Featured Publications
Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Martínez-Magaña JJ, Genis-Mendoza AD, Villatoro Velázquez JA, Bustos-Gamiño M, Juárez-Rojop IE, Tovilla-Zarate CA, Sarmiento E, Saucedo E, Rodríguez-Mayoral O, Fleiz-Bautista C, Camarena B, Aguilar A, Gonzalez-Castro TB, Medina-Mora ME, Nicolini H. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports 2021, 11: 6771. PMID: 33762635, PMCID: PMC7990941, DOI: 10.1038/s41598-021-85881-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesBiological Variation, PopulationComorbidityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedPolymorphism, Single NucleotidePublic Health SurveillanceQuantitative Trait LociRisk AssessmentRisk FactorsSubstance-Related DisordersYoung AdultConceptsGenome-wide association studiesGenome-wide correlationSingle nucleotide polymorphismsVertical pleiotropyAssociation studiesWide association signalsGenome-wide associationPolygenic risk scoresQuantitative lociAssociation signalsPhagocytosis pathwayNominal associationTraitsPleiotropyPathwayMeQTLMendelian randomizationGenesLociHigher polygenic risk scoreMicroarrayMultiple logistic modelMexican populationCommon comorbiditiesPolymorphism
2024
Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels
Nolasco-Rosales G, Martínez-Magaña J, Juárez-Rojop I, Rodríguez-Sánchez E, Ruiz-Ramos D, Villatoro-Velázquez J, Bustos-Gamiño M, Medina-Mora M, Tovilla-Zárate C, Cruz-Castillo J, Nicolini H, Genis-Mendoza A. Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels. International Journal Of Molecular Sciences 2024, 25: 10154. PMID: 39337639, PMCID: PMC11432505, DOI: 10.3390/ijms251810154.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPhenome-wide association studyAssociation studiesGenetics of LADANon-European populationsGenome-wideGenetic risk factorsGENESIS packageSoutheastern MexicoPopulation implicationsPheWASFAIM2Risk genotypesAnti-glutamic acid decarboxylase autoantibodiesGlutamate decarboxylase autoantibodiesAutoimmune diabetesBody adiposity measuresMexican populationLatent autoimmune diabetesPLINKBody mass indexGenesAdiposity measuresChildhood obesityType 2 diabetes
2023
W70. ASSOCIATION BETWEEN MBD5 GENE AND DEPRESSIVE SYMPTOMATOLOGY IN MEXICAN POPULATION: RESULTS FROM MXGDAR/ENCODAT COHORT
Camarena B, Sanabrais-Jiménez M, García A, Genis A, Villatoro-Velazquez J, Fleiz-Bautista C, Bustos-Gamiño M, Martínez-Magaña J, Nicolini H, Medina-Mora M. W70. ASSOCIATION BETWEEN MBD5 GENE AND DEPRESSIVE SYMPTOMATOLOGY IN MEXICAN POPULATION: RESULTS FROM MXGDAR/ENCODAT COHORT. European Neuropsychopharmacology 2023, 75: s141. DOI: 10.1016/j.euroneuro.2023.08.257.Peer-Reviewed Original ResearchDepressive symptomsAnxiety symptomsAnxiety disordersSubstantial disease burdenMexican populationGenetic principal componentsYears of lifeGeneralized anxiety disorderFindings of associationsDisease burdenHealthy controlsMexican cohortMajor depressiveGeneral populationDiagnostic criteriaLifetime symptomatologyGenetic overlapSymptomsMBD5 geneDepressiveBackground AnxietyCohortProtein 5DepressionGreater mortality
2021
Mental Health Problems Due to Social Isolation During the COVID-19 Pandemic in a Mexican Population
Genis-Mendoza A, Martínez-Magaña J, López-Narváez M, González-Castro T, Juárez-Rojop I, Nicolini H, Tovilla-Zárate C, Castillo-Avila R. Mental Health Problems Due to Social Isolation During the COVID-19 Pandemic in a Mexican Population. Frontiers In Public Health 2021, 9: 703450. PMID: 34888275, PMCID: PMC8649920, DOI: 10.3389/fpubh.2021.703450.Peer-Reviewed Original ResearchConceptsSymptoms of depressionDepressive symptomsSocial isolationPost-traumatic stressMexican populationSuicidal ideationCOVID-19 pandemicMental healthLow-calorie dietPersonal hygiene habitsYears of ageCOVID-19Cross-sectional online surveyMental health problemsHygiene habitsRisk factorsPsychiatric symptomsGeneral populationHealth problemsMental disordersSymptomsEating habitsPersonal hygieneDepressionPsychoactive substances
2019
Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population
Genis‐Mendoza A, Ruiz‐Ramos D, López‐Narvaez M, Tovilla‐Zárate C, García A, Meda G, Martinez‐Magaña J, González‐Castro T, Juárez‐Rojop I, Nicolini H. Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population. Brain And Behavior 2019, 9: e01286. PMID: 31199591, PMCID: PMC6625474, DOI: 10.1002/brb3.1286.Peer-Reviewed Original Research
2016
Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations
Gonzalez-Covarrubias V, Martínez-Magaña JJ, Coronado-Sosa R, Villegas-Torres B, Genis-Mendoza AD, Canales-Herrerias P, Nicolini H, Soberón X. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations. Pharmaceutical Research 2016, 33: 2644-2652. PMID: 27387170, DOI: 10.1007/s11095-016-1990-5.Peer-Reviewed Original ResearchConceptsGenetic variantsMajor continental groupsAllele frequency differencesSolute carrier gene familySignificant allele differencesDifferent Mexican populationsGene familyContinental groupsAllele differencesMexican MestizosAllele frequenciesRelevant targetsMore variationDifferent populationsDrug responseMexican populationPharmacogenetic variantsNative groupsVariantsPharmacogenetic targetsDifferent native groupsPopulationMicroarrayTransportersTarget