1994
HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons.
Johnson DR, Pober JS. HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons. Molecular And Cellular Biology 1994, 14: 1322-1332. PMID: 8289810, PMCID: PMC358487, DOI: 10.1128/mcb.14.2.1322.Peer-Reviewed Original ResearchBase SequenceBinding SitesCloning, MolecularConsensus SequenceDNA PrimersDNA-Binding ProteinsDrug SynergismGene ExpressionGenes, MHC Class IHeLa CellsHLA-B7 AntigenHumansInterferon-betaInterferon-gammaLymphotoxin-alphaMolecular Sequence DataNF-kappa BNuclear ProteinsPolymerase Chain ReactionPromoter Regions, GeneticRecombinant ProteinsSequence DeletionSequence Homology, Nucleic AcidTransfection
1988
Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.
Pober JS. Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology. American Journal Of Pathology 1988, 133: 426-33. PMID: 2462353, PMCID: PMC1880803.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndothelium, VascularHumansImmunity, CellularInflammationInterferonsInterleukinsLymphotoxin-alphaTumor Necrosis Factor-alphaConceptsEndothelial cell activationCell activationMolecular biologic techniquesEndothelial cell functionClinical studiesMorphologic definitionVascular endotheliumBiologic techniquesPatient-based clinical researchClinical researchBiologic definitionVivo studiesHarmful sequencesCell functionDysfunctionInjuryActivationRecent studiesThree distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons.
Lapierre LA, Fiers W, Pober JS. Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons. Journal Of Experimental Medicine 1988, 167: 794-804. PMID: 2450953, PMCID: PMC2188900, DOI: 10.1084/jem.167.3.794.Peer-Reviewed Original ResearchConceptsIFN-alphaIL-6Endothelial cellsClass IAction of lymphotoxinMHC antigen expressionIFN-alpha/betaClass II antigensClass I expressionClass II inductionTumor necrosis factorCultured human endothelial cellsClass I MHCRecombinant preparationsHuman endothelial cellsCytokine administrationMHC antigensII antigensPatient populationRegulatory cytokinesNecrosis factorAntigen expressionGamma interferonIFN-gammaI MHC
1987
Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts.
Kurt-Jones EA, Fiers W, Pober JS. Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts. The Journal Of Immunology 1987, 139: 2317-24. PMID: 3116078, DOI: 10.4049/jimmunol.139.7.2317.Peer-Reviewed Original ResearchActivation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.
Pober JS, Lapierre LA, Stolpen AH, Brock TA, Springer TA, Fiers W, Bevilacqua MP, Mendrick DL, Gimbrone MA. Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. The Journal Of Immunology 1987, 138: 3319-24. PMID: 3494766, DOI: 10.4049/jimmunol.138.10.3319.Peer-Reviewed Original ResearchConceptsTumor necrosis factorAction of lymphotoxinCultured human endothelial cellsHuman endothelial cellsIL-1 speciesPhorbol ester pretreatmentNecrosis factorLeukocyte adhesionEndothelial cellsRecombinant human tumor necrosis factorSecretion of lymphotoxinExpression of HLAIL-1 betaIL-1 alphaInhibited inductionHuman tumor necrosis factorActivated T cellsPhorbol esterInflammatory leukocyte adhesionRecombinant human lymphotoxinInflammatory cellsT cellsIL-1Hr pretreatmentIFN-gammaEffects of Tumour Necrosis Factor and Related Cytokines on Vascular Endothelial Cells
Pober J. Effects of Tumour Necrosis Factor and Related Cytokines on Vascular Endothelial Cells. Novartis Foundation Symposia 1987, 131: 170-191. PMID: 3330009, DOI: 10.1002/9780470513521.ch12.Peer-Reviewed Original ResearchConceptsIL-1 betaHuman endothelial cellsIL-1 alphaRelated cytokinesVascular endothelial cellsEndothelial cellsNecrosis factorEndothelial leucocyte adhesion moleculeIntercellular adhesion molecule-1Tumor necrosis factorInterleukin-1 betaAdhesion molecule-1Endothelial cell activationInterleukin-1 alphaCultured human endothelial cellsPhorbol esterEffects of TNFRecombinant human TNFCytoplasmic calcium concentrationIL-1 speciesMechanism of actionHEC adhesivenessInflammatory leucocytesCell surface expressionProtein kinase C pathway