephritisLymphocyte ActivationMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicMolecular Sequence DataMutationPeptidesReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte SubsetsThymus GlandConceptsMRL/MpJ miceLupus-prone miceT cell toleranceCentral T cell toleranceT cellsLpr mutationCell toleranceSystemic autoimmune diseaseT cell autoreactivityAutoreactive T cellsB cell helpIntrathymic negative selectionMHC class IIMRL/MpJPeripheral control mechanismsAutoimmune backgroundThymic deletionIntrathymic deletionAutoimmune diseasesNonautoimmune miceCell helpTCR transgeneNonautoimmune strainsPeptide AgImmature CD4