Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade
Gonzalez-Quintial R, Lawson BR, Scatizzi JC, Craft J, Kono DH, Baccala R, Theofilopoulos AN. Systemic Autoimmunity and Lymphoproliferation Are Associated with Excess IL-7 and Inhibited by IL-7Rα Blockade. PLOS ONE 2011, 6: e27528. PMID: 22102903, PMCID: PMC3213145, DOI: 10.1371/journal.pone.0027528.Peer-Reviewed Original ResearchConceptsT cellsIL-7Systemic autoimmunityIL-7R blockadeIL-7Rα blockadeAutoreactive T cellsMemory T cellsAdvanced disease stageProgression of autoimmunityFibroblastic reticular cellsNovel therapeutic approachesT cell activationAutoimmune manifestationsAutoimmune syndromeCommensal antigensDisease stageIL-7RαTherapeutic approachesLymphocyte homeostasisCell activationReticular cellsAutoimmunityMarked accumulationLupusBlockade