2022
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection
Zander R, Kasmani MY, Chen Y, Topchyan P, Shen J, Zheng S, Burns R, Ingram J, Cui C, Joshi N, Craft J, Zajac A, Cui W. Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection. Immunity 2022, 55: 475-493.e5. PMID: 35216666, PMCID: PMC8916994, DOI: 10.1016/j.immuni.2022.01.018.Peer-Reviewed Original ResearchConceptsChronic viral infectionsIL-21Cell responsesViral infectionMixed bone marrow chimera experimentsBone marrow chimera experimentsMemory-like subsetTfh cell responsesCell-mediated immunityTfh cellsEffector CD8LCMV infectionHelper subsetsInterleukin-21Th1 cellsViral controlCD8Chimera experimentsCD4InfectionCell differentiationCellsSubsetResponseDistinct populations
2016
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 2016, 352: 99-103. PMID: 27034374, PMCID: PMC4935984, DOI: 10.1126/science.aaf1358.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsAsthmaBlood ProteinsDendritic CellsDisease Models, AnimalGene Knockout TechniquesHost-Parasite InteractionsHumansImmunity, InnateInterleukin-4MiceMice, Inbred C57BLMice, KnockoutNippostrongylusProtein SPyroglyphidaeReceptor Protein-Tyrosine KinasesStrongylida InfectionsT-LymphocytesConceptsType 2 immunityType 2 responsesType 2 cytokinesHuman dendritic cellsInnate immune cellsDendritic cellsAllergic diseasesImmune cellsT cellsAdaptive immunityInterleukin-4Host responseFunctional neutralizationGenetic ablationReceptor tyrosine kinasesImmunityProtective functionTyro3Tyrosine kinaseNegative regulatorPROS1CellsResponseCytokinesDisease
2000
γδ T cells in autoimmunity
Yin Z, Craft J. γδ T cells in autoimmunity. Seminars In Immunopathology 2000, 22: 311-320. PMID: 11116960, DOI: 10.1007/s002810000048.Peer-Reviewed Original Research
1994
Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.
Fatenejad S, Brooks W, Schwartz A, Craft J. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target. The Journal Of Immunology 1994, 152: 5523-31. PMID: 7514640, DOI: 10.4049/jimmunol.152.11.5523.Peer-Reviewed Original ResearchConceptsMRL/lpr miceMRL/Mp-lpr/lpr miceLpr miceAnti-Sm AbsHuman SLEAnti-Sm responseRibonucleoprotein antibodiesNormal miceImmune responseMiceSLEEarly AbsSimilar epitopesD proteinsSerumHuman serumEpitopesU1 snRNP particleFrequent responsePrevious findingsAbResponseSnRNP particlesHumansPrevious observations
1987
Patterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus
Hardin J, Craft J. Patterns of Autoimmunity to Nucleoproteins in Patients with Systemic Lupus Erythematosus. Rheumatic Disease Clinics Of North America 1987, 13: 37-46. PMID: 3306823, DOI: 10.1016/s0889-857x(21)00820-6.Peer-Reviewed Original ResearchConceptsAnti-Ro antibodiesAnti-DNA antibodiesAnti-Sm antibodiesAutoimmune responseAnti-U1 RNP antibodiesB lymphocyte hyperactivityPatterns of autoimmunitySystemic lupus erythematosusRo particleAnti-U1 RNPAnti-La antibodiesB lymphocyte clonesLupus erythematosusRNP antibodiesImmune regulationImmune responseH2B antibodiesAntibodiesAnti-histone H1Different antibodiesNucleoproteinResponseGeneral defectErythematosusAutoantibodies
1986
Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.
Craft JE, Fischer DK, Shimamoto GT, Steere AC. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. Journal Of Clinical Investigation 1986, 78: 934-939. PMID: 3531237, PMCID: PMC423723, DOI: 10.1172/jci112683.Peer-Reviewed Original ResearchConceptsIgG responsesIgM responseEarly diseaseLyme diseaseImmunoglobulin M responseImmunoglobulin G responseBorrelia burgdorferiSpirochetal antigensG responsesIgG antibodiesProlonged illnessPatientsM responseIllnessDiseaseAntigenB. burgdorferiMonthsLimited responseIgMBurgdorferiSuch responsesResponseArthritisYears