Featured Publications
Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes
Pérez-Aldana B, Martínez-Magaña J, Mayén-Lobo Y, de Montellano D, Aviña-Cervantes C, Ortega-Vázquez A, Genis-Mendoza A, Sarmiento E, Soto-Reyes E, Juárez-Rojop I, Tovilla-Zarate C, González-Castro T, Nicolini H, López-López M, Monroy-Jaramillo N. Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers In Psychiatry 2022, 13: 870656. PMID: 35664466, PMCID: PMC9157596, DOI: 10.3389/fpsyt.2022.870656.Peer-Reviewed Original ResearchPathway genesDNA methylomeEpigenetic ageProtein-protein interactionsLong-term treatmentDifferential methylation sitesInfinium MethylationEPIC BeadChipMethylation sitesPsychopharmacological treatmentMethylationEPIC BeadChipContinuous clozapine treatmentDrug-naive patientsGenesMethylomeYears of treatmentLower mortality rateChronological ageCLZ treatmentClozapine treatmentMale patientsDelta agePsychiatric disordersPatientsPsychotic disordersMortality rate
2024
Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology
Martínez-Magaña J, Hurtado-Soriano J, Rivero-Segura N, Montalvo-Ortiz J, Garcia-delaTorre P, Becerril-Rojas K, Gomez-Verjan J. Towards a Novel Frontier in the Use of Epigenetic Clocks in Epidemiology. Archives Of Medical Research 2024, 55: 103033. PMID: 38955096, DOI: 10.1016/j.arcmed.2024.103033.Peer-Reviewed Original ResearchImpact of public health interventionsHealth problems associated with agingPublic health interventionsPublic health strategiesEpigenetic clocksEfficacy of interventionsProblems associated with agingBiological agePublic health concernHealth interventionsHealth strategiesAssociated with ageDNA methylation levelsHuman phenomeHealthy agingHealth concernEpigenetic ageMultiple traitsHealthMethylation levelsInterventionAssociationAgeEpidemiological contextHealth span
2023
Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study
Nolasco-Rosales G, Alonso-García C, Hernández-Martínez D, Villar-Soto M, Martínez-Magaña J, Genis-Mendoza A, González-Castro T, Tovilla-Zarate C, Guzmán-Priego C, Martínez-López M, Nicolini H, Juárez-Rojop I. Aftereffects in Epigenetic Age Related to Cognitive Decline and Inflammatory Markers in Healthcare Personnel with Post-COVID-19: A Cross-Sectional Study. International Journal Of General Medicine 2023, 16: 4953-4964. PMID: 37928957, PMCID: PMC10625328, DOI: 10.2147/ijgm.s426249.Peer-Reviewed Original ResearchInflammatory markersPost-COVID conditionsHealthcare personnelLow PLRCognitive impairmentMini-Mental State Examination testEpigenetic ageCross-sectional studyIndicators of severityMontreal Cognitive AssessmentMild cognitive impairmentHigh NLRNeuropsychiatric manifestationsNeurological symptomsPsychiatric manifestationsHealthcare workersHigh MLRNeurocognitive changesPossible associationCognitive declinePhysical healthPLRCognitive AssessmentExamination testsAge
2021
Genome-wide DNA methylation profiling in nonagenarians suggests an effect of PM20D1 in late onset Alzheimer’s disease
Coto-Vílchez C, Martínez-Magaña J, Mora-Villalobos L, Valerio D, Genis-Mendoza A, Silverman J, Nicolini H, Raventós H, Chavarria-Soley G. Genome-wide DNA methylation profiling in nonagenarians suggests an effect of PM20D1 in late onset Alzheimer’s disease. CNS Spectrums 2021, 28: 174-182. PMID: 34911598, DOI: 10.1017/s109285292100105x.Peer-Reviewed Original ResearchGenome-wide DNA methylation profilingEpigenetic clocksWhole blood DNA methylation profilesQuantitative loci analysisCell cycle regulationDNA methylation profilesDNA methylation profilingEpigenetic ageMQTL SNPsBlood DNA methylation profilesHorvath's epigenetic clockInfinium MethylationEPIC BeadChipCycle regulationSynthesis of ceramideDifferential methylationMethylation profilingMethylation profilesLocus analysisMethylation levelsAverage methylationGenesMethylation analysisMethylationEPIC BeadChipPM20D1DMRs