2019
Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico
Gonzalez-Covarrubias V, Morales-Franco M, Cruz-Correa OF, Martínez-Hernández A, García-Ortíz H, Barajas-Olmos F, Genis-Mendoza AD, Martínez-Magaña JJ, Nicolini H, Orozco L, Soberón X. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico. Frontiers In Pharmacology 2019, 10: 1169. PMID: 31649539, PMCID: PMC6796793, DOI: 10.3389/fphar.2019.01169.Peer-Reviewed Original ResearchMajor continental groupsContinental groupsAllele frequenciesWide genetic variabilityNovel variationGenetic variabilityActionable pharmacogenetic variantsPharmacogenetic variantsGenesNovel SNVsFunctional impactNGS dataPharmacogenomic impactPharmacogenomics Knowledge BaseSequencing filesPharmacogenetic variationSNVsVariantsPharmacogenesAmerican populationActionable variantsPROVEANNativesFATHMMVariation
2016
Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations
Gonzalez-Covarrubias V, Martínez-Magaña JJ, Coronado-Sosa R, Villegas-Torres B, Genis-Mendoza AD, Canales-Herrerias P, Nicolini H, Soberón X. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations. Pharmaceutical Research 2016, 33: 2644-2652. PMID: 27387170, DOI: 10.1007/s11095-016-1990-5.Peer-Reviewed Original ResearchConceptsGenetic variantsMajor continental groupsAllele frequency differencesSolute carrier gene familySignificant allele differencesDifferent Mexican populationsGene familyContinental groupsAllele differencesMexican MestizosAllele frequenciesRelevant targetsMore variationDifferent populationsDrug responseMexican populationPharmacogenetic variantsNative groupsVariantsPharmacogenetic targetsDifferent native groupsPopulationMicroarrayTransportersTarget