2022
PO-657-07 SPONTANEOUS RESTORATION OF SINUS RHYTHM AFTER INTER ATRIAL SHUNT PLACEMENT IN A PATIENT WITH LONGSTANDING PERSISTENT ATRIAL FIBRILLATION
Ziki M, Hummel J, Lampert R, Akar J. PO-657-07 SPONTANEOUS RESTORATION OF SINUS RHYTHM AFTER INTER ATRIAL SHUNT PLACEMENT IN A PATIENT WITH LONGSTANDING PERSISTENT ATRIAL FIBRILLATION. Heart Rhythm 2022, 19: s273-s274. DOI: 10.1016/j.hrthm.2022.03.295.Peer-Reviewed Original Research
2020
Understanding tricuspid valve remodelling in atrial fibrillation using three-dimensional echocardiography.
Ortiz-Leon XA, Posada-Martinez EL, Trejo-Paredes MC, Ivey-Miranda JB, Pereira J, Crandall I, DaSilva P, Bouman E, Brooks A, Gerardi C, Ugonabo I, Chen W, Houle H, Akar JG, Lin BA, McNamara RL, Lombo-Lievano B, Arias-Godinez JA, Sugeng L. Understanding tricuspid valve remodelling in atrial fibrillation using three-dimensional echocardiography. European Heart Journal - Cardiovascular Imaging 2020, 21: 747-755. PMID: 32372089, DOI: 10.1093/ehjci/jeaa058.Peer-Reviewed Original ResearchConceptsLeft heart diseaseSevere tricuspid regurgitationTricuspid regurgitationAtrial fibrillationTransoesophageal echocardiographyBiatrial dilatationHigher systolic pulmonary artery pressureNormal right ventricular sizeSystolic pulmonary artery pressureImpact of AFSevere functional tricuspid regurgitationTricuspid annulus dilationPulmonary artery pressureRight ventricular sizeFunctional tricuspid regurgitationFractional area changeTA fractional area changeThree-dimensional echocardiographyRV enlargementArtery pressureBiventricular functionTricuspid valveVentricular sizeAF groupSinus rhythm
2013
Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion
Mukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, DeSantis SM, Spinale FG, Gold MR. Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion. Journal Of Cardiovascular Translational Research 2013, 6: 528-535. PMID: 23722357, DOI: 10.1007/s12265-013-9471-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationBiomarkersC-Reactive ProteinChi-Square DistributionElectric CountershockFibrosisHeart AtriaHumansLogistic ModelsMatrix MetalloproteinasesMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPeptide FragmentsPredictive Value of TestsRecurrenceRisk FactorsTime FactorsTissue Inhibitor of MetalloproteinasesTreatment OutcomeConceptsAF recurrenceMatrix metalloproteinasesMMP-9TIMP-4MMP-3N-terminus pro B type natriuretic peptideHigh-sensitivity C-reactive protein levelsPro-B-type natriuretic peptideTissue inhibitorC-reactive protein levelsB-type natriuretic peptideLevels of MMPsAtrial fibrillation recurrenceNovel biomarker panelAtrial volumeNatriuretic peptideAtrial fibrosisSinus rhythmPredicts RecurrenceBiomarker panelRecurrenceMultivariate analysisPostcardioversionProtein levelsPlasma samples
2010
Pericardial Fat Is Independently Associated With Human Atrial Fibrillation
Chekakie M, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG. Pericardial Fat Is Independently Associated With Human Atrial Fibrillation. Journal Of The American College Of Cardiology 2010, 56: 784-788. PMID: 20797492, DOI: 10.1016/j.jacc.2010.03.071.Peer-Reviewed Original ResearchConceptsPericardial fat volumeParoxysmal atrial fibrillationPersistent atrial fibrillationAtrial fibrillationPericardial fatFat volumeAtrial enlargementSinus rhythmPathogenesis of AFSinus rhythm groupTraditional risk factorsVentricular ejection fractionValvular heart diseaseBody mass indexVisceral adipose tissuePersistent AF patientsHuman atrial fibrillationAF independentAF patientsDiabetes mellitusEjection fractionMass indexHeart diseaseRisk factorsInflammatory properties
2007
Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE Procedures
AKAR JG, AL‐CHEKAKIE M, HAI A, BRYSIEWICZ N, PORTER M, VARMA N, SANTUCCI P, WILBER DJ. Surface Electrocardiographic Patterns and Electrophysiologic Characteristics of Atrial Flutter Following Modified Radiofrequency MAZE Procedures. Journal Of Cardiovascular Electrophysiology 2007, 18: 349-355. PMID: 17394449, DOI: 10.1111/j.1540-8167.2007.00761.x.Peer-Reviewed Original ResearchConceptsCavo-tricuspid isthmusIsthmus ablationAtrial flutterElectrophysiological characteristicsElectrophysiological studiesECG appearanceCox maze III procedureIsthmus-dependent right atrial flutterRadiofrequency maze procedureSurface electrocardiographic patternsMitral isthmus ablationRight atrial flutterDiagnostic electrophysiological studyShorter cycle lengthsLA flutterPostoperative arrhythmiasRadiofrequency mazeCardiac surgeryConsecutive patientsAtrial circuitsAtrial fibrillationElectrophysiologic characteristicsSinus rhythmSurgical lesionsElectrocardiographic pattern
2005
8. Different Mapping Systems and Approaches for Ablation of Atrial Fibrillation
Wilber D, Lipman E, Madsen H, Lin A, Santucci P, Akar J, Anderson K, Dasari R, Joshi S, Gauri A. 8. Different Mapping Systems and Approaches for Ablation of Atrial Fibrillation. EP Europace 2005, 7: s14-s14. DOI: 10.1016/j.eupc.2005.08.054.Peer-Reviewed Original ResearchAtrial fibrillationCircumferential PV isolationPV isolationLeft atriumAF recurrenceLate recurrenceScar indexHistory of AFGreater LA dimensionLow ejection fractionRecurrent atrial fibrillationPulmonary vein isolationPersistent atrial fibrillationPulmonary vein ostiaLA scarringVein isolationEjection fractionPV ostiaClinical variablesSinus rhythmCircumferential ablationLA dimensionAdditional interventionsNormal controlsMultivariate analysis
2003
Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation
Akar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation. Circulation 2003, 107: 1810-1815. PMID: 12665494, DOI: 10.1161/01.cir.0000058462.23347.93.Peer-Reviewed Original ResearchConceptsEffective refractory periodLeft atrial appendageAtrial fibrillationMitochondrial Ca overloadWhole-cell ClWhole-cell NaIntracellular chloride accumulationIntracellular Cl- accumulationSinus rhythmAtrial appendageCa overloadElectrical remodelingAF pathogenesisRapid pacingRefractory periodTransient increaseTransverse cryosectionsMembrane depolarizationFibrillationNovel findingsCytosolic CaCytoplasmic CaConcomitant increaseIon channelsMinutes
2002
Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation
AKAR JG, EVERETT TH, KOK L, MOORMAN JR, HAINES DE. Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2002, 13: 1027-1034. PMID: 12435191, DOI: 10.1046/j.1540-8167.2002.01027.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAtrial FibrillationAtrial FunctionDisease Models, AnimalDogsElectrocardiographyElectrophysiologic Techniques, CardiacEntropyFemaleFollow-Up StudiesHeart AtriaModels, CardiovascularRecovery of FunctionRefractory Period, ElectrophysiologicalSeverity of Illness IndexStatistics as TopicTreatment OutcomeConceptsAtrial effective refractory periodPersistent atrial fibrillationAcute atrial fibrillationAtrial fibrillationStructural remodelingSinus rhythmMean atrial effective refractory periodEffective refractory periodAtrial sizeElectrical remodelingLeft atriumBasket catheterAF dogsIntracardiac echocardiographyAtrial electrogramsRefractory periodRemodelingFibrillationSpatiotemporal organizationRhythmAcuteEchocardiographyCatheterMajor roleRecovery