Featured Publications
Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationGenome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
Martínez-Magaña JJ, Genis-Mendoza AD, Villatoro Velázquez JA, Bustos-Gamiño M, Juárez-Rojop IE, Tovilla-Zarate CA, Sarmiento E, Saucedo E, Rodríguez-Mayoral O, Fleiz-Bautista C, Camarena B, Aguilar A, Gonzalez-Castro TB, Medina-Mora ME, Nicolini H. Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. Scientific Reports 2021, 11: 6771. PMID: 33762635, PMCID: PMC7990941, DOI: 10.1038/s41598-021-85881-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllelesBiological Variation, PopulationComorbidityFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMental DisordersMiddle AgedPolymorphism, Single NucleotidePublic Health SurveillanceQuantitative Trait LociRisk AssessmentRisk FactorsSubstance-Related DisordersYoung AdultConceptsGenome-wide association studiesGenome-wide correlationSingle nucleotide polymorphismsVertical pleiotropyAssociation studiesWide association signalsGenome-wide associationPolygenic risk scoresQuantitative lociAssociation signalsPhagocytosis pathwayNominal associationTraitsPleiotropyPathwayMeQTLMendelian randomizationGenesLociHigher polygenic risk scoreMicroarrayMultiple logistic modelMexican populationCommon comorbiditiesPolymorphism
2024
F95. LOCAL ANCESTRY-AWARE META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES FOR ALCOHOL CONSUMPTION IN LATIN AMERICAN POPULATIONS
Martinez-Magana J, Atkinson E, Giusti-Rodriguez P, Santoro M, Wassertheil-Smoller S, Daviglus M, Perreira K, Nicolini H, Pereira A, Belangero S, Moyses-Oliveira M, Tucker K, Ordovas J, Villatoro-Velazquez J, Montalvo-Ortiz J. F95. LOCAL ANCESTRY-AWARE META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES FOR ALCOHOL CONSUMPTION IN LATIN AMERICAN POPULATIONS. European Neuropsychopharmacology 2024, 87: 256. DOI: 10.1016/j.euroneuro.2024.08.506.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide association study studiesAncestry-specific effectsIntergenic variantAlcohol consumptionAncestry-specific lociNative-American ancestryFrequency of alcohol consumptionAssociated with alcohol consumptionMeta-analysisLocal ancestryAdmixed populationsGWA studiesGenomic backgroundAssociation studiesSLIT3 geneMAGI1 genesGenomics ConsortiumGenetic associationGenesLatin American populationsAfrican ancestryGenetic liabilityUnited StatesAncestryPhenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels
Nolasco-Rosales G, Martínez-Magaña J, Juárez-Rojop I, Rodríguez-Sánchez E, Ruiz-Ramos D, Villatoro-Velázquez J, Bustos-Gamiño M, Medina-Mora M, Tovilla-Zárate C, Cruz-Castillo J, Nicolini H, Genis-Mendoza A. Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels. International Journal Of Molecular Sciences 2024, 25: 10154. PMID: 39337639, PMCID: PMC11432505, DOI: 10.3390/ijms251810154.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPhenome-wide association studyAssociation studiesGenetics of LADANon-European populationsGenome-wideGenetic risk factorsGENESIS packageSoutheastern MexicoPopulation implicationsPheWASFAIM2Risk genotypesAnti-glutamic acid decarboxylase autoantibodiesGlutamate decarboxylase autoantibodiesAutoimmune diabetesBody adiposity measuresMexican populationLatent autoimmune diabetesPLINKBody mass indexGenesAdiposity measuresChildhood obesityType 2 diabetesA phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
Jennings M, Martínez-Magaña J, Courchesne-Krak N, Cupertino R, Vilar-Ribó L, Bianchi S, Hatoum A, Atkinson E, Giusti-Rodriguez P, Montalvo-Ortiz J, Gelernter J, Artigas M, 23andMe I, Aslibekyan S, Auton A, Babalola E, Bell R, Bielenberg J, Bryc K, Bullis E, Coker D, Partida G, Dhamija D, Das S, Elson S, Eriksson N, Filshtein T, Fitch A, Fletez-Brant K, Fontanillas P, Freyman W, Granka J, Heilbron K, Hernandez A, Hicks B, Hinds D, Jewett E, Jiang Y, Kukar K, Kwong A, Lin K, Llamas B, Lowe M, McCreight J, McIntyre M, Micheletti S, Moreno M, Nandakumar P, Nguyen D, Noblin E, O'Connell J, Petrakovitz A, Poznik G, Reynoso A, Schumacher M, Shastri A, Shelton J, Shi J, Shringarpure S, Su Q, Tat S, Tchakouté C, Tran V, Tung J, Wang X, Wang W, Weldon C, Wilton P, Wong C, Elson S, Edenberg H, Fontanillas P, Palmer A, Sanchez-Roige S. A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. EBioMedicine 2024, 103: 105086. PMID: 38580523, PMCID: PMC11121167, DOI: 10.1016/j.ebiom.2024.105086.Peer-Reviewed Original ResearchConceptsMultiple domains of healthDomains of healthEffects of alcohol consumptionAlcohol consumptionHealth outcomesPhenome-wide association studyAlcohol-related behaviorsCardio-metabolic healthPotential causal effectMendelian randomisation studiesGenome-wide association studiesPhenome-wide associationMR analysisPheWAS associationsMultiple domainsHypothesis-free approachPreventive medicineDiverse cohortPheWASAssociation studiesHealthReproductive healthAlcohol behaviorConsequences of drinkingEuropean cohortNeuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
Andrade-Brito D, Núñez-Ríos D, Martínez-Magaña J, Nagamatsu S, Rompala G, Zillich L, Witt S, Clark S, Lattig M, Montalvo-Ortiz J, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Keane T, Krystal J, Labadorf A, Logue M, Marx B, Mash D, McKee A, Miller M, Montalvo-Ortiz J, Noller C, Schnurr P, Scott W, Stein T, Ursano R, Williamson D, Wolf E, Young K. Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. Frontiers In Genetics 2024, 15: 1345410. PMID: 38633406, PMCID: PMC11021708, DOI: 10.3389/fgene.2024.1345410.Peer-Reviewed Original ResearchAssociated with alcohol use disorderAlcohol use disorderOrbitofrontal cortexEpigenome-wide association studiesUse disorderStudy of alcohol use disorderHuman orbitofrontal cortexAlcohol-related traitsHuman brainPostmortem brain samplesHuman postmortem brain samplesEnrichment analysisDifferential CpG sitesPostmortem brain tissueGenome-wide levelOxidative bisulfite sequencingAssessed 5Functional enrichment analysisBrain tissueFalse discovery rateBisulfite sequencingAssociation studiesDifferential methylationIdentified genesDNA methylation
2021
Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results
Nolasco-Rosales GA, Martínez-Magaña JJ, Juárez-Rojop IE, González-Castro TB, Tovilla-Zarate CA, García AR, Sarmiento E, Ruiz-Ramos D, Genis-Mendoza AD, Nicolini H. Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results. Nutrients 2021, 13: 3210. PMID: 34579086, PMCID: PMC8470254, DOI: 10.3390/nu13093210.Peer-Reviewed Original Research
2019
Identification of gene ontology and pathways implicated in suicide behavior: Systematic review and enrichment analysis of GWAS studies
González‐Castro T, Tovilla‐Zárate C, Genis‐Mendoza A, Juárez‐Rojop I, Nicolini H, López‐Narváez M, Martínez‐Magaña J. Identification of gene ontology and pathways implicated in suicide behavior: Systematic review and enrichment analysis of GWAS studies. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 180: 320-329. PMID: 31045331, DOI: 10.1002/ajmg.b.32731.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesBiological process gene ontologyGene OntologyProtein localizationPositive regulationKEGG pathwaysEnrichment analysisGenomes (KEGG) biological pathwaysHeterotypic cell-cell adhesionCell-cell adhesionGlucose importKyoto EncyclopediaGO analysisCardiomyopathy pathwaysGWAS studiesBiological pathwaysAssociation studiesGenesGenetic contributorsMultiple large-scale studiesEndopeptidase activityInsulin stimulusPathwayRegulationMuscle cell contraction