2017
Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus.
Choi JY, Seth A, Kashgarian M, Terrillon S, Fung E, Huang L, Wang LC, Craft J. Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus. The Journal Of Immunology 2017, 198: 2578-2588. PMID: 28219887, PMCID: PMC5360548, DOI: 10.4049/jimmunol.1601687.Peer-Reviewed Original ResearchConceptsIL-21Systemic lupus erythematosusMurine lupusTfh cellsLupus erythematosusDisease ameliorationGerminal center B cell responsesTfh-B cell interactionsGC responseFollicular Th cellsIL-21 blockadeLupus-prone B6Progression of glomerulonephritisCell-derived cytokinesB cell responsesMemory B cell developmentPotential therapeutic strategyB cell proliferationB cell maturationGC B cellsOverall survivalOrgan injuryAutoantibody productionLatter cytokineTh cells
2002
The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice
FUJII T, OKADA M, MIMORI T, CRAFT J. The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Faslpr mice. Clinical & Experimental Immunology 2002, 130: 224-232. PMID: 12390309, PMCID: PMC1906522, DOI: 10.1046/j.1365-2249.2002.01982.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearB-LymphocytesCD40 LigandCell LineCells, CulturedCoculture TechniquesLupus Erythematosus, SystemicLymphocyte ActivationLymphocyte CooperationMembrane ProteinsMiceMice, Inbred MRL lprMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Tumor Necrosis FactorRibonucleoproteins, Small NuclearTh1 CellsTumor Necrosis Factor-alphaConceptsB cell proliferationTh1 linesTNF-alphaB cellsAntibody productionCell proliferationContact-dependent helpMRL/MpB cell helpMHC class IITh1 cell linesB cell activationCD40-CD154Autoantibody productionTh1 cellsCell helpMRL miceMTNF-alphaProliferative responseHigh titresCell activationTNF-R2Class IITransmembrane formMonoclonal antibodies