2024
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrug Delivery SystemsFemaleHumansMacrophagesMiceMice, Inbred C57BLNanoparticlesPolymersTissue DistributionConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-life
1995
Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules.
Bradley JR, Thiru S, Pober JS. Hydrogen peroxide-induced endothelial retraction is accompanied by a loss of the normal spatial organization of endothelial cell adhesion molecules. American Journal Of Pathology 1995, 147: 627-41. PMID: 7677177, PMCID: PMC1870992.Peer-Reviewed Original ResearchConceptsMembrane protein distributionFocal adhesion plaquesAdjacent cellsNormal spatial organizationNew protein synthesisEndothelial cellsSurface protein expressionBeta 3 integrinActin organizationDendrite-like processesCell peripheryEndothelial retractionCell adhesion moleculeHuman umbilical vein endothelial cellsAdhesion plaquesUmbilical vein endothelial cellsCellular metabolismActin filamentsProtein distributionProtein synthesisVein endothelial cellsNormal endothelial cell functionEndothelial cell functionApical capCell retraction
1991
Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon.
Redl H, Dinges HP, Buurman WA, van der Linden CJ, Pober JS, Cotran RS, Schlag G. Expression of endothelial leukocyte adhesion molecule-1 in septic but not traumatic/hypovolemic shock in the baboon. American Journal Of Pathology 1991, 139: 461-6. PMID: 1714243, PMCID: PMC1886066.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion MoleculesE-SelectinImmunohistochemistryMalePapioShockShock, SepticTissue DistributionWounds and InjuriesConceptsEndothelial leukocyte adhesion molecule-1Leukocyte adhesion molecule-1Hypovolemic shockSeptic shockAdhesion molecule-1Endothelial leukocyte adhesion molecule-1 expressionMolecule-1Adhesion molecule-1 expressionGranulocyte elastase levelsMolecule-1 expressionELAM-1 expressionTumor necrosis factorDe novo expressionEndothelial activationElastase levelsLive Escherichia coliNeutrophil activationNecrosis factorImmunohistochemical techniquesELAM-1ELAM expressionStrong stainingNovo expressionSmall veinsHigh levels