TMIC-16. TUMOR-INFILTRATING MYELOID CELLS MEDIATE ADAPTIVE IMMUNE RESISTANCE IN GLIOBLASTOMA
Antonios J, Soto H, Everson R, Orpilla J, Shin N, Moughon D, Sedighim S, Treger J, Odesa S, Tucker A, Yong W, Cloughesy T, Prins R, Liau L. TMIC-16. TUMOR-INFILTRATING MYELOID CELLS MEDIATE ADAPTIVE IMMUNE RESISTANCE IN GLIOBLASTOMA. Neuro-Oncology 2016, 18: vi203-vi203. DOI: 10.1093/neuonc/now212.856.Peer-Reviewed Original ResearchPD-1 mAbPD-1/PD-L1PD-1Immune responseDendritic cellsMAb blockadeColony stimulating factor 1 receptor inhibitorTumor lysate-pulsed dendritic cellsProgrammed death-1/ligand-1Cytolysis of tumor cellsMurine in vivo studiesDC vaccine treatmentAdaptive immune resistanceExpressed PD-L1Cell populationsVaccine treatmentTreatment to miceDominant mediatorIn vitro cytotoxicity assayTIL populationsPD-L1TIL infiltrationGL261 tumorsReceptor inhibitorsTumor microenvironment