Featured Publications
Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Martínez-Magaña JJ, Genis-Mendoza AD, Villatoro Velázquez JA, Bustos-Gamiño M, Juárez-Rojop IE, Tovilla-Zarate CA, Sarmiento E, Saucedo E, Rodríguez-Mayoral O, Fleiz-Bautista C, Camarena B, Aguilar A, Gonzalez-Castro TB, Medina-Mora ME, Nicolini H. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports 2021, 11: 6771. PMID: 33762635, PMCID: PMC7990941, DOI: 10.1038/s41598-021-85881-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesBiological Variation, PopulationComorbidityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedPolymorphism, Single NucleotidePublic Health SurveillanceQuantitative Trait LociRisk AssessmentRisk FactorsSubstance-Related DisordersYoung AdultConceptsGenome-wide association studiesGenome-wide correlationSingle nucleotide polymorphismsVertical pleiotropyAssociation studiesWide association signalsGenome-wide associationPolygenic risk scoresQuantitative lociAssociation signalsPhagocytosis pathwayNominal associationTraitsPleiotropyPathwayMeQTLMendelian randomizationGenesLociHigher polygenic risk scoreMicroarrayMultiple logistic modelMexican populationCommon comorbiditiesPolymorphism
2024
Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder
Zillich E, Belschner H, Avetyan D, Andrade-Brito D, Martínez-Magaña J, Frank J, Mechawar N, Turecki G, Cabana-Domínguez J, Fernàndez-Castillo N, Cormand B, Montalvo-Ortiz J, Nöthen M, Hansson A, Rietschel M, Spanagel R, Witt S, Zillich L. Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder. Translational Psychiatry 2024, 14: 428. PMID: 39384764, PMCID: PMC11464785, DOI: 10.1038/s41398-024-03139-9.Peer-Reviewed Original ResearchConceptsCocaine use disorderUse disorderAlternative splicingHuman prefrontal cortexProfiling of DNA methylationBrodmann area 9Differential alternative splicingDeregulated biological processesPostmortem brain tissueMulti-omics approachCocaine intakeMulti-omics studiesPrefrontal cortexBrain alterationsMulti-omics profilingGene expression alterationsArea 9Fatty acid metabolismReceptor-targeting drugsSpliced transcriptsEpigenome-wideDNA methylationNeuronal morphogenesisAS changesDrug repositioning analysisPhenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels
Nolasco-Rosales G, Martínez-Magaña J, Juárez-Rojop I, Rodríguez-Sánchez E, Ruiz-Ramos D, Villatoro-Velázquez J, Bustos-Gamiño M, Medina-Mora M, Tovilla-Zárate C, Cruz-Castillo J, Nicolini H, Genis-Mendoza A. Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels. International Journal Of Molecular Sciences 2024, 25: 10154. PMID: 39337639, PMCID: PMC11432505, DOI: 10.3390/ijms251810154.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPhenome-wide association studyAssociation studiesGenetics of LADANon-European populationsGenome-wideGenetic risk factorsGENESIS packageSoutheastern MexicoPopulation implicationsPheWASFAIM2Risk genotypesAnti-glutamic acid decarboxylase autoantibodiesGlutamate decarboxylase autoantibodiesAutoimmune diabetesBody adiposity measuresMexican populationLatent autoimmune diabetesPLINKBody mass indexGenesAdiposity measuresChildhood obesityType 2 diabetes
2021
Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning
Cabrera‐Mendoza B, Martínez‐Magaña J, Monroy‐Jaramillo N, Genis‐Mendoza A, Fresno C, Fries GR, Walss‐Bass C, Armenta M, García‐Dolores F, Díaz‐Otañez C, Flores G, Vázquez‐Roque R, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 193-206. PMID: 33403748, DOI: 10.1002/ajmg.b.32830.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersBrain gene co-expression networksHub genesPotential pharmacological targetPost-mortem samplesPharmacological treatmentHigh riskCandidate treatmentPharmacological targetsSuicidal behaviorMAOA inhibitorsPrefrontal cortexNonsuicidesDGIdb databaseGene expression profilesPatientsCo-expression networkSuicideDisordersDrugsTreatmentDrug repositioningExpression profilesIndividuals
2019
Gene‐level genome‐wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population
González‐Castro T, Martínez‐Magaña J, Tovilla‐Zárate C, Juárez‐Rojop I, Sarmiento E, Genis‐Mendoza A, Nicolini H. Gene‐level genome‐wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population. Molecular Genetics & Genomic Medicine 2019, 7: e983. PMID: 31578828, PMCID: PMC6900393, DOI: 10.1002/mgg3.983.Peer-Reviewed Original ResearchAssociation between APOE polymorphisms and lipid profile in Mexican Amerindian population
Martínez‐Magaña J, Genis‐Mendoza A, Tovilla‐Zarate C, González‐Castro T, Juárez-Rojop IE, Hernández‐Díaz Y, Martinez‐Hernandez A, Garcia‐Ortíz H, Orozco L, López‐Narvaez M, Nicolini H. Association between APOE polymorphisms and lipid profile in Mexican Amerindian population. Molecular Genetics & Genomic Medicine 2019, 7: e958. PMID: 31557780, PMCID: PMC6825948, DOI: 10.1002/mgg3.958.Peer-Reviewed Original ResearchConceptsLDL-C levelsHDL-C levelsLipid profileLipoprotein cholesterolTotal cholesterolBiochemical variablesHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolHigher HDL-C levelsMexican Amerindian populationsAPOE e4 carriersDifferent APOE allelesObese individualsGene allelesApoE E3E2 alleleApoE isoformsAPOE polymorphismE4 alleleApolipoprotein EAnthropometric measurementsKruskal-Wallis testAPOE allelesLipid metabolismE3 alleleExploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers
Rodríguez‐López M, Martínez‐Magaña J, Cabrera‐Mendoza B, Genis‐Mendoza A, García‐Dolores F, López‐Armenta M, Flores G, Vázquez‐Roque R, Nicolini H. Exploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 183: 26-37. PMID: 31418530, DOI: 10.1002/ajmg.b.32752.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociQuantitative trait lociTrait lociExpression of genesGene expressionGenetic variantsMethylation quantitative trait lociGene expression regulationExpression regulationCandidate genetic variantsDNA methylationMolecular traitsTranscription factorsEnhancer activityCell organizationRegulatory mechanismsGenetic factorsGenotype dataMultiple biological systemsLociGenesExpressionBiological systemsRegulationVariantsGenetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population
Genis‐Mendoza A, Ruiz‐Ramos D, López‐Narvaez M, Tovilla‐Zárate C, García A, Meda G, Martinez‐Magaña J, González‐Castro T, Juárez‐Rojop I, Nicolini H. Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population. Brain And Behavior 2019, 9: e01286. PMID: 31199591, PMCID: PMC6625474, DOI: 10.1002/brb3.1286.Peer-Reviewed Original ResearchDifferential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population
Saucedo‐Uribe E, Genis‐Mendoza A, Díaz‐Anzaldúa A, Martínez‐Magaña J, Tovilla‐Zarate C, Juárez‐Rojop I, Lanzagorta N, Escamilla M, González‐Castro T, Narvaez M, Hernández‐Díaz Y, Nicolini H. Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population. Brain And Behavior 2019, 9: e01249. PMID: 31033179, PMCID: PMC6576176, DOI: 10.1002/brb3.1249.Peer-Reviewed Original Research
2016
Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations
Gonzalez-Covarrubias V, Martínez-Magaña JJ, Coronado-Sosa R, Villegas-Torres B, Genis-Mendoza AD, Canales-Herrerias P, Nicolini H, Soberón X. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations. Pharmaceutical Research 2016, 33: 2644-2652. PMID: 27387170, DOI: 10.1007/s11095-016-1990-5.Peer-Reviewed Original ResearchConceptsGenetic variantsMajor continental groupsAllele frequency differencesSolute carrier gene familySignificant allele differencesDifferent Mexican populationsGene familyContinental groupsAllele differencesMexican MestizosAllele frequenciesRelevant targetsMore variationDifferent populationsDrug responseMexican populationPharmacogenetic variantsNative groupsVariantsPharmacogenetic targetsDifferent native groupsPopulationMicroarrayTransportersTarget