2021
Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning
Cabrera‐Mendoza B, Martínez‐Magaña J, Monroy‐Jaramillo N, Genis‐Mendoza A, Fresno C, Fries GR, Walss‐Bass C, Armenta M, García‐Dolores F, Díaz‐Otañez C, Flores G, Vázquez‐Roque R, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 193-206. PMID: 33403748, DOI: 10.1002/ajmg.b.32830.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersBrain gene co-expression networksHub genesPotential pharmacological targetPost-mortem samplesPharmacological treatmentHigh riskCandidate treatmentPharmacological targetsSuicidal behaviorMAOA inhibitorsPrefrontal cortexNonsuicidesDGIdb databaseGene expression profilesPatientsCo-expression networkSuicideDisordersDrugsTreatmentDrug repositioningExpression profilesIndividuals
2018
Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats
Solis-Medina A, Martínez-Magaña JJ, Quintanar-Jurado V, Gallegos-Silva I, Juárez-Rojop IE, Tovilla-Zárate CA, Díaz-Zagoya JC, Hernández-Díaz Y, González-Castro TB, López-Narváez ML, Genis-Mendoza AD, Nicolini H. Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats. Metabolic Brain Disease 2018, 33: 2031-2038. PMID: 30264280, DOI: 10.1007/s11011-018-0310-7.Peer-Reviewed Original ResearchConceptsMale Wistar ratsNeuronal specific enolaseNeuronal viabilityWistar ratsPrefrontal cortexChronic consumptionNeural viabilityConsumption of aspartameHematoxylin-eosin stainingConsumption of sweetenersHistological alterationsAstrogliosisImmunohistochemical techniquesBrain areasControl groupNeural modificationsNeuronal morphologyPyknotic nucleiHistological analysisHippocampusAmygdalaRatsCortexEarly ageEarly consumption