2024
Observational study protocol for an arrhythmia notification feature
Kumar S, Weinstein J, Melchinger H, Smith A, Capodilupo E, Akar J, Garg K, O’Connor K, Staunton M, Martin M, Akhlaghi N, Edeh O, Perez S, Lee V, Lee K, Wilson F. Observational study protocol for an arrhythmia notification feature. BMJ Open 2024, 14: e075110. PMID: 38830741, PMCID: PMC11149124, DOI: 10.1136/bmjopen-2023-075110.Peer-Reviewed Original ResearchConceptsAtrial fibrillationInstitution of appropriate treatmentGold standardClinical research journalsAssessment of risk factorsObservational study protocolRecruited participantsEthics BoardGeneral populationDiagnosed AFHealthy controlsPrimary outcomeAppropriate treatmentStudy protocolRisk factorsConsent documentsWHOOP strapParticipantsArrhythmiasDetect AFWearable technology
2020
Enhanced electrocardiographic monitoring of patients with Coronavirus Disease 2019
Jain S, Workman V, Ganeshan R, Obasare ER, Burr A, DeBiasi RM, Freeman JV, Akar J, Lampert R, Rosenfeld LE. Enhanced electrocardiographic monitoring of patients with Coronavirus Disease 2019. Heart Rhythm 2020, 17: 1417-1422. PMID: 32387247, PMCID: PMC7200355, DOI: 10.1016/j.hrthm.2020.04.047.Peer-Reviewed Original ResearchConceptsQT prolongationCoronavirus disease 2019Electrocardiographic monitoringDisease 2019Pandemic coronavirus disease 2019QT-prolonging medicationsModifiable risk factorsIntensive care unitQT-prolonging drugsOngoing pandemic coronavirus disease 2019Assessment-Recommendation (SBAR) toolCOVID-19Electrophysiology serviceElectrolyte abnormalitiesCare unitUnique patientsPrimary teamRisk factorsPatientsPatient safetyECG monitoringProlongationRelevant interventionsTorsadesPointes3-Dimensional Transseptal Puncture Based on Electrographic Characteristics of Fossa Ovalis A Fluoroscopy-Free and Echocardiography-Free Method
Yu R, Liu N, Lu J, Zhao X, Hu Y, Zhang J, Xu F, Tang R, Bai R, Akar JG, Dong J, Ma C. 3-Dimensional Transseptal Puncture Based on Electrographic Characteristics of Fossa Ovalis A Fluoroscopy-Free and Echocardiography-Free Method. JACC Cardiovascular Interventions 2020, 13: 1223-1232. PMID: 32438994, DOI: 10.1016/j.jcin.2020.03.015.Peer-Reviewed Original ResearchConceptsAtrial fibrillation ablationFossa ovalisElectrographic characteristicsFibrillation ablationElectroanatomic mappingTransseptal puncture techniqueMajor complicationsRight atriumAncillary imagingAtrial potentialsCatheter connectionsTransseptal needleTransseptal punctureElectrogram voltageIntracardiac echocardiographyElectroanatomic mapsPuncture techniqueEchocardiographyFos mappingPatientsFluoroscopyAblationComplicationsPrecise localizationAtrium
2017
A method for quantifying recurrent patterns of local wavefront direction during atrial fibrillation
Hummel JP, Baher A, Buck B, Fanarjian M, Webber CL, Akar JG. A method for quantifying recurrent patterns of local wavefront direction during atrial fibrillation. Computers In Biology And Medicine 2017, 89: 497-504. PMID: 28889077, DOI: 10.1016/j.compbiomed.2017.08.027.Peer-Reviewed Original Research
2009
Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study
Ip J, Waldo AL, Lip GY, Rothwell PM, Martin DT, Bersohn MM, Choucair WK, Akar JG, Wathen MS, Rohani P, Halperin JL, Investigators F. Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: Rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study. American Heart Journal 2009, 158: 364-370.e1. PMID: 19699858, DOI: 10.1016/j.ahj.2009.07.002.Peer-Reviewed Original ResearchConceptsAtrial high-rate episodesRisk of strokeAnticoagulant therapyAtrial fibrillationAtrial flutterCardiac resynchronization therapy-defibrillator deviceConventional clinical managementRemote rhythm monitoringStudies of anticoagulationRate of strokeOral anticoagulant therapyHigh-rate episodesAdditional risk factorsCRT-D devicesStroke risk stratificationCommon cardiac arrhythmiaAHRE burdenElectrocardiographic documentationMajor bleedingSystemic embolismProphylactic therapyClinical characteristicsStroke riskAnticoagulation decisionsClinical features
2008
Newly Diagnosed Arrhythmogenic Right Ventricular Dysplasia in an Octogenarian
AKAR JG, SINGH M, AUSEON AJ, WILBER DJ. Newly Diagnosed Arrhythmogenic Right Ventricular Dysplasia in an Octogenarian. Journal Of Cardiovascular Electrophysiology 2008, 19: 1316-1318. PMID: 18631265, DOI: 10.1111/j.1540-8167.2008.01241.x.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overArrhythmogenic Right Ventricular DysplasiaElectrocardiographyHumansMaleConceptsARVD/CArrhythmogenic right ventricular dysplasia/cardiomyopathyRight ventricular dysplasia/cardiomyopathyVentricular dysplasia/cardiomyopathyArrhythmogenic right ventricular dysplasiaARVD/C.Right ventricular dysplasiaYears of ageElderly patientsOlder patientsVentricular dysplasiaCase reportPatientsDiagnosisOctogenariansReportCardiomyopathyDysplasiaYearsDiseaseProspective Study of Atrial Fibrillation Termination During Ablation Guided by Automated Detection of Fractionated Electrograms
PORTER M, SPEAR W, AKAR JG, HELMS R, BRYSIEWICZ N, SANTUCCI P, WILBER DJ. Prospective Study of Atrial Fibrillation Termination During Ablation Guided by Automated Detection of Fractionated Electrograms. Journal Of Cardiovascular Electrophysiology 2008, 19: 613-620. PMID: 18462320, DOI: 10.1111/j.1540-8167.2008.01189.x.Peer-Reviewed Original ResearchConceptsPersistent atrial fibrillationAtrial fibrillationParoxysmal atrial fibrillationInitial AF ablationOne-year freedomRecurrent atrial arrhythmiasSingle-procedure outcomesAntiarrhythmic drug therapySelection of patientsSpontaneous atrial fibrillationSites/patientAF termination rateHigher AF termination rateAtrial fibrillation terminationAF ablationProspective studyAtrial arrhythmiasPulmonary veinsDrug therapyAdditional ablationAtrial septumProcedure outcomesPatientsAtrial electrogramsCFAE sites
2006
Predicting elevated defibrillation energy requirements in heart failure with reasonable probability
Akar JG. Predicting elevated defibrillation energy requirements in heart failure with reasonable probability. Heart Rhythm 2006, 3: 1017-1018. PMID: 16945793, DOI: 10.1016/j.hrthm.2006.06.015.Peer-Reviewed Original ResearchIdiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva
Daniels DV, Lu YY, Morton JB, Santucci PA, Akar JG, Green A, Wilber DJ. Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva. Circulation 2006, 113: 1659-1666. PMID: 16567566, DOI: 10.1161/circulationaha.105.611640.Peer-Reviewed Original ResearchConceptsIdiopathic ventricular tachycardiaMaximum deflection indexVentricular tachycardiaEpicardial ventricular tachycardiaDirect surgical ablationSinus of ValsalvaLeft ventricular epicardiumDeflection indexSite of originUnsuccessful ablationAortic sinusVenous mappingCatheter ablationOccasional patientSurgical ablationCoronary veinVT inductionTranspericardial approachVentricular sitesEndocardial activationEpicardial mappingPerivascular sitesECG patternVentricular endocardiumAnatomic constraints
2005
Chagas myocarditis and syncope.
Patel RA, DiMarco JP, Akar JG, Voros S, Kramer CM. Chagas myocarditis and syncope. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 685-8. PMID: 16136859, DOI: 10.1081/jcmr-65627.Peer-Reviewed Original Research
2002
Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation
AKAR JG, EVERETT TH, KOK L, MOORMAN JR, HAINES DE. Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2002, 13: 1027-1034. PMID: 12435191, DOI: 10.1046/j.1540-8167.2002.01027.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAtrial FibrillationAtrial FunctionDisease Models, AnimalDogsElectrocardiographyElectrophysiologic Techniques, CardiacEntropyFemaleFollow-Up StudiesHeart AtriaModels, CardiovascularRecovery of FunctionRefractory Period, ElectrophysiologicalSeverity of Illness IndexStatistics as TopicTreatment OutcomeConceptsAtrial effective refractory periodPersistent atrial fibrillationAcute atrial fibrillationAtrial fibrillationStructural remodelingSinus rhythmMean atrial effective refractory periodEffective refractory periodAtrial sizeElectrical remodelingLeft atriumBasket catheterAF dogsIntracardiac echocardiographyAtrial electrogramsRefractory periodRemodelingFibrillationSpatiotemporal organizationRhythmAcuteEchocardiographyCatheterMajor roleRecovery
2001
Tachycardia with Atrioventricular Dissociation after Surgery for Single Ventricle
AKAR J, DIMARCO J. Tachycardia with Atrioventricular Dissociation after Surgery for Single Ventricle. Journal Of Cardiovascular Electrophysiology 2001, 12: 1092-1093. PMID: 11573704, DOI: 10.1046/j.1540-8167.2001.01092.x.Peer-Reviewed Original ResearchCoexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease
Akar J, Kok L, Haines D, DiMarco J, Mounsey J. Coexistence of type I atrial flutter and intra-atrial re-entrant tachycardia in patients with surgically corrected congenital heart disease. Journal Of The American College Of Cardiology 2001, 38: 377-384. PMID: 11499727, DOI: 10.1016/s0735-1097(01)01392-4.Peer-Reviewed Original ResearchConceptsIntra-atrial re-entrant tachycardiaIsthmus-dependent atrial flutterCongenital heart diseaseRe-entrant tachycardiaAtrial flutterHeart diseaseType I atrial flutterSurface electrocardiogramInferior vena cavaSlow conduction zoneRe-entrant tachyarrhythmiasLateral right atriumAtriotomy scarCoexistent arrhythmiaIART recurrenceConsecutive patientsAtrial tachyarrhythmiasProcedural complicationsSupraventricular tachyarrhythmiasFurther recurrenceSuccessful ablationRight atriumVena cavaSurgical correctionEntrainment mappingAssessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial Defibrillation
Everett T, Moorman J, Kok L, Akar J, Haines D. Assessment of Global Atrial Fibrillation Organization to Optimize Timing of Atrial Defibrillation. Circulation 2001, 103: 2857-2861. PMID: 11401945, DOI: 10.1161/01.cir.103.23.2857.Peer-Reviewed Original Research