Featured Publications
Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Martínez-Magaña JJ, Genis-Mendoza AD, Villatoro Velázquez JA, Bustos-Gamiño M, Juárez-Rojop IE, Tovilla-Zarate CA, Sarmiento E, Saucedo E, Rodríguez-Mayoral O, Fleiz-Bautista C, Camarena B, Aguilar A, Gonzalez-Castro TB, Medina-Mora ME, Nicolini H. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports 2021, 11: 6771. PMID: 33762635, PMCID: PMC7990941, DOI: 10.1038/s41598-021-85881-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesBiological Variation, PopulationComorbidityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedPolymorphism, Single NucleotidePublic Health SurveillanceQuantitative Trait LociRisk AssessmentRisk FactorsSubstance-Related DisordersYoung AdultConceptsGenome-wide association studiesGenome-wide correlationSingle nucleotide polymorphismsVertical pleiotropyAssociation studiesWide association signalsGenome-wide associationPolygenic risk scoresQuantitative lociAssociation signalsPhagocytosis pathwayNominal associationTraitsPleiotropyPathwayMeQTLMendelian randomizationGenesLociHigher polygenic risk scoreMicroarrayMultiple logistic modelMexican populationCommon comorbiditiesPolymorphism
2024
Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels
Nolasco-Rosales G, Martínez-Magaña J, Juárez-Rojop I, Rodríguez-Sánchez E, Ruiz-Ramos D, Villatoro-Velázquez J, Bustos-Gamiño M, Medina-Mora M, Tovilla-Zárate C, Cruz-Castillo J, Nicolini H, Genis-Mendoza A. Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels. International Journal Of Molecular Sciences 2024, 25: 10154. PMID: 39337639, PMCID: PMC11432505, DOI: 10.3390/ijms251810154.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPhenome-wide association studyAssociation studiesGenetics of LADANon-European populationsGenome-wideGenetic risk factorsGENESIS packageSoutheastern MexicoPopulation implicationsPheWASFAIM2Risk genotypesAnti-glutamic acid decarboxylase autoantibodiesGlutamate decarboxylase autoantibodiesAutoimmune diabetesBody adiposity measuresMexican populationLatent autoimmune diabetesPLINKBody mass indexGenesAdiposity measuresChildhood obesityType 2 diabetesA phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
Jennings M, Martínez-Magaña J, Courchesne-Krak N, Cupertino R, Vilar-Ribó L, Bianchi S, Hatoum A, Atkinson E, Giusti-Rodriguez P, Montalvo-Ortiz J, Gelernter J, Artigas M, 23andMe I, Aslibekyan S, Auton A, Babalola E, Bell R, Bielenberg J, Bryc K, Bullis E, Coker D, Partida G, Dhamija D, Das S, Elson S, Eriksson N, Filshtein T, Fitch A, Fletez-Brant K, Fontanillas P, Freyman W, Granka J, Heilbron K, Hernandez A, Hicks B, Hinds D, Jewett E, Jiang Y, Kukar K, Kwong A, Lin K, Llamas B, Lowe M, McCreight J, McIntyre M, Micheletti S, Moreno M, Nandakumar P, Nguyen D, Noblin E, O'Connell J, Petrakovitz A, Poznik G, Reynoso A, Schumacher M, Shastri A, Shelton J, Shi J, Shringarpure S, Su Q, Tat S, Tchakouté C, Tran V, Tung J, Wang X, Wang W, Weldon C, Wilton P, Wong C, Elson S, Edenberg H, Fontanillas P, Palmer A, Sanchez-Roige S. A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. EBioMedicine 2024, 103: 105086. PMID: 38580523, PMCID: PMC11121167, DOI: 10.1016/j.ebiom.2024.105086.Peer-Reviewed Original ResearchConceptsMultiple domains of healthDomains of healthEffects of alcohol consumptionAlcohol consumptionHealth outcomesPhenome-wide association studyAlcohol-related behaviorsCardio-metabolic healthPotential causal effectMendelian randomisation studiesGenome-wide association studiesPhenome-wide associationMR analysisPheWAS associationsMultiple domainsHypothesis-free approachPreventive medicineDiverse cohortPheWASAssociation studiesHealthReproductive healthAlcohol behaviorConsequences of drinkingEuropean cohort
2021
Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results
Nolasco-Rosales GA, Martínez-Magaña JJ, Juárez-Rojop IE, González-Castro TB, Tovilla-Zarate CA, García AR, Sarmiento E, Ruiz-Ramos D, Genis-Mendoza AD, Nicolini H. Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results. Nutrients 2021, 13: 3210. PMID: 34579086, PMCID: PMC8470254, DOI: 10.3390/nu13093210.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentDNA MethylationEpigenesis, GeneticFeeding and Eating DisordersGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseGenotypeHumansMexicoPolymorphism, Single Nucleotide
2019
Gene‐level genome‐wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population
González‐Castro T, Martínez‐Magaña J, Tovilla‐Zárate C, Juárez‐Rojop I, Sarmiento E, Genis‐Mendoza A, Nicolini H. Gene‐level genome‐wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population. Molecular Genetics & Genomic Medicine 2019, 7: e983. PMID: 31578828, PMCID: PMC6900393, DOI: 10.1002/mgg3.983.Peer-Reviewed Original ResearchExploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers
Rodríguez‐López M, Martínez‐Magaña J, Cabrera‐Mendoza B, Genis‐Mendoza A, García‐Dolores F, López‐Armenta M, Flores G, Vázquez‐Roque R, Nicolini H. Exploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 183: 26-37. PMID: 31418530, DOI: 10.1002/ajmg.b.32752.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociQuantitative trait lociTrait lociExpression of genesGene expressionGenetic variantsMethylation quantitative trait lociGene expression regulationExpression regulationCandidate genetic variantsDNA methylationMolecular traitsTranscription factorsEnhancer activityCell organizationRegulatory mechanismsGenetic factorsGenotype dataMultiple biological systemsLociGenesExpressionBiological systemsRegulationVariantsGenetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population
Genis‐Mendoza A, Ruiz‐Ramos D, López‐Narvaez M, Tovilla‐Zárate C, García A, Meda G, Martinez‐Magaña J, González‐Castro T, Juárez‐Rojop I, Nicolini H. Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population. Brain And Behavior 2019, 9: e01286. PMID: 31199591, PMCID: PMC6625474, DOI: 10.1002/brb3.1286.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesComorbidityFeeding and Eating DisordersFemaleGenetic Predisposition to DiseaseHumansMaleMexicoMiddle AgedPolymorphism, Single NucleotideReceptor, Serotonin, 5-HT2ASuicide, AttemptedDifferential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population
Saucedo‐Uribe E, Genis‐Mendoza A, Díaz‐Anzaldúa A, Martínez‐Magaña J, Tovilla‐Zarate C, Juárez‐Rojop I, Lanzagorta N, Escamilla M, González‐Castro T, Narvaez M, Hernández‐Díaz Y, Nicolini H. Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population. Brain And Behavior 2019, 9: e01249. PMID: 31033179, PMCID: PMC6576176, DOI: 10.1002/brb3.1249.Peer-Reviewed Original Research