Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens
Vratsanos G, Jung S, Park Y, Craft J. Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens. Journal Of Experimental Medicine 2001, 193: 329-338. PMID: 11157053, PMCID: PMC2195926, DOI: 10.1084/jem.193.3.329.Peer-Reviewed Original ResearchConceptsT cell receptorLupus-prone miceT cellsT cell activationPigeon cytochrome cAlpha/beta T cellsCell activationTransgenic T cell receptorBeta T cellsAntigen-presenting cellsCBA/CaJT cell receptor engagementLow affinityBeta-chain geneMRL/Cell receptor engagementPolyclonal activationSpontaneous lupusAmino acids 88Cognate antigenCell receptorAntigenPeptide ligandsReceptor engagementLupus